Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation

Psychopharmacology

Volumn 222, Issue 3, 2012, Pages 533-541

  Domschke, Katharina ^a,b   Klauke, Benedikt ^a,c   Winter, Bernward ^a   Gajewska, Agnes ^b   Herrmann, Martin J ^b   Warrings, Bodo ^b   Mühlberger, Andreas ^b   Wosnitza, Katherina ^a   Dlugos, Andrea ^a   Naunin, Swantje ^a   Nienhaus, Kathrin ^a   Fobker, Manfred ^a   Jacob, Christian ^b   Arolt, Volker ^a   Pauli, Paul ^b   Reif, Andreas ^b   Zwanzger, Peter ^a   Deckert, Jürgen ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c Christoph Dornier Klinik for Psychotherapy   (Germany)

Author keywords

Acoustic startle reflex; Adenosine 2A receptor; Caffeine; Emotion; NPS; NPSR

Indexed keywords

CAFFEINE; NEUROPEPTIDE S; PLACEBO;

ADULT; AFFECT; ARTICLE; AUDITORY STIMULATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EMOTION; FEMALE; GENE; GENE FUNCTION; GENETIC VARIABILITY; GENOTYPE; HABITUATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; NPS GENE; PRIORITY JOURNAL; RESPONSE TIME; STARTLE REFLEX; STIMULUS RESPONSE;

ADULT; AFFECT; CAFFEINE; FEMALE; GENOTYPE; HUMANS; MALE; NEUROPEPTIDES; RECEPTOR, ADENOSINE A2A; RECEPTORS, NEUROPEPTIDE; STARTLE REACTION;

EID: 84864423466     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2678-0     Document Type: Article

References (61)

1. Alsene K, Deckert J, San P, de Wit H (2003) Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology 28:1694-1702
2. Armbruster D, Mueller A, Strobel A, Kirschbaum C, Lesch KP, Brocke B (2010) Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults. Biol Psychol 83:214-221
3. Bernat E, Patrick CJ, Benning SD, Tellegen A (2006) Effects of picture content and intensity on affective physiological response. Psychophysiology 43:93-103
4. Blumenthal TD, Cuthbert BN, Filion DL, Hackley S, Lipp OV, van Boxtel A (2005) Committee report: Guidelines for human startle eyeblink electromyographic studies. Psychophysiology 42:1-15
5. Boeck CR, Martinello C, de Castro AA, Moretti M, Dos Santos CT, Guerrini R, Calo G, Gavioli EC (2010) Blockade of adenosine A2A receptor counteracts neuropeptide-S-induced hyperlocomotion in mice. Naunyn Schmied Arch Pharmacol 381:153-160
6. Butler RW, Braff DL, Rausch JL, Jenkins MA, Sprock J, Geyer MA (1990) Physiological evidence of exaggerated startle response in a subgroup of Vietnam veterans with combat-related PTSD. Am J Psychiatry 147:1308-1312
7. Charney DS, Heninger GR, Jatlow PI (1985) Increased anxiogenic effects of caffeine in panic disorders. Arch Gen Psychiatry 42:233-243
8. Childs E, Hohoff C, Deckert J, Xu K, Badner J, de Wit H (2008) Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology 33:2791-2800
9. Dannlowski U, Kugel H, Franke F, Stuhrmann A, Hohoff C, Zwanzger P, Lenzen T, Grotegerd D, Suslow T, Arolt V, Heindel W, Domschke K (2011) Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli. Neuropsychopharmacology 36:1879-1885
10. de la Mora MP, Gallegos-Cari A, Rizmendi-Garcia Y, Marcellino D, Fuxe K (2010) Role of dopamine receptor mechanisms in the amygdaloid modulation of fear and anxiety: Structural and functional analysis. Prog Neurobiol 90:198-216
11. Deckert J, Nothen MM, Franke P, Delmo C, Fritze J, Knapp M, Maier W, Beckmann H, Propping P (1998) Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease. Mol Psychiatry 3:81-85
12. Dillon DG, LaBar KS (2005) Startle modulation during conscious emotion regulation is arousal-dependent. Behav Neurosci 119:1118-1124
13. Domschke K, Reif A, Weber H, Richter J, Hohoff C, Ohrmann P, Pedersen A, Bauer J, Suslow T, Kugel H, Heindel W, Baumann C, Klauke B, Jacob C, Maier W, Fritze J, Bandelow B, Krakowitzky P, Rothermundt M, Erhardt A, Binder EB, Holsboer F, Gerlach AL, Kircher T, Lang T, Alpers GW, Ströhle A, Fehm L, Gloster AT, Wittchen HU, Arolt V, Pauli P, Hamm A, Deckert J (2011) Neuropeptide S receptor gene-converging evidence for a role in panic disorder. Mol Psychiatry 16:938-948
14. Domschke K, Gajewska A, Winter B, Herrmann MJ, Warrings B, Mühlberger A, Wosnitza K, Glotzbach E, Conzelmann A, Dlugos A, Fobker M, Jacob C, Arolt V, Reif A, Pauli P, Zwanzger P, Deckert J (2012) ADORA2A gene variation, caffeine, and emotional processing: A multi-level interaction on startle reflex. Neuropsychopharmacology 37:759-769
15. Donner J, Haapakoski R, Ezer S, Melen E, Pirkola S, Gratacos M, Zucchelli M, Anedda F, Johansson LE, Söderhäll C, Orsmark-Pietras C, Suvisaari J, Martín-Santos R, Torrens M, Silander K, Terwilliger JD, Wickman M, Pershagen G, Lönnqvist J, Peltonen L, Estivill X, D'Amato M, Kere J, Alenius H, Hovatta I (2010) Assessment of the neuropeptide S system in anxiety disorders. Biol Psychiatry 68:474-483
16. Duangdao DM, Clark SD, Okamura N, Reinscheid RK (2009) Behavioral phenotyping of neuropeptide S receptor knockout mice. Behav Brain Res 205:1-9
17. Fendt M, Imobersteg S, Burki H, McAllister KH, Sailer AW (2010) Intra-amygdala injections of neuropeptide S block fearpotentiated startle. Neurosci Lett 474:154-157
18. Fendt M, Buchi M, Burki H, Imobersteg S, Ricoux B, Suply T (2011) Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response. Behav Brain Res 217:1-9
19. Freitag CM, Agelopoulos K, Huy E, Rothermundt M, Krakowitzky P, Meyer J, Meyer J, Deckert J, von Gontard A, Hohoff C (2010) Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder. Eur Child Adolesc Psychiatry 19:67-74
20. Giakoumaki SG, Roussos P, Bitsios P (2008) Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism. Neuropsychopharmacology 33:3058-3068
21. Grillon C (2002) Startle reactivity and anxiety disorders: Aversive conditioning, context, and neurobiology. Biol Psychiatry 52:958-975
22. Grillon C (2008) Models and mechanisms of anxiety: Evidence from startle studies. Psychopharmacology 199:421-437
23. Grillon C, Baas J (2003) A review of the modulation of the startle reflex by affective states and its application in psychiatry. Clin Neurophysiol 114:1557-1579
24. Grillon C, Ameli R, Goddard A, Woods SW, Davis M (1994) Baseline and fear-potentiated startle in panic disorder patients. Biol Psychiatry 35:431-439
25. Grillon C, Morgan CA, Davis M, Southwick SM (1998) Effects of experimental context and explicit threat cues on acoustic startle in Vietnam veterans with posttraumatic stress disorder. Biol Psychiatry 44:1027-1036
26. Hamilton SP, Slager SL, de Leon AB, Heiman GA, Klein DF, Hodge SE, Weissman MM, Fyer AJ, Knowles JA (2004) Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder. Neuropsychopharmacology 29:558-565
27. Hamm AO, Cuthbert BN, Globisch J, Vaitl D (1997) Fear and the startle reflex: Blink modulation and autonomic response patterns in animal and mutilation fearful subjects. Psychophysiology 34:97-107
28. Hohoff C, Domschke K, Schwarte K, Spellmeyer G, Vogele C, Hetzel G, Deckert J, Gerlach AL (2009) Sympathetic activity relates to adenosine A(2A) receptor gene variation in blood-injury phobia. J Neural Transm 116:659-662
29. Hohoff C, Mullings EL, Heatherley SV, Freitag CM, Neumann LC, Domschke K, Krakowitzky P, Rothermundt M, Keck ME, Erhardt A, Unschuld PG, Jacob C, Fritze J, Bandelow B, Maier W, Holsboer F, Rogers PJ, Deckert J (2010) Adenosine A(2A) receptor gene: Evidence for association of risk variants with panic disorder and anxious personality. J Psychiatr Res 44:930-937
30. Huang ZL, Qu WM, Eguchi N, Chen JF, Schwarzschild MA, Fredholm BB, Urade Y, Hayaishi O (2005) Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci 8:858-859
31. Jüngling K, Seidenbecher T, Sosulina L, Lesting J, Sangha S, Clark SD, Okamura N, Duangdao DM, Xu YL, Reinscheid RK, Pape HC (2008) Neuropeptide S-mediated control of fear expression and extinction: Role of intercalated GABAergic neurons in the amygdala. Neuron 59(2):298-310.
32. Klauke B, Deckert J, Reif A, Pauli P, Zwanzger P, Baumann C, Arolt V, Glockner-Rist A, Domschke K (2011) Serotonin transporter gene and childhood trauma-a GxE effect on anxiety sensitivity. Depression Anxiety 28:1048-1057
33. Klauke B, Deckert J, Zwanzger P, Baumann C, Arolt V, Pauli P, Reif A, Domschke K (2012) Neuropeptide S receptor gene (NPSR) and life events: GxE effects on anxiety sensitivity and its subdimensions. World J Biol Psychiatry. doi:10.3109/15622975.2011.646302
34. Lage R, Dieguez C, Lopez M (2006) Caffeine treatment regulates neuropeptide S system expression in the rat brain. Neurosci Lett 410:47-51
35. Lang PJ, Bradley MM, Cuthbert BN (1990) Emotion, attention, and the startle reflex. Psychol Rev 97:377-395
36. Lang A, Bradley B, Cuthbert BN (2005) International Affective Picture System (IAPS): Sffective ratings of pictures and instruction manual. University of Florida, Gainesville
37. Leonard SK, Dwyer JM, Sukoff Rizzo SJ, Platt B, Logue SF, Neal SJ, Malberg JE, Beyer CE, Schechter LE, Rosenzweig-Lipson S, Ring RH (2008) Pharmacology of neuropeptide S in mice: Therapeutic relevance to anxiety disorders. Psychopharmacol Berl 197:601-611
38. Libkuman TM, Otani H, Kern R, Viger SG, Novak N (2007) Multidimensional normative ratings for the International Affective Picture System. Behav Res Methods 39:326-334
39. Melzig CA, Weike AI, Hamm AO, Thayer JF (2009) Individual differences in fear-potentiated startle as a function of resting heart rate variability: Implications for panic disorder. Int J Psychophysiol 71:109-117
40. Meyer-Lindenberg A, Weinberger DR (2006) Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci 7:818-827
41. Mühlberger A, Wieser MJ, Pauli P (2008) Darkness-enhanced startle responses in ecologically valid environments: A virtual tunnel driving experiment. Biol Psychol 77:47-52
42. Okamura N, Hashimoto K, Iyo M, Shimizu E, Dempfle A, Friedel S, Reinscheid RK (2007) Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/ hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 31:1444-1448
43. Okamura N, Garau C, Duangdao DM, Clark SD, Jüngling K, Pape HC, Reinscheid RK (2011) Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain. Neuropsychopharmacology 36:744-752
44. Pacheco R, Pescador BB, Mendonca BP, Ramos SF, Guerrini R, Calo G, de Andrade VM, Gavioli EC, Boeck CR (2011) Role of the ecto-nucleotidases in the cooperative effect of adenosine and neuropeptide-S on locomotor activity in mice. Pharmacol Biochem Behav 99:726-730
45. Pape HC, Jungling K, Seidenbecher T, Lesting J, Reinscheid RK (2010) Neuropeptide S: A transmitter system in the brain regulating fear and anxiety. Neuropharmacology 58:29-34
46. Pauli P, Diedrich O, Müller A (2002) Covariation bias in the affectmodulated startle paradigm. J Behav Ther Exp Psychiatry 33:191-202
47. Pauli P, Conzelmann A, Mucha RF, Weyers P, Baehne CG, Fallgatter AJ, Jacob CP, Lesch KP (2010) Affect-modulated startle reflex and dopamine D4 receptor gene variation. Psychophysiology 47:25-33
48. Raczka KA, Gartmann N, Mechias ML, Reif A, Büchel C, Deckert J, Kalisch R (2010) A neuropeptide S receptor variant associated with overinterpretation of fear reactions: A potential neurogenetic basis for catastrophizing. Mol Psychiatry 15:1067-1074
49. Raiteri L, Luccini E, Romei C, Salvadori S, Calò G (2009) Neuropeptide S selectively inhibits the release of 5-HT and noradrenaline from mouse frontal cortex nerve endings. Br J Pharmacol 157:474-481
50. Reinscheid RK, Xu YL (2005) Neuropeptide S as a novel arousal promoting peptide transmitter. FEBS J 272:5689-5693
51. Reinscheid RK, Xu YL, Okamura N, Zeng J, Chung S, Pai R, Wang Z, Civelli O (2005) Pharmacological characterization of human and murine neuropeptide S receptor variants. J Pharmacol Exp Ther 315:1338-1345
52. Rizzi A, Vergura R, Marzola G, Ruzza C, Guerrini R, Salvadori S, Regoli D, Calo G (2008) Neuropeptide S is a stimulatory anxiolytic agent: A behavioural study in mice. Br J Pharmacol 154:471-479
53. Rogers PJ, Hohoff C, Heatherley SV, Mullings EL, Maxfield PJ, Evershed RP, Deckert J, Nutt DJ (2010) Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption. Neuropsychopharmacology 35:1973-1983
54. Ruzza C, Rizzi A, Trapella C, Pela M, Camarda V, Ruggirei V, Filaferro M, Cifani C, Reinscheid RK, Vitale G, Ciccocioppo R, Salvadori S, Guerrini R, Calo G (2010) Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68. Peptides 31:915-925
55. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59:22-33
56. Vitale G, Filaferro M, Ruggirei V, Pennella S, Frigeri C, Rizzi A, Guerrini R, Calò G (2008) Anxiolytic-like effect of neuropeptide S in the rat defensive burying. Peptides 29:2286-2291
57. Wegener G, Finger BC, Elfving B, Keller K, Liebenberg N, Fischer CW, Singewald N, Slattery DA, Neumann ID, Mathé AA (2011) Neuropeptide S alters anxiety, but not depression-like behaviour in Flinders Sensitive Line rats: A genetic animal model of depression. Int J Neuropsychopharmacol 9:1-13
58. Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O (2004) Neuropeptide S: A neuropeptide promoting arousal and anxiolytic-like effects. Neuron 43:487-497
59. Yang A, Palmer AA, de Wit H (2010) Genetics of caffeine consumption and responses to caffeine. Psychopharmacology 211:245-257
60. Yoon KL, Zinbarg RE (2007) Threat is in the eye of the beholder: Social anxiety and the interpretation of ambiguous facial expressions. Behav Res Ther 45:839-847
61. Zhu H, Mingler MK, McBride ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Williams MT, Vorhees CV, Rothenberg ME (2010) Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1. Psychoneuroendocrinology 35:1119-1132