Plasminogen activator inhibitor-1 (PAI-1) 4 G/5 G polymorphism and endometrial cancer. Influence of PAI-1 polymorphism on tissue PAI-1 antigen and mRNA expression and tumor severity

Thrombosis Research

Volumn 130, Issue 2, 2012, Pages 242-247

  Gilabert Estellés, Juan ^a   Ramón, Luis A ^b   Braza Boïls, Aitana ^b   Gilabert, Juan ^c   Chirivella, Melitina ^b   España, Francisco ^b   Estellés, Amparo ^b  

^a HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c HOSPITAL ARNAU DE VILANOVA   (Spain)

Author keywords

Endometrial cancer; fibrinolysis; PAI 1 4G 5G polymorphism (rs1799889); plasminogen activator inhibitor 1 (PAI 1); SERPINE1

Indexed keywords

GLYCINE; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE EXTRACT;

ADULT; AGED; ALLELE; ARTICLE; CANCER STAGING; CONTROLLED STUDY; DISEASE SEVERITY; ENDOMETRIUM CANCER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE FREQUENCY; GENOTYPE; HUMANS; MIDDLE AGED; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER;

EID: 84864401815     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.10.007     Document Type: Article

References (46)

1. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics, 2010 CA Cancer J Clin 60 2010 277 300
2. P.A. Andreasen, L. Kjoller, L. Christensen, and M.J. Duffy The urokinase-type plasminogen activator system in cancer metastasis: a review Int J Cancer 72 1997 1 22 (Pubitemid 27314632)
3. D. Loskutoff Regulation of PAI-1 gene expression Fibrinolysis 5 1991 197 206
4. P.A. Andreasen, B. Georg, L.R. Lund, A. Riccio, and S.N. Stacey Plasminogen activator inhibitors: hormonally regulated serpins Mol Cell Endocrinol 68 1990 1 19 (Pubitemid 20015463)
5. A. Estellés, J. Gilabert, M. Keeton, Y. Eguchi, J. Aznar, and S. Grancha Altered expression of plasminogen activator inhibitor type 1 in placentas from pregnant women with preeclampsia and/or intrauterine fetal growth retardation Blood 84 1994 143 150 (Pubitemid 24193815)
6. I.M. Lang, K.M. Moser, and R.R. Schleef Elevated expression of urokinase-like plasminogen activator and plasminogen activator inhibitor type 1 during the vascular remodeling associated with pulmonary thromboembolism Arterioscler Thromb Vasc Biol 18 1998 808 815 (Pubitemid 28267662)
7. R. Castelló, A. Estellés, C. Vázquez, C. Falcó, F. España, and S.M. Almenar Quantitative real-time reverse transcription-PCR assay for urokinase plasminogen activator, plasminogen activator Inhibitor type 1 (PAI-1) and tissue metalloproteinase inhibitor type 1 (TIMP-1) gene expression in primary breast cancer Clin Chem 48 2002 1288 1295 (Pubitemid 34809838)
8. S.A. Rabbani, and A.P. Mazar The role of the plasminogen activation system in angiogenesis and metastasis Surg Oncol Clin N Am 10 2001 393 415 (Pubitemid 32472537)
9. N. Harbeck, A. Kruger, S. Sinz, R.E. Kates, C. Thomssen, and M. Schmitt Clinical relevance of the plasminogen activator inhibitor type 1, a multifaceted proteolytic factor Onkologie 24 2001 238 244 (Pubitemid 32664553)
10. D.J. Loskutoff, J.A. van Mourik, L.A. Erickson, and D. Lawrence Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells Proc Natl Acad Sci U S A 80 1983 2956 2960 (Pubitemid 13104156)
11. E. Steiner, K. Pollow, D. Hasenclever, W. Schormann, M. Hermes, and M. Schmidt Role of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) for prognosis in endometrial cancer Gynecol Oncol 108 2008 569 576
12. M. Fredstorp-Lidebring, P.O. Bendahl, N. Brünner, B. Casslén, T. Högberg, and E. Långström-Einarsson Urokinase plasminogen activator and its inhibitor, PAI-1, in association with progression-free survival in early stage endometrial cancer Eur J Cancer 37 2001 2339 2348 (Pubitemid 33097469)
13. C. Tecimer, D.L. Doering, L.J. Goldsmith, J.S. Meyer, G. Abdulhay, and J.L. Wittliff Clinical relevance of urokinase-type plasminogen activator, its receptor, and its inhibitor type 1 in endometrial cancer Gynecol Oncol 80 2001 48 55 (Pubitemid 32062088)
14. J.A. Foekens, H.A. Peters, M.P. Look, H. Portengen, M. Schmitt, and M.D. Kramer The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients Cancer Res 60 2000 636 643 (Pubitemid 30094561)
15. K. Sumiyoshi, S. Baba, S. Sakaguchi, T. Urano, Y. Takada, and A. Takada Increase in levels of plasminogen activator and type-1 plasminogen activator inhibitor in human breast cancer: possible roles in tumor progression and metastasis Thromb Res 63 1991 59 71
16. R. Castello, A. Estelles, C. Vazquez, C. Falco, F. España, and S.M. Almenar Quantitative real-time reverse transcription-PCR assay for urokinase plasminogen activator, plasminogen activator inhibitor type 1, and tissue metalloproteinase inhibitor type 1 gene expressions in primary breast cancer Clin Chem 48 2002 1288 1295 (Pubitemid 34809838)
17. R.P. Czekay, K. Aertgeerts, S.A. Curriden, and D.J. Loskutoff Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins J Cell Biol 160 2003 781 791 (Pubitemid 36298272)
18. D.J. Loskutoff, S.A. Curriden, G. Hu, and G. Deng Regulation of cell adhesion by PAI-1 APMIS 107 1999 54 61 (Pubitemid 29133523)
19. K. Bajou, A. Noel, R.D. Gerard, V. Masson, N. Brunner, and C. Holst-Hansen Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization Nat Med 4 1998 923 928 (Pubitemid 28364031)
20. K. Bajou, V. Masson, R.D. Gerard, P.M. Schmitt, V. Albert, and M. Praus The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies J Cell Biol 152 2001 777 784 (Pubitemid 34280162)
21. C. Roca, L. Primo, D. Valdembri, A. Cividalli, P. Declerck, and P. Carmeliet Hyperthermia inhibits angiogenesis by a plasminogen activator inhibitor 1-dependent mechanism Cancer Res 63 2003 1500 1507 (Pubitemid 36373635)
22. D.J. Webb, K.S. Thomas, and S.L. Gonias Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth J Cell Biol 152 2001 741 752
23. F. Taponeco, C. Curcio, and A. Giuntini Expresion and prognostic significance of urokinase and plasminogen activator inhibitor type-1 in endometrial hyperplasia and cancer J Exp Clin Cancer Res 20 2001 239 246 (Pubitemid 32641067)
24. M.C. Alessi, I. Juhan-Vague, T. Kooistra, P.J. Declerck, and D. Collen Insulin stimulates the synthesis of plasminogen activator inhibitor 1 by the human hepatocellular cell line Hep G2 Thromb Haemost 60 1988 491 494 (Pubitemid 19023748)
25. D.J. Loskutoff, M. Sawdey, M. Keeton, and J. Schneiderman Regulation of PAI-1 gene expression in vivo Thromb Haemost 70 1993 135 137 (Pubitemid 23225465)
26. M. Henry, N. Chomiki, P.Y. Scarabin, M.C. Alessi, F. Peiretti, and D. Arveiler Five frequent polymorphisms of the PAI-1 gene: lack of association between genotypes, PAI activity, and triglyceride levels in a healthy population Arterioscler Thromb Vasc Biol 17 1997 851 858 (Pubitemid 27209261)
27. P. Eriksson, B. Kallin, F.M. van 't Hooft, P. Bavenholm, and A. Hamsten Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction Proc Natl Acad Sci U S A 92 1995 1851 1855
28. C. Roncal, J. Orbe, J.A. Rodriguez, M. Belzunce, O. Beloqui, J. Diez, and J.A. Páramo Influence of the 4G/5G PAI-1 genotype on angiotensin II-stimulated human endothelial cells and in patients with hypertension Cardiovasc Res 63 2004 176 185 (Pubitemid 38759823)
29. S.J. Dawson, B. Wiman, A. Hamsten, F. Green, S. Humphries, and A.M. Henney The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells J Biol Chem 268 1993 10739 10745 (Pubitemid 23162248)
30. S. Grancha, A. Estellés, G. Tormo, C. Falcó, J. Gilabert, and F. España Plasminogen activator inhibitor-1 (PAI-1) promoter 4G/5G genotype and increased PAI-1 circulating levels in postmenopausal women with coronary artery disease Thromb Haemost 81 1999 516 521 (Pubitemid 29178933)
31. E. Solá, A. Vayá, F. España, R. Castelló, L.A. Ramón, and A. Hernández-Mijares Plasminogen activator inhibitor-1 levels in severe and morbid obesity. Effect of weight loss and influence of 4G/5G polymorphism Thromb Res 122 2008 320 327 (Pubitemid 351888888)
32. A.E. Tsantes, G.K. Nikolopoulos, P.G. Bagos, S. Bonovas, P. Kopterides, and G. Vaiopoulos The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk Thromb Res 122 2008 736 742
33. R. Castelló, F. España, C. Vázquez, C. Fuster, S.M. Almenar, J. Aznar, and A. Estellés Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in human breast cancer and its association with tissue PAI-1 levels and severity tumor grade Thromb Res 117 2006 487 492 (Pubitemid 43326132)
34. J. Błasiak, and B. Smolarz Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G promoter polymorphism is not associated with breast cancer Acta Biochim Pol 47 2000 191 199
35. H. Ju, B. Lim, M. Kim, S.M. Noh, W.H. Kim, C. Ihm, B.Y. Choi, Y.S. Kim, and C. Kang SERPINE1 intron polymorphisms affecting gene expression are associated with diffuse-type gastric cancer susceptibility Cancer 116 2010 4248 4255
36. H. Lei, K. Hemminki, R. Johansson, A. Altieri, K. Enquist, R. Henriksson, P. Lenner, and A. Försti PAI-1-675 4G/5G polymorphism as a prognostic biomarker in breast cancer Breast Cancer Res Treat 109 2008 165 175 (Pubitemid 351538765)
37. C.J. Weng, C.M. Tsai, Y.C. Chen, Y.H. Hsieh, C.W. Lin, Y.F. Liu, S.C. Su, M.K. Chen, and S.F. Yang Evaluation of the association of urokinase plasminogen activator system gene polymorphisms with susceptibility and pathological development of hepatocellular carcinoma Ann Surg Oncol 17 2010 3394 3401
38. FIGO Committee on Gynecologyc Oncology Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium Int J Gynecol Obstet 105 2009 103 104
39. R.J. Kurman, R.J. Zaino, and H.J. Norris Endometrial Carcinoma R.J. Kurman, Blaustein's Pathology of the Female Genital Tract 1994 Springer New York 439 486
40. J. Gilabert-Estellés, A. Estellés, J. Gilabert, R. Castelló, F. España, C. Falcó, A. Romeu, M. Chirivella, E. Zorio, and J. Aznar Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis Hum Reprod 18 2003 1516 1522 (Pubitemid 36840963)
41. J. Gilabert-Estellés, L.A. Ramón, F. España, J. Gilabert, V. Vila, E. Réganon, R. Castelló, M. Chirivella, and A. Estellés Expression of angiogenic factors in endometriosis: its relation to fibrinolytic and metalloproteinase (MMP) systems Hum Reprod 22 2007 2120 2127 (Pubitemid 47241856)
42. L. Ramón, J. Gilabert-Estellés, R. Castelló, J. Gilabert, F. España, A. Romeu, M. Chirivella, J. Aznar, and A. Estellés mRNA quantitative analysis of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis using real-time reverse transcription-PCR assay Hum Reprod 20 2005 272 278
43. L.A. Ramón, J. Gilabert-Estellés, R. Cosín, J. Gilabert, F. España, R. Castelló, M. Chirivella, A. Romeu, and A. Estellés Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism and endometriosis. Influence of PAI-1 polymorphism on PAI-1 antigen and mRNA expression Thromb Res 122 2008 854 860
44. J.J. Parrilla, J. Aznar, and A. Estelles Fibrinolytic activity in the endometrial adenocarcinoma Thromb Diath Haemorrh 34 1975 864 866
45. U. Köhler, K. Hiller, R. Martin, D. Langanke, G. Naumann, and K. Bilek Tumor-associated proteolytic factors uPA and PAI-1 in endometrial carcinoma Gynecol Oncol 66 1997 268 274 (Pubitemid 27335416)
46. M.K. Durand, J.S. Bodker, A. Christensen, D.M. Dupont, M. Hansen, J.K. Jensen, S. Kjelgaard, L. Mathiasen, K.E. Pedersen, S. Skeldal, T. Wind, and P.A. Andreasen Plasminogen activator inhibitor-I and tumour growth, invasion, and metastasis Thromb Haemost 91 2004 438 449 (Pubitemid 38396865)