Zoledronate inhibits ischemia-induced neovascularization by impairing the mobilization and function of endothelial progenitor cells

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Tsai, Shih Hung ^a,b   Huang, Po Hsun ^b,c   Chang, Wei Chou ^a   Tsai, Hsiao Ya ^b   Lin, Chih Pei ^b,c   Leu, Hsin Bang ^b,c   Wu, Tao Cheng ^b,c   Chen, Jaw Wen ^b,c   Lin, Shing Jong ^b,c  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE B; PROTEIN KINASE B; VASCULOTROPIN; ZOLEDRONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CAPILLARY DENSITY; CELL AGING; CELL ASSAY; CELL FUNCTION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DOPPLER FLOWMETRY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; ENDOTHELIAL PROGENITOR CELL; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMOBILIZED CELL; IN VITRO STUDY; LIMB ISCHEMIA; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; TISSUE BLOOD FLOW;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; DIPHOSPHONATES; ENDOTHELIAL CELLS; HINDLIMB; IMIDAZOLES; ISCHEMIA; MATRIX METALLOPROTEINASE 9; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; STEM CELLS;

MUS;

EID: 84864340723     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041065     Document Type: Article

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