Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats

BMB Reports

Volumn 45, Issue 6, 2012, Pages 348-353

  Kim, In Hee ^a   Kim, Dae Ghon ^a   Hao, Peipei ^a   Wang, Yunpeng ^a   Kim, Seong Hun ^a   Kim, Sang Wook ^a   Lee, Seung Ok ^a   Lee, Soo Teik ^a  

^a Chonbuk National University Medical School   (South Korea)

Author keywords

L 2 Oxothiazolidine 4 carboxylic acid; Liver fibrosis; Nrf2; Oxidative stress; Thioacetamide

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; 2-OXOTHIAZOLIDINE-4-CARBOXYLIC ACID; ACTIN; ANTIFIBRINOLYTIC AGENT; COLLAGEN TYPE 1; HEME OXYGENASE 1; MALONALDEHYDE; PYROGLUTAMIC ACID; THIAZOLIDINE DERIVATIVE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; EXPERIMENTAL LIVER CIRRHOSIS; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT; UPREGULATION;

ACTINS; ANIMALS; ANTIFIBRINOLYTIC AGENTS; COLLAGEN TYPE I; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MALONDIALDEHYDE; NF-E2-RELATED FACTOR 2; PYRROLIDONECARBOXYLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; THIAZOLIDINES; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

RATTUS;

EID: 84864393625     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2012.45.6.276     Document Type: Article

References (25)

1. Friedman, S. L. (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275, 2247-2250.
2. Bataller, R. and Brenner, D. A. (2001) Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin. Liver. Dis. 21, 437-451.
3. Gressner, A. M. and Weiskirchen, R. (2006) Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets. J. Cell. Mol. Med. 10, 76-99.
4. Urtasun, R., Conde de la Rosa, L. Nieto, N. (2008) Oxidative and nitrosative stress and fibrogenic response. Clin. Liver Dis. 12, 769-790.
5. Tilg, H. and Diehl, A. M. (2000) Cytokines in alcoholic and nonalcoholic steatohepatitis. N. Engl. J. Med. 343, 1467-1476.
6. Kawada, N., Seki, S., Inoue, M. and Kuroki, T. (1998) Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology 27, 1265-1274.
7. Tahan, G., Tarcin, O., Tahan, V., Eren, F., Gedik, N., Sahan, E., Biberoglu, N., Guzel, S., Bozbas, A., Tozun, N. and Yucel, O. (2007) The effects of N-acetylcysteine on bile-duct ligation-induced liver fibrosis in rats. Dig. Dis. Sci. 52, 3348-3354.
8. Yamazaki, H., Oda, Y., Funae, Y., Imaoka, S., Inui, Y. and Guengerich, F. P. (1992) Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosdimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain. Carcinogenesis 13, 979-985.
9. Aleksunes, L. M. and Manautou, J. E. (2007) Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease. Toxicol. Pathol. 35, 459-473.
10. Klaassen, C. D. and Reisman, S. A. (2010) Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicol. Appl. Pharmacol. 244, 57-65.
11. Jaiswal, A. (2004) Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic. Biol. Med. 36, 1199-1207.
12. Meister, A., Anderson, M. E. and Hwang, O. (1986) Intracellular cysteine and glutathione delivery systems. J. Am. Coll. Nutr. 5, 137-151.
13. Leaf, C. D. and Pace, G. W. (1994) Development of a novel glutathione repleting agent, L-2-oxothiazolidine-4-caboxylic acid (Procysteine). Exp. Opin. Invest. Drugs. 3, 1293-1302.
14. Mesina, J. E., Page, R. H., Hetzel, F. W. and Chopp, M. (1989) Administration of L-2-oxothiazolidine-4-caroxylate increases glutathione levels in rat brain. Brain Res. 478, 181-183.
15. Iimuro, Y., Bradford, B. U., Yamashina, S., Rusyn, I., Nakagami, M., Enomoto, N., Kono, H., Frey, W., Forman, D., Brenner, D. and Thurman, R. G. (2000) The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Hepatology 31, 391-398.
16. Bataller, R. and Brenner, D. A. (2005) Liver fibrosis. J. Clin. Invest. 115, 209-218.
17. Breitkopf, K., Haas, S., Wiercinska, E., Singer, M. V. and Dooley, S. (2005) Anti-TGF-beta strategies for the treatment of chronic liver disease. Alcohol. Clin. Exp. Res. 29(11 Suppl), S121-S131.
18. George, J., Roulot, D., Koteliansky, V. E. and Bissell, D. M. (1999) In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis. Proc. Natl. Acad. Sci. U.S.A. 96, 12719-12724.
19. Muriel, P. (2009) Role of free radicals in liver diseases. Hepatol. Int. 3, 526-536.
20. Nieto, N., Friedman, S. L. and Cederbaum, A. I. (2002) Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome p450 2e1-derived reactive oxygen species. Hepatology 35, 62-73.
21. Mates, J. M. (2000) Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153, 83-104.
22. Singal, A. K., Jampana, S. C. and Weinman, S. A. (2011) Antioxidants as therapeutic agents for liver disease. Liver Int. 31, 1432-1438.
23. Farombi, E. O., Shrotriya, S., Na, H. K., Kim, S. H. and Surh, Y. J. (2008) Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem. Toxicol. 46, 1279-1287.
24. Lee, S., Moon, S. O., Kim, W., Sung, M. J., Kim, D. H., Kang, K. P., Jang, Y. B., Lee, J. E., Jang, K. Y., Lee, S. Y. and Park, S. K. (2006) Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury. Nephrol. Dial. Transplant. 21, 2085-2095.
25. Scheuer, P. J. (1991) Classification of chronic viral hepatitis: a need for reassessment. J. Hepatol. 13, 372-374.