Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation

British Journal of Cancer

Volumn 107, Issue 3, 2012, Pages 501-507

  Sadanandam, A ^a,b,c   Sidhu, S S ^d   Wullschleger, S ^c   Singh, S ^a   Varney, M L ^a   Yang, C S ^a   Ashour, A E ^e   Batra, S K ^a   Singh, R K ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^c EPFL   (Switzerland)

^d INSERM   (France)

^e KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

angiogenic factors; pancreatic cancer; reduced tumour burden; secreted SEMA5A; semaphorin; tumour burden and metastasis

Indexed keywords

SEMAPHORIN; SEMAPHORIN 5A; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER METASTASIS; METASTASIS; PANCREAS TUMOR; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR VOLUME;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; CELL GROWTH PROCESSES; DISEASE PROGRESSION; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTERLEUKIN-8; LIVER NEOPLASMS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM MICROMETASTASIS; NEOVASCULARIZATION, PATHOLOGIC; NERVE TISSUE PROTEINS; PANCREATIC NEOPLASMS; PHOSPHORYLATION; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84864338143     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2012.298     Document Type: Article

References (32)

1. Adams RH, Betz H, Puschel AW (1996) A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. Mech Dev 57: 33-45
2. Ades EW, Candal FJ, Swerlick RA, George VG, Summers S, Bosse DC, Lawley TJ (1992) HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 99: 683-690
3. Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, Comoglio PM, Tamagnone L (2004) Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep 5: 710-714
4. Bandyopadhyay A, Zhu Y, Malik SN, Kreisberg J, Brattain MG, Sprague EA, Luo J, Lopez-Casillas F, Sun LZ (2002) Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells. Oncogene 21: 3541-3551
5. Basile JR, Barac A, Zhu T, Guan KL, Gutkind JS (2004) Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Res 64: 5212-5224
6. Basile JR, Castilho RM, Williams VP, Gutkind JS (2006) Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. Proc Natl Acad Sci USA 103: 9017-9022
7. Brambilla E, Constantin B, Drabkin H, Roche J (2000) Semaphorin SEMA3F localization in malignant human lung and cell lines: a suggested role in cell adhesion and cell migration. Am J Pathol 156: 939-950
8. Chen H, He Z, Tessier-Lavigne M (1998) Axon guidance mechanisms: semaphorins as simultaneous repellents and anti-repellents. Nat Neurosci 1: 436-439
9. Chiang WF, Liu SY, Fang LY, Lin CN, Wu MH, Chen YC, Chen YL, Jin YT (2008) Overexpression of galectin-1 at the tumor invasion front is associated with poor prognosis in early-stage oral squamous cell carcinoma. Oral Oncol 44: 325-334
10. Christensen CR, Klingelhofer J, Tarabykina S, Hulgaard EF, Kramerov D, Lukanidin E (1998) Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. Cancer Res 58: 1238-1244
11. Kolodkin AL, Matthes DJ, Goodman CS (1993) The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell 75: 1389-1399
12. Kusy S, Nasarre P, Chan D, Potiron V, Meyronet D, Gemmill RM, Constantin B, Drabkin HA, Roche J (2005) Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells. Neoplasia 7: 457-465
13. Li X, Lee AY (2010) Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase. J Biol Chem 285: 32436-32445
14. Lu TP, Tsai MH, Lee JM, Hsu CP, Chen PC, Lin CW, Shih JY, Yang PC, Hsiao CK, Lai LC, Chuang EY (2010) Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women. Cancer Epidemiol Biomarkers Prev 19: 2590-2597
15. Melin M, Carlsson B, Anckarsater H, Rastam M, Betancur C, Isaksson A, Gillberg C, Dahl N (2006) Constitutional downregulation of SEMA5A expression in autism. Neuropsychobiology 54: 64-69
16. Menz J, Sterrett G, Wall L (1985) Metastatic basal cell carcinoma associated with a small primary tumour. Australas J Dermatol 26: 121-124
17. Oster SF, Bodeker MO, He F, Sretavan DW (2003) Invariant Sema5A inhibition serves an ensheathing function during optic nerve development. Development 130: 775-784
18. Pan G, Lv H, Ren H, Wang Y, Liu Y, Jiang H, Wen J (2010) Elevated expression of semaphorin 5A in human gastric cancer and its implication in carcinogenesis. Life Sci 86: 139-144
19. Roth L, Koncina E, Satkauskas S, Cremel G, Aunis D, Bagnard D (2009) The many faces of semaphorins: from development to pathology. Cell Mol Life Sci 66: 649-666
20. Sadanandam A, Rosenbaugh EG, Singh S, Varney M, Singh RK (2010a) Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. Microvasc Res 79: 1-9
21. Sadanandam A, Varney ML, Kinarsky L, Ali H, Mosley RL, Singh RK (2007) Identification of functional cell adhesion molecules with a potential role in metastasis by a combination of in vivo phage display and in silico analysis. Omics 11: 41-57
22. Sadanandam A, Varney ML, Singh RK (2008) Identification of semaphorin 5A interacting protein by applying apriori knowledge and peptide complementarity related to protein evolution and structure. Genomics Proteomics Bioinformatics 6: 163-174
23. Sadanandam A, Varney ML, Singh S, Ashour AE, Moniaux N, Deb S, Lele SM, Batra SK, Singh RK (2010b) High gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion and metastasis. Int J Cancer 127: 1373-1383
24. Sho M, Adachi M, Taki T, Hashida H, Konishi T, Huang CL, Ikeda N, Nakajima Y, Kanehiro H, Hisanaga M, Nakano H, Miyake M (1998) Transmembrane 4 superfamily as a prognostic factor in pancreatic cancer. Int J Cancer 79: 509-516
25. Stathis A, Moore MJ (2010) Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev Clin Oncol 7: 163-172
26. Stickeler E, Vogl FD, Denkinger T, Mobus VJ, Kreienberg R, Runnebaum IB (2000) Soluble CD44 splice variants and pelvic lymph node metastasis in ovarian cancer patients. Int J Mol Med 6: 595-601
27. Sugimoto M, Fujikawa A, Womack JE, Sugimoto Y (2006) Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance. Proc Natl Acad Sci USA 103: 6454-6459
28. Tamagnone L, Comoglio PM (2000) Signalling by semaphorin receptors: cell guidance and beyond. Trends Cell Biol 10: 377-383
29. Varney ML, Li A, Dave BJ, Bucana CD, Johansson SL, Singh RK (2003) Expression of CXCR1 and CXCR2 receptors in malignant melanoma with different metastatic potential and their role in interleukin-8 (CXCL-8)-mediated modulation of metastatic phenotype. Clin Exp Metastasis 20: 723-731
30. Wang X, Kumanogoh A, Watanabe C, Shi W, Yoshida K, Kikutani H (2001) Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses. Blood 97: 3498-3504
31. Woodhouse EC, Fisher A, Bandle RW, Bryant-Greenwood B, Charboneau L, Petricoin III EF, Liotta LA (2003) Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype. Proc Natl Acad Sci USA 100: 11463-11468
32. Yazdani U, Terman JR (2006) The semaphorins. Genome Biol 7: 211