XMRV induces cell migration, cytokine expression and tumor angiogenesis: Are 22Rv1 cells a suitable prostate cancer model?

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Stieler, Kristin ^a   Schumacher, Udo ^a   Horst, Andrea Kristina ^a   Fischer, Nicole ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL14 CHEMOKINE; CYTOKINE; INTERLEUKIN 13; OSTEOPONTIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER MODEL; CARCINOGENESIS; CELL ASSAY; CELL DIFFERENTIATION; CELL INVASION; CELL MIGRATION; CELL STRAIN; CELL STRAIN 22RV1; CELL TRANSFORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROSTATE CARCINOMA; PROTEIN EXPRESSION; PROTEIN SECRETION; RETROVIRUS; TUMOR NECROSIS; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; VIRUS TRANSCRIPTION; XMRV VIRUS;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL TRANSFORMATION, VIRAL; CYTOKINES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; NECROSIS; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; PROSTATIC NEOPLASMS; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; VIRUS REPLICATION; XENOTROPIC MURINE LEUKEMIA VIRUS-RELATED VIRUS;

GAMMARETROVIRUS; MUS;

EID: 84864400390     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042321     Document Type: Article

References (52)

1. Peehl DM, (2005) Primary cell cultures as models of prostate cancer development. Endocr Relat Cancer 12: 19-47.
2. Horoszewicz JS, Leong SS, Chu TM, Wajsman ZL, Friedman M, et al. (1980) The LNCaP cell line-a new model for studies on human prostatic carcinoma. Prog Clin Biol Res 37: 115-132.
3. Kaighn ME, Narayan KS, Ohnuki Y, Lechner JF, Jones LW, (1979) Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest Urol 17: 16-23.
4. Stone KR, Mickey DD, Wunderli H, Mickey GH, Paulson DF, (1978) Isolation of a human prostate carcinoma cell line (DU 145). Int J Cancer 21: 274-281.
5. Sramkoski RM, Pretlow TG, 2nd, Giaconia JM, Pretlow TP, Schwartz S, et al (1999) A new human prostate carcinoma cell line, 22Rv1. In Vitro Cell Dev Biol Anim 35: 403-409.
6. Knouf EC, Metzger MJ, Mitchell PS, Arroyo JD, Chevillet JR, et al. (2009) Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells. J Virol 83: 7353-7356.
7. Paprotka T, Delviks-Frankenberry KA, Cingoz O, Martinez A, Kung HJ, et al. (2011) Recombinant origin of the retrovirus XMRV. Science 333: 97-101.
8. Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, et al. (2006) Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PLoS Pathog 2: e25.
9. Schlaberg R, Choe DJ, Brown KR, Thaker HM, Singh IR, (2009) XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors. Proc Natl Acad Sci U S A 106: 16351-16356.
10. Aloia AL, Sfanos KS, Isaacs WB, Zheng Q, Maldarelli F, et al. (2010) XMRV: a new virus in prostate cancer? Cancer Res 70: 10028-10033.
11. Farley SJ, (2011) Prostate cancer: XMRV-contaminant, not cause? Nat Rev Urol 8: 409.
12. Fischer N, Hellwinkel O, Schulz C, Chun FK, Huland H, et al. (2008) Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer. J Clin Virol 43: 277-283.
13. Garson JA, Kellam P, Towers GJ, (2011) Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection. Retrovirology 8: 13.
14. Hohn O, Krause H, Barbarotto P, Niederstadt L, Beimforde N, et al. (2009) Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients. Retrovirology 6: 92.
15. Kenyon JC, Lever AM, (2011) XMRV, prostate cancer and chronic fatigue syndrome. Br Med Bull 98: 61-74.
16. Mo F, Wyatt AW, Wu C, Lapuk AV, Marra MA, et al. (2011) Next generation sequencing of prostate tumours provides independent evidence of XMRV contamination. J Clin Microbiol.
17. Sakuma T, Hue S, Squillace KA, Tonne JM, Blackburn PR, et al. (2011) No evidence of XMRV in prostate cancer cohorts in the Midwestern United States. Retrovirology 8: 23.
18. Stieler K, Schindler S, Schlomm T, Hohn O, Bannert N, et al. (2011) No detection of XMRV in blood samples and tissue sections from prostate cancer patients in Northern Europe. PLoS One 6: e25592.
19. Verhaegh GW, de Jong AS, Smit FP, Jannink SA, Melchers WJ, et al. (2011) Prevalence of human xenotropic murine leukemia virus-related gammaretrovirus (XMRV) in Dutch prostate cancer patients. Prostate 71: 415-420.
20. Hue S, Gray ER, Gall A, Katzourakis A, Tan CP, et al. (2010) Disease-associated XMRV sequences are consistent with laboratory contamination. Retrovirology 7: 111.
21. Liu T, Xu F, Du X, Lai D, Zhao Y, et al. (2010) Establishment and characterization of multi-drug resistant, prostate carcinoma-initiating stem-like cells from human prostate cancer cell lines 22RV1. Mol Cell Biochem 340: 265-273.
22. Marcias G, Erdmann E, Lapouge G, Siebert C, Barthelemy P, et al. (2010) Identification of novel truncated androgen receptor (AR) mutants including unreported pre-mRNA splicing variants in the 22Rv1 hormone-refractory prostate cancer (PCa) cell line. Hum Mutat 31: 74-80.
23. Yu JD, Yang K, Mao QQ, Kong DB, Zheng XY, et al. (2009) Estrogen in combination with 5-azacitidine up-regulates p75NTR expression and induces apoptosis in 22Rv1 prostate cancer cells. Mol Med Report 2: 831-836.
24. Kozak CA, (2010) The mouse "xenotropic" gammaretroviruses and their XPR1 receptor. Retrovirology 7: 101.
25. Yan Y, Knoper RC, Kozak CA, (2007) Wild mouse variants of envelope genes of xenotropic/polytropic mouse gammaretroviruses and their XPR1 receptors elucidate receptor determinants of virus entry. J Virol 81: 10550-10557.
26. Yang J, Battacharya P, Singhal R, Kandel ES, (2011) Xenotropic murine leukemia virus-related virus (XMRV) in prostate cancer cells likely represents a laboratory artifact. Oncotarget 2: 358-362.
27. Weber K, Bartsch U, Stocking C, Fehse B, (2008) A multicolor panel of novel lentiviral "gene ontology" (LeGO) vectors for functional gene analysis. Mol Ther 16: 698-706.
28. Tuxhorn JA, Ayala GE, Smith MJ, Smith VC, Dang TD, et al. (2002) Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res 8: 2912-2923.
29. Gerdes MJ, Larsen M, Dang TD, Ressler SJ, Tuxhorn JA, et al. (2004) Regulation of rat prostate stromal cell myodifferentiation by androgen and TGF-beta1. Prostate 58: 299-307.
30. Stieler K, Fischer N, (2010) Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV. PLoS One 5: e11738.
31. Stieler K, Schulz C, Lavanya M, Aepfelbacher M, Stocking C, et al. (2010) Host range and cellular tropism of the human exogenous gammaretrovirus XMRV. Virology 399: 23-30.
32. Erlwein O, Kaye S, McClure MO, Weber J, Wills G, et al. (2010) Failure to detect the novel retrovirus XMRV in chronic fatigue syndrome. PLoS One 5: e8519.
33. Groom HC, Boucherit VC, Makinson K, Randal E, Baptista S, et al. (2010) Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome. Retrovirology 7: 10.
34. Hohn O, Bannert N, (2011) Origin of XMRV and its demise as a human pathogen associated with chronic fatigue syndrome. Viruses 3: 1312-1319.
35. Hohn O, Strohschein K, Brandt AU, Seeher S, Klein S, et al. (2010) No evidence for XMRV in German CFS and MS patients with fatigue despite the ability of the virus to infect human blood cells in vitro. PLoS One 5: e15632.
36. Sfanos KS, Aloia AL, De Marzo AM, Rein A, (2012) XMRV and prostate cancer-a 'final' perspective. Nat Rev Urol 9: 111-118.
37. van Kuppeveld FJ, van der Meer JW, (2012) XMRV and CFS-the sad end of a story. Lancet 379: e27-28.
38. Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, et al. (2006) Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441: 537-541.
39. Metzger MJ, Miller AD, (2010) Acutely transforming retrovirus expressing Nras generated from HT-1080 fibrosarcoma cells infected with the human retrovirus XMRV. J Virol 84: 7908-7910.
40. Pandhare-Dash J, Mantri CK, Gong Y, Chen Z, Dash C, (2011) XMRV accelerates cellular proliferation, transformational activity, and invasiveness of prostate cancer cells by downregulating p27(Kip1). Prostate.
41. Vaughan AE, Mendoza R, Aranda R, Battini JL, Miller AD, (2012) Xpr1 is an atypical G-protein-coupled receptor that mediates xenotropic and polytropic murine retrovirus neurotoxicity. J Virol 86: 1661-1669.
42. Cmarik JL, Troxler JA, Hanson CA, Zhang X, Ruscetti SK, (2011) The human lung adenocarcinoma cell line EKVX produces an infectious xenotropic murine leukemia virus. Viruses 3: 2442-2461.
43. Dong B, Silverman RH, Kandel ES, (2008) A natural human retrovirus efficiently complements vectors based on murine leukemia virus. PLoS One 3: e3144.
44. Lusso P, di Marzo Veronese F, Ensoli B, Franchini G, Jemma C, et al. (1990) Expanded HIV-1 cellular tropism by phenotypic mixing with murine endogenous retroviruses. Science 247: 848-852.
45. Raisch KP, Pizzato M, Sun HY, Takeuchi Y, Cashdollar LW, et al. (2003) Molecular cloning, complete sequence, and biological characterization of a xenotropic murine leukemia virus constitutively released from the human B-lymphoblastoid cell line DG-75. Virology 308: 83-91.
46. Sato E, Furuta RA, Miyazawa T, (2010) An endogenous murine leukemia viral genome contaminant in a commercial RT-PCR Kit is amplified using standard primers for XMRV. Retrovirology 7: 110.
47. Takeuchi Y, McClure MO, Pizzato M, (2008) Identification of gammaretroviruses constitutively released from cell lines used for human immunodeficiency virus research. J Virol 82: 12585-12588.
48. Sfanos KS, Aloia AL, Hicks JL, Esopi DM, Steranka JP, et al. (2011) Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines. PLoS One 6: e20874.
49. Traversari C, Carbone G, Della Torre G, Bergomi M, Parmiani G, et al. (1989) Expression of retrovirus-related, cytotoxic T lymphocyte- and transplantation-defined antigens in NIH/3T3 transfectants after a single passage in nude mice. J Immunol 142: 2887-2894.
50. Tuxhorn JA, McAlhany SJ, Yang F, Dang TD, Rowley DR, (2002) Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model. Cancer Res 62: 6021-6025.
51. Tuxhorn JA, McAlhany SJ, Dang TD, Ayala GE, Rowley DR, (2002) Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model. Cancer Res 62: 3298-3307.
52. Bosselman RA, Hsu RY, Boggs T, Hu S, Bruszewski J, et al. (1989) Replication-defective vectors of reticuloendotheliosis virus transduce exogenous genes into somatic stem cells of the unincubated chicken embryo. J Virol 63: 2680-2689.