Occurrence and reduction of pharmaceuticals in thewater phase at Swedish wastewater treatment plants

Water Science and Technology

Volumn 66, Issue 4, 2012, Pages 783-791

  Falas P ^a   Andersen, H R ^b   Ledin, A ^a   La Cour Jansen, J ^a  

^a LUND UNIVERSITY   (Sweden)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Biological treatment; Pharmaceuticals; Wastewater treatment

Indexed keywords

ACTIVATED SLUDGE PLANTS; BIOLOGICAL TREATMENT; EFFLUENT CONCENTRATIONS; PARENT COMPOUNDS; REDUCTION DEGREE; RESEARCH INSTITUTES; SALE VOLUMES; SCREENING PROGRAMS; TRICKLING FILTER; WASTEWATER TREATMENT PLANTS;

BIOCHEMICAL ENGINEERING; DRUG PRODUCTS; EFFLUENTS; SEWAGE PUMPING PLANTS; WASTEWATER TREATMENT; WATER TREATMENT PLANTS;

ANTIBIOTICS;

ATENOLOL; CHEMICALS AND DRUGS; FUROSEMIDE; HYDROCHLOROTHIAZIDE; IBUPROFEN; KETOPROFEN; METOPROLOL; NAPROXEN; NITROGEN; NON ANTIBIOTIC PHARMACEUTICAL; UNCLASSIFIED DRUG;

ACTIVATED SLUDGE; ANTIBIOTICS; CONCENTRATION (COMPOSITION); DRUG; EFFLUENT; FILTER; FRACTIONATION; NITROGEN; WASTEWATER; WATER TREATMENT;

ACTIVATED SLUDGE; ARTICLE; ENVIRONMENTAL MANAGEMENT; ENVIRONMENTAL MONITORING; SWEDEN; WASTE COMPONENT REMOVAL; WASTE WATER MANAGEMENT; WATER POLLUTANT;

BACTERIA; BIOREACTORS; COMMERCE; ENVIRONMENTAL MONITORING; FILTRATION; PHARMACEUTICAL PREPARATIONS; SWEDEN; WASTE DISPOSAL, FLUID; WATER POLLUTANTS, CHEMICAL;

SWEDEN;

EID: 84864411426     PISSN: 02731223     EISSN: None     Source Type: Journal    
DOI: 10.2166/wst.2012.243     Document Type: Article

References (35)

1. Andersson, J., Woldegiorgis, A., Remberger, M., Kaj, L., Ekheden, Y., Dusan, B., Svenson, A., Brorström-Lundén, E., Dye, C. & Schlabach, M. 2006 Results from the Swedish National Screening Program 2005: Sub report 1: Antibiotics, Antiinflammatory substances, and Hormones, Report: B1689, IVL (Swedish Environmental Research Institute). Available from: http://www.ivl.se/download/18.7df4c4e812d2da6a416800071887/B1689.pdf (accessed 17 December 2011).
2. Bendz, D., Paxéus, N. A., Ginn, T. R. & Loge, F. J. 2005 Occurrence and fate of pharmaceutically active compounds in the environment, a case study: Höje river in Sweden. Journal of Hazardous Materials 122 (3), 195-204.
3. Buntner, D., Źabczyński, S. & Miksch, K. 2007 Report of the limitations of conventional treatment processes of the most resistant PPs and new development, Deliverable 2.1. Available from: http://www.knappe-eu.org/ fichiers/45-Knappe%20D2. 1%20Report%20of%20the%20limitations%20of%20conventional%20treatment%20processes. ...pdf (accessed 19 December 2011).
4. Carballa, M., Omil, F., Lema, J. M., Llompart, M., García-Jares, C., Rodriguez, I., Gómez, M. & Ternes, T. 2004 Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant. Water Research 38 (12), 2918-2926.
5. Clara, M., Strenn, B., Gans, O., Martinez, E., Kreuzinger, N. & Kroiss, H. 2005a Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants. Water Research 39 (19), 4797-4807.
6. Clara, M., Kreuzinger, N., Strenn, B., Gans, O. & Kroiss, H. 2005b The solids retention time - a suitable design parameter to evaluate the capacity of wastewater treatment plants to remove micropollutants. Water Research 39 (1), 97-106.
7. Falås, P., Andersen, H. R., Ledin, A. & la Cour Jansen, J. (in press). Impact of solid retention time and nitrification capacity on the ability of activated sludge to remove pharmaceuticals. Environmental Technology (Available from: http://www.tandfonline.com/doi/abs/10.1080/09593330.2011. 601764).
8. Favetta, P., Degoute, C.-S., Perdrix, J.-P., Dufresne, C., Boulieu, R. & Guitton, J. 2002 Propofol metabolites in man following propofol induction and maintenance. British Journal of Anaesthesia 88 (5), 653-658.
9. Helmfrid, I. 2006 Läkemedel i miljön: Läkemedelsflö den i Östergötlands och Jönköpings län samt stora sjöarna Vättern, Vänern och Mälaren (Pharmaceuticals in Environment: Pharmaceutical flows in Östergötland and Jönköping County Councils, and the large lakes Vättern, Vänern, and Mälaren), Report: 2006:1, Östergötland County Council.
10. Helmfrid, I. & Eriksson, C. 2010 Läkemedelsrester från sjukhus och avloppsreningsverk (Pharmaceutical residues from hospitals and wastewater treatment plants), Report: 2010:1, Östergötland County Council.
11. Hörsing, M., Ledin, A., Grabic, R., Fick, J., Tysklind, M., la Cour Jansen, J. & Andersen, H. R. 2011 Determination of sorption of seventy-five pharmaceuticals in sewage sludge. Water Research 45 (15), 4470-4482.
12. Joss, A., Zabczynski, S., Göbel, A., Hoffmann, B., Löffler, D., McArdell, C. S., Ternes, T. A., Thomsen, A. & Siegrist, H. 2006 Biological degradation of pharmaceuticals in municipal wastewater treatment: proposing a classification scheme. Water Research 40 (8), 1686-1696.
13. Kahn, S. J. & Ongerth, J. E. 2004 Modelling of pharmaceutical residues in Australian sewage by quantities of use and fugacity calculations. Chemosphere 54 (3), 355-367.
14. Kasprzyk-Hordern, B., Dinsdale, R. M. & Guwy, A. J. 2009 The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters. Water Research 43 (2), 363-380.
15. Kimura, K., Hara, H. & Watanabe, Y. 2007 Elimination of selected acidic pharmaceuticals from municipal wastewater by an activated sludge system and membrane bioreactors. Environmental Science and Technology 41 (10), 3708-3714.
16. Kirk, L. A., Tyler, C. R., Lye, C. M. & Sumpter, J. P. 2002 Changes in estrogenic and androgenic activities at different stages of treatment in wastewater treatment works. Environmental Toxicology and Chemistry 21 (5), 972-979.
17. Landstinget Sörmland (Sörmland county council) 2010 Personal communication with Krumlinde Catharina.
18. Landstinget & Uppsala län (Uppsala County Council). Kartläggning av läkemedelsrester i avlopps- och dricksvatten vid Akademiska sjukhuset, Uppsala och Lasarettet i Enköping hösten 2005 (Mapping of pharmaceutical residues in wastewater and drinking water at the Academic hospital, Uppsala, and Enköping Hospital - fall 2005). Available from: http://www.lul.se/upload/miljo/Rapport%20provtagningsresultat.pdf (accessed 17 December 2011).
19. LIF (The research-based pharmaceutical industry in Sweden). FASS. Available from: http://www.fass.se/LIF/home/index. jsp (accessed 17 December 2011).
20. Luan, L.-J., Shao, Q., Ma, J.-Y. & Zeng, S. 2005 Stereoselective urinary excretion of S-(-)- and R-(+)-propranolol glucuronide following oral administration of RS-propranolol in chinese han subjects. World Journal of Gastroenterology 11 (12), 1822-1824.
21. Miège, C., Choubert, J. M., Ribeiro, L., Eusèbe, M. & Coquery, M. 2009 Fate of pharmaceuticals and personal care products in wastewater treatment plants - conception of a database and first results. Environmental Pollution 157 (5), 1721-1726.
22. Maggs, J. L., Pirmohamed, M., Kitteringham, N. R. & Park, B. K. 1997 Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography/mass spectrometry. Drug Metabolism and Disposition 25 (3), 275-280.
23. Paxéus, N. 2004 Removal of selected non-steroidal antiinflammatory drugs (NSAIDs), gemfibrozil, carbamazepine, β-blockers, trimethoprim and triclosan in conventional wastewater treatment plants in five EU countries and their discharge to the aquatic environment. Water Science and Technology 50 (5), 253-260.
24. Paxéus, N. 2010 Analys av läkemedelsrester i dricks- och avloppsvatten: En provningsjämförelese (Analysis of pharmaceutical residues in drinking water and wastewater: A sample comparison), Report: 10SV74, Stockholm Water. Available from: http://www.stockholmvatten.se/commondata/ rapporter/avlopp/Processer/SVAB%20Interkalibrering%20.pdf (accessed 17 December 2011).
25. Region Skåne (Skåne County Council) 2006 Lä kemedelsrester: Universitetssjukhuset MAS i Malmö (Pharmaceutical residues: Malmö University Hospital in Malmö). Available from: http://www.miljo.skane.se/sv/d/bilagor/ Slutrapport%20L%E4kemedelsprojekt%20UMAS%202004%20-%202006.pdf (accessed 17 December 2011).
26. Statistics Sweden 2010 Utsläpp till vatten och slamproduktion 2008: Kommunala reningsverk, skogsindustri samt viss övrig industri (Discharges to water and sewage sludge production in 2008: Municipal waste water treatment plants, pulp and paper industry and other industry), Report: MI 22 SM 1001.
27. Svenson, A., Allard, A. & Ek, M. 2003 Removal of estrogenicity in Swedish municipal sewage treatment plants. Water Research 37 (18), 4433-4443.
28. Swedish EPA 1994 Statens Naturvårdsverks Författningssamling (Swedish EPA statue book). SNFS, 1994:7, ISSN 0347-5301.
29. Stockholms läns landsting (StockholmCounty Council, Stockholm, Sweden). Available from: www.sll.se/upload/Miljö/Lakemrest-akv-miljo.xls. (accessed 17 December 2011).
30. Strenn, B., Clara, M., Gans, O. & Kreuzinger, N. 2004 Carbamazepine, diclofenac, ibuprofen and bezafibrate - investigations on the behaviour of selected pharmaceuticals during wastewater treatment. Water Science and Technology 50 (5), 269-276.
31. Ternes, T. & Joss, A. (eds) 2006 Human Pharmaceuticals, Hormones and Fragrances: The Challenge of Micropollutants in Urban Water Management. IWA Publishing, London.
32. Västra Götalandsregionen (Region Västra Götaland) 2008 Läkemedels miljöpåverkan: Rapport - kartläggning av läkemedelsrester i Västra Götaland (Impact of pharmaceuticals on environment: Report - mapping of pharmaceutical residues in Västra Götaland). Available from: http://www.filmivast.se/upload/L%C3%A4kemedel/ L%C3%A4kemedel%20i%20regionen/Rapport%20- %20Kartl%C3%A4ggning% 20av%20l%C3%A4kemedelsrester%20i%20V%C3% A4stra%20G%C3%B6taland.pdf (accessed 17 December 2011).
33. Woldegiorgis, A., Green, J., Remberger, M., Kaj, L., Brorström- Lundén, E., Dye, C. & Schlabach, M. 2007 Results from the Swedish screening 2006: Sub report 4: Pharmaceuticals, Report: B1751, IVL (Swedish Environmental Research Institute). Available from: http://www.ivl.se/download/ 18.7df4c4e812d2da6a416800071947/B1751.pdf (accessed 17 December 2011).
34. Zorita, S., Mårtensson, L. & Mathiasson, L. 2009 Occurrence and removal of pharmaceuticals in a municipal sewage treatment system in the south of Sweden. Science of the Total Environment 407 (8), 2760-2770.
35. Zuccato, E., Castiglioni, S. & Fanelli, R. 2005 Identification of the pharmaceuticals for human use contaminating the Italian aquatic environment. Journal of Hazardous Materials 122 (3), 205-209.