Increased cytokine release from peripheral blood cells after acute stroke

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 9, 1999, Pages 1004-1009

  Ferrarese, Carlo ^a,b   Mascarucci, Paolo ^d   Zoia, Chiara ^a   Cavarretta, Rosella ^a,c   Frigo, Maura ^a   Begni, Barbara ^a,b   Sarinella, Federica ^d   Frattola, Lodovico ^a,c   De Simoni, Maria Grazia ^d  

^a UNIVERSITY OF MILAN   (Italy)

^b SCIENTIFIC INSTITUTE   (Italy)

^c IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Blood cells; Brain ischemia; Cytokine; Serum

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; FIBRINOGEN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PHOSPHOLIPID ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BIOASSAY; BLOOD CELL; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; HUMAN TISSUE; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SERUM; STROKE;

EID: 0033502965     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199909000-00008     Document Type: Article

References (13)

1. Banks WA, Kastin AJ, Gutierrez EG (1994) Penetration of interleukin-6 across the blood-brain barrier. Neurosci Lett 179:53-56
2. Beamer NB, Coull BM, Clark WM, Hazel JS, Silberger JR (1995) Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann Neural 37:800-804
3. Beamer NB, Coull BM, Clark WM, Briley DP, Wynn M, Sexton G (1998) Persistent inflammatory response in stroke survivors. Neurology 50:1722-1728
4. Brott T, Adams Jr. HP, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V, Rorick M, Moomaw CJ, Walker M (1989) Measurements of acute cerebral infarction: a clinical examination scale. Stroke 20:7864-7870
5. Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, Holtsberg FW, Mattson MP (1996) Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nature Med 2:7788-7794
6. Buttini M, Sauter A, Boddeke HWGM (1994) Induction of interleukin1 β mRNA after focal cerebral ischaemia in the rat. Mol Brain Res 23:126-134
7. Chen J, Simon R (1997) Ischemie tolerance in the brain. Neurology 48:306-311
8. Clark WM (1997) Cytokines and reperfusion injury. Neurology 49(suppl 4):4S10-4S14
9. DeGraba T, Penix L, McCarron R, Kelly B, Dutka A, Hallenbeck J (1996): Profile of inflammation following acute ischemic stroke in humans. Cerebrovasc Dis 6(suppl 2): 10
10. De Simoni MG, Sironi M, De Luigi A, Manfridi A, Mantovani A, Ghezzi P (1990) Intracerebroventricular injection of interleukin-1 induces high circulating levels of interleukin-6. J Exp Med 171: 1773-1778
11. De Simoni MG, De Luigi A, Gemma L, Sironi M, Manfridi A, Ghezzi P (1993) Modulation of systemic interleukin-6 induction by central interleukin-1. Am J Physiol 265 (Regulatory Integrative Comp Physiol 34):R739-R742
12. De Simoni MG, Del Bo R, De Luigi A, Simard S, Forloni G (1995) Central endotoxin induces different patterns of interleukin (IL)-1b and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and periphery. Endocrinology 136:897-902
13. De Simoni MG (1997) Two-way communication pathways between the brain and the immune system. A review. Neurosci Res Commun 21:3163-3172