A Randomized controlled trial of empiric warfarin dose reduction with the initiation of doxycycline therapy

Thrombosis Research

Volumn 130, Issue 2, 2012, Pages 152-156

  Dowd, Mary Beth ^a   Kippes, Kellie A ^a   Witt, Daniel M ^a   Delate, Thomas ^a   Martinez, Kerri ^a  

^a Exempla Saint Joseph Hospital   (United States)

Author keywords

doxycycline; Drug interactions; pharmacists; warfarin

Indexed keywords

DOXYCYCLINE; VITAMIN K GROUP; WARFARIN;

ADULT; AGED; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG MONITORING; DRUG SAFETY; EPISTAXIS; FEMALE; FOLLOW UP; HUMAN; INTERNATIONAL NORMALIZED RATIO; LOWER LEG; MALE; PRESCRIPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN BRUISING; TREATMENT DURATION; TREATMENT OUTCOME;

AGED; ANTI-BACTERIAL AGENTS; ANTICOAGULANTS; DOXYCYCLINE; DRUG DOSAGE CALCULATIONS; DRUG INTERACTIONS; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERNATIONAL NORMALIZED RATIO; MALE; MIDDLE AGED; WARFARIN;

EID: 84864404535     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.12.017     Document Type: Article

References (15)

1. T. Baglin Avoiding overanticoagulation: knowing your antibiotics Thromb Haemost 88 2002 703 704 (Pubitemid 35345322)
2. L.K. Westfall, D.L. Mintzer, and T.H. Wiser Potentiation of warfarin by tetracycline Am J Hosp Pharm 37 1980 1620 1625
3. Y. Caraco, and A. Rubinow Enhanced anticoagulant effect of coumarin derivatives induced by doxycycline coadministration Ann Pharmacother 26 1992 1084 1086
4. A.M. Baciewicz, and B.S. Bal Bleeding associated with doxycycline and warfarin treatment Arch Intern Med 161 2001 1231 (Pubitemid 32691520)
5. S.A. Hasan Interaction of doxycycline and warfarin: an enhanced anticoagulant effect Cornea 26 2007 742 743 (Pubitemid 47080297)
6. H.F. Chambers Chloramphenicol, tetracyclines, macrolides, clindamycin, and streptogramins B.G. Katzung, Basic and Clinical Pharmacology 2001 McGraw-Hill New York 774 783 Basic and Clinical Pharmacology. New York: McGraw-Hill; 2001:774-783
7. J. Ansell, J. Hirsh, E. Hylek, A. Jacobson, M. Crowther, and G. Palareti Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest 133 2008 160S 198S (Pubitemid 351892967)
8. J. Hirsh, V. Fuster, J. Ansell, and J.L. Halperin American Heart Association/American College of Cardiology Foundation guide to warfarin therapy J Am Coll Cardiol 41 2003 1633 1652 (Pubitemid 36543387)
9. G.A. Banet, A.D. Waterman, P.E. Milligan, S.K. Gatchel, and B.F. Gage Warfarin dose reduction vs watchful waiting for mild elevations in the international normalized ratio Chest 123 2003 499 503 (Pubitemid 36269436)
10. M.A. Raebel, D.M. Witt, N.M. Carroll, and D.J. Magid Warfarin Monitoring in Ambulatory Older Individuals Receiving Antimicrobial Therapy Pharmacotherapy 25 8 2005 1055 1061 (Pubitemid 41099439)
11. A. Ahmed, J.C. Stephens, C.A. Kaus, and W.P. Fay Impact of preemptive warfarin dose reduction on anticoagulation after initiation of trimethoprim-sulfamethoxazole or levofloxacin J Thromb Thrombolysis 26 2008 44 48
12. M.B. Dowd, K.A. Vavra, D.M. Witt, T. Delate, and K. Martinez Empiric warfarin dose adjustment with prednisone therapy. A randomized, controlled trial J Thromb Thrombolysis 31 2011 472 477
13. D.M. Witt, M.A. Sadler, R.L. Shanahan, G. Mazzoli, and D.J. Tillman Effect of a centralized clinical pharmacy anticoagulation service on the outcomes of anticoagulation therapy Chest 127 2005 1515 1522 (Pubitemid 46218774)
14. M.A. Crowther, W. Ageno, D. Garcia, L. Wang, D.M. Witt, and N.P. Clark Oral Vitamin K Versus Placebo to Correct Excessive Anticoagulation in Patients Receiving Warfarin Ann Intern Med 150 2009 293 300
15. N.P. Clark, D.M. Witt, T. Delate, M. Trapp, D. Garcia, and W. Ageno Thromboembolic Consequences of Subtherapeutic Anticoagulation in Patients Stabilized on Warfarin Therapy: The Low INR Study Pharmacotherapy 28 2008 960 967