Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption

Neuropsychopharmacology

Volumn 35, Issue 9, 2010, Pages 1973-1983

  Rogers, Peter J ^a   Hohoff, Christa ^b   Heatherley, Susan V ^a   Mullings, Emma L ^a   Maxfield, Peter J ^a   Evershed, Richard P ^a   Deckert, Jürgen ^c   Nutt, David J ^d  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

adenosine; alertness; anxiety; caffeine; headache; polymorphism

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; CAFFEINE; CAFFEINE ANHYDROUS POWDER; PLACEBO; UNCLASSIFIED DRUG; CENTRAL STIMULANT AGENT; METHYLXANTHINE; XANTHINE DERIVATIVE;

ADULT; AGED; ALERTNESS; ANXIETY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG USE; FEMALE; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; HABITUATION; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RANDOMIZED CONTROLLED TRIAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRANQUILIZING ACTIVITY; AROUSAL; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETICS; METABOLISM; MIDDLE AGED; PSYCHOMOTOR PERFORMANCE; REACTION TIME; SALIVA; WITHDRAWAL SYNDROME; YOUNG ADULT;

ADULT; ANXIETY; AROUSAL; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; GENOTYPE; HEADACHE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PSYCHOMOTOR PERFORMANCE; REACTION TIME; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; SALIVA; SUBSTANCE WITHDRAWAL SYNDROME; XANTHINES; YOUNG ADULT;

EID: 77954763359     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2010.71     Document Type: Article

References (32)

1. Alsene K, Deckert J, Sand P, de Wit H (2003). Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology 28: 1694-1702.
2. Barrett JC, Fry B, Mailer J, Daly MJ (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
3. Childs E, de Wit H (2006). Subjective, behavioural, and physiological effects of acute caffeine in light, nondependent caffeine users. Psychopharmacology 185: 514-523.
4. Childs E, Hohoff C, Deckert J, Xu K, Badner J, de Wit H (2008). Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology 33: 2791-2800.
5. Cornelis MC, El-SohemyA, Campos H (2007). Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. Am J Clin Nutr 86: 240-244.
6. Couturier EGM, Laman DM, van Duijn MAJ, van Duijn H (1997). Influence of caffeine and caffeine withdrawal on headache and cerebral blood flow velocities. Cephalalgia 17: 188-190.
7. Cunha RA, Ferre S, Vaugeois JM, Chen JF (2008). Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders. Curr Pharm Des 14: 1512-1524.
8. Deckert J, Nothen MM, Franke P, Delmo C, Fritze J, Knapp M et al (1998). Systematic mutation screening and association study of the A1 and A2A adenosine receptor genes in panic disorder suggest a contribution of the A2A gene to the development of disease. Mol Psychiatry 3: 81-85.
9. Evans SM, Griffiths RR (1992). Caffeine tolerance and choice in humans. Psychopharmacology 108: 51-59.
10. Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartan EE (1999). Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51: 83-133.
11. Freitag CM, Agelopoulos K, Huy E, Rothermundt M, Krakowitzky P, Meyer J et al (2010). Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder. Eur Child Adolesc Psychiatry 19: 67-74.
12. Goldstein A, Kaizer S, Whitby O (1969). Psychotropic effects of caffeine in man. IV. Quantitative and qualitative differences associated with habituation to coffee. Clin Pharmacol Ther 10: 489-497.
13. Hartley R, Smith IJ, Cookman JR (1985). Improved high- performance liquid-chromatographic method for the simultaneous determination of caffeine and its n-demethylated metabolites in plasma using solid-phase extraction. J Chromatogr 342: 105-117.
14. Haskell CF, Kennedy DO, Wesnes KA, Scholey AB (2005). Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology 179: 813-825.
15. Heatherley SV, Mullings EL, Tidbury MA, Rogers PJ (2006a). Caffeine consumption among a sample of UK adults. Appetite 47: 266.
16. Howell DC (1997). Statistical Methods for Psychology. Duxbury Press: Belmont, CA.
17. James JE (2004). Critical review of dietary caffeine and blood pressure: a relationship that should be taken more seriously. Psychosom Med 66: 63-71.
18. James JE, Rogers PJ (2005). Effects of caffeine on performance and mood: withdrawal reversal is the most plausible explanation. Psychopharmacology 182: 1-8.
19. Johansson B, Halldner L, Dunwiddie TV, Masino SA, Poelchen W, Gimenez-Llort L et al (2001). Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adeno- sine Ai receptor. Proc Natl Acad Sci USA 98: 9407-9412.
20. Juliano LM, Grifftihs RR (2004). A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity and associated features. Psychopharmacology 126: 1-29.
21. Ledent C, Vaugeois JM, Schiffmann SN, Pedrazzini T, El Yacoubi M, Vanderhaeghen JJ et al (1997). Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388: 674-678.
22. Ribeiro JA, Sebastiao AM, de Mendoncja A (2003). Adenosine receptors in the nervous system: pathophysiological implications. Prog Neurobiol 68: 377-392.
23. Rogers PJ, Heatherley SV, Hayward RC, Seer HC, Hill J, Kane M (2005). Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction. Psychopharmacology 179: 742-752.
24. Rogers PJ, Martin J, Smith C, Heatherley SV, Smit HJ (2003). Absence of reinforcing, mood and psychomotor performance effects of caffeine in habitual non-consumers of caffeine. Psychopharmacology 167: 54-62.
25. Rogers PJ, Smith JE, Heatherley SV, Pleydell-Pearce CW (2008). Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together. Psychopharmacology 195: 569-577.
26. Schiffmann SN, Fisone G, Moresco R, Cunha RA, Ferree S (2007). Adenosine A2A receptors and basal ganglia physiology. Prog Neurobiol 83: 277-292.
27. Sigmon SC, Herning RI, Better W, Cadet JL, Griffiths RR (2009). Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects. Psychopharmacology 204: 573-585.
28. Stern KN, Chait LD, Johanson CE (1989). Reinforcing and subjective effects of caffeine in normal human subjects. Psychopharmacology 98: 81-88.
29. Thayer RE (1989). The Biopsychology of Mood and Arousal. Oxford University Press: New York.
30. van Calker D, Biber K (2005). The role of glial adenosine receptors in neural resilience and the neurobiology of mood disorders. Neurochem Res 30: 1205-1217.
31. Veyrieras J-B, Kudaravalli S, Kim SY, Dermitzakis ET, Gilad Y, Stephens M et al (2008). High-resolution mapping of expression- QTLs yields insight into human gene regulation. PLoS Genet 5: e1000214.
32. Yu L, Frith MC, Suzuki Y, Peterfreund RA, Gearan T, Sugano S et al (2004). Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses. Brain Res 1000: 156-173.