Poor lysosomal membrane integrity in proximal tubule cells of haptoglobin 2-2 genotype mice with diabetes mellitus

Free Radical Biology and Medicine

Volumn 53, Issue 4, 2012, Pages 779-786

  Asleh, Rabea ^a   Nakhoul, Farid M ^a,b   Miller Lotan, Rachel ^a   Awad, Hoda ^a   Farbstein, Dan ^a   Levy, Nina S ^a   Nakhoul, Nakhoul ^b   Iancu, Theodore C ^a   Manov, Irena ^a   Laue, Michael ^c   Traber, Maret G ^d   Lebold, Katie M ^d   Levy, Andrew P ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b BAR ILAN UNIVERSITY   (Israel)

^c ROBERT KOCH INSTITUTE   (Germany)

^d OREGON STATE UNIVERSITY   (United States)

Author keywords

Diabetes; Haptoglobin genotype; Iron induced injury; Lysosome; Nephropathy; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; HAPTOGLOBIN; IRON; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; DISEASE COURSE; ELECTRON ENERGY LOSS SPECTROSCOPY; FINITE ELEMENT ANALYSIS; GENOTYPE; IRON OVERLOAD; KIDNEY INJURY; KIDNEY TUBULE CELL; KIDNEY TUBULE DAMAGE; LIPID PEROXIDATION; LYSOSOME; MEMBRANE STRUCTURE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; ROENTGEN SPECTROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTIOXIDANTS; BETA-N-ACETYLHEXOSAMINIDASES; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; GENOTYPE; HAPTOGLOBINS; INTRACELLULAR MEMBRANES; IRON; KIDNEY TUBULES, PROXIMAL; LIPID PEROXIDATION; LYSOSOMES; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; OXIDATIVE STRESS; VITAMIN E;

MUS;

EID: 84864416943     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.06.015     Document Type: Article

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