Subclinical hypothyroidism in children and adolescents: A wide range of clinical, biochemical, and genetic factors involved

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 7, 2009, Pages 2414-2420

  Rapa, Anna ^a   Monzani, Alice ^a   Moia, Stefania ^a   Vivenza, Daniela ^a   Bellone, Simonetta ^a   Petri, Antonella ^a   Teofoli, Francesca ^b   Cassio, Alessandra ^c,e   Cesaretti, Graziano ^d   Corrias, Andrea ^c,e   De Sanctis, Vincenzo ^f   Maio, Salvatore Di ^g   Volta, Cecilia ^h   Wasniewska, Malgorzata ⁱ   Tatò, Luciano ^b   Bona, Gianni ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d UNIVERSITY OF PISA   (Italy)

^e UNIVERSITY OF TURIN   (Italy)

^f UNIVERSITY HOSPITAL OF FERRARA   (Italy)

^g SANTOBONO PAUSILIPON CHILDREN S HOSPITAL   (Italy)

^h UNIVERSITY OF PARMA   (Italy)

ⁱ UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE; LIOTHYRONINE; THYROGLOBULIN ANTIBODY; THYROID ANTIBODY; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROTROPIN RECEPTOR; THYROXINE;

ADOLESCENT; ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; BODY HEIGHT; BODY WEIGHT; CHILD; ECHOGRAPHY; EXON; FAMILY HISTORY; FEMALE; GENE MUTATION; GENETIC ANALYSIS; GENETIC VARIABILITY; HUMAN; HYPOTHYROIDISM; INFANT; LIOTHYRONINE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OBESITY; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; SCHOOL CHILD; THYROID DISEASE; THYROID WEIGHT; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; URINARY EXCRETION; URINE LEVEL;

EID: 67650257691     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0375     Document Type: Article

References (39)

1. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, Franklyn JA, Hershman JM, Burman KD, Denke MA, Gorman C, Cooper RS, Weissman NJ 2004 Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 291:228-238
2. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC 2000 The Colorado thyroid disease prevalence study. Arch Intern Med 160:526-534
3. Paoli-Valeri M, Maman-Alvardo D, Jiménez-Lopez V, Arias-Ferreira A, Bianchi G, Arata-Bellabarba G 2003 Frequency of subclinical hypothyroidism among healthy children and those with neurological conditions in the state of Mérida, Venezuela. Invest Clin 44:209-218
4. Wu T, Flowers JW, Tudiver F, Wilson JL, Punyasavatsut N 2006 Subclinical thyroid disorders and cognitive performance among adolescents in the United States. BMC Pediatr 6:12
5. Zulewski H, Múller B, Exer P, Miserez AR, Staub JJ 1997 Estimation of tissue hypothyroidism by a new clinical score: evaluation of patients with various grades of hypothyroidism and controls. J Clin Endocrinol Metab 82:771-776
6. Cooper DS 2001 Clinical practice. Subclinical hypothyroidism. N Engl J Med 345:260-265
7. Aijaz NJ, Flaherty EM, Preston T, Bracken SS, Lane AH, Wilson TA 2006 Neurocognitive function in children with compensated hypothyroidism: lack of short term effects on or off thyroxin. BMC Endocr Disord 6:2
8. Arrigo T, Wasniewska M, Crisafulli G, Lombardo F, Messina MF, Rulli I, Salzano G, Valenzise M, Zirilli G, De Luca F 2008 Subclinical hypothyroidism: the state of the art. J Endocrinol Invest 31:79-84
9. Alberti L, Proverbio MC, Costagliola S, Romoli R, Boldrighini B, Vigone MC, Weber G, Chiumello G, Beck-Peccoz P, Persani L 2002 Germline mutations of TSH receptor gene as cause of nonautoimmune subclinical hypothyroidism. J Clin Endocrinol Metab 87:2549-2555
10. Duprez L, Parma J, Van Sande J, Rodien P, Dumont JE, Vassart G, Abramowicz M 1998 TSH receptor mutations and thyroid disease. Trends Endocrinol Metab 9:133-140
11. Tonacchera M, Di Cosmo C, De Marco G, Agretti P, Banco M, Perri A, Gianetti E, Montanelli L, Vitti P, Pinchera A 2007 Identification of TSH receptor mutations in three families with resistance to TSH. Clin Endocrinol (Oxf) 67:712-718
12. Clifton-Bligh RJ, Gregory JW, Ludgate M, John R, Persani L, Asteria C, Beck-Peccoz P, Chatterjee VK 1997 Two novel mutations in the thyrotropin (TSH) receptor gene in a child with resistance to TSH. J Clin Endocrinol Metab 82:1094-1100
13. Camilot M, Teofoli F, Gandini A, Franceschi R, Rapa A, Corrias A, Bona G, Radetti G, Tatò L 2005 Thyrotropin receptor gene mutations and TSH resistance: variable expressivity in the heterozygotes. Clin Endocrinol (Oxf) 63:146-151
14. Cacciari E, Milani S, Balsamo A, Spada E, Bona G, Cavallo L, Cerutti F, Gargantini L, Greggio N, Tonini G, Cicognani A 2006 Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). J Endocrinol Invest 29:581-593
15. Zimmermann MB, Hess SY, Molinari L, De Benoist B, Delange F, Braverman LE, Fujieda K, Ito Y, Jooste PL, Moosa K, Pearce EN, Pretell EA, Shishiba Y 2004 New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: a World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report. Am J Clin Nutr 79:231-237
16. Knudsen N, Christiansen E, Brandt-Christensen M, Nygaard B, Perrild H 2000 Age- and sex-adjusted iodine/creatinine ratio. A new standard in epidemiological surveys? Evaluation of three different estimates of iodine excretion based on casual urine samples and comparison to 24 h values. Eur J Clin Nutr 54:361-363
17. Mage DT, Allen RH, Kodali A 2008 Creatinine corrections for estimating children's and adult's pesticide intake doses in equilibrium with urinary pesticide and creatinine concentrations. J Expo Sci Environ Epidemiol 18:360-368
18. Maffeis C, Banzato C, Talamini G; Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology 2008 Waist-to-height ratio, a useful index to identify high metabolic risk in overweight children. J Pediatr 152:207-213
19. Reinehr T, de Sousa G, Andler W 2006 Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids. J Clin Endocrinol Metab 91:3088-3091
20. Radetti G, Kleon W, Buzi F, Crivellaro C, Pappalardo L, di Iorgi N, Maghnie M 2008 Thyroid function and structure are affected in childhood obesity. J Clin Endocrinol Metab 93:4749-4754
21. Nillni EA, Vaslet C, Harris M, Hollenberg A, Bjørbak C, Flier JS 2000 Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways. J Biol Chem 275:36124-36133
22. Burman KD, Latham KR, Djuh YY, Smallridge RC, Tseng YC, Lukes YG, Maunder R, Wartofsky L 1980 Solubilized nuclear thyroid hormone receptors in circulating human mononuclear cells. J Clin Endocrinol Metab 51:106-116
23. Krotkiewski M 2002 Thyroid hormones in the pathogenesis and treatment of obesity. Eur J Pharmacol 440:85-98
24. Wit JM, Clayton PE, Rogol AD, Savage MO, Saenger PH, Cohen P 2008 Idiopathic short stature: definition, epidemiology, and diagnostic evaluation. Growth Horm IGF Res 18:89-110
25. Cetinkaya E, Aslan A, Vidinlisan S, Ocal G 2003 Height improvement by L-thyroxine treatment in subclinical hypothyroidism. Pediatr Int 45:534-537
26. Loy M, Cianchetti ME, Cardia F, Melis A, Boi F, Mariotti S 2004 Correlation of computerized grey-scale sonographic findings with thyroid function and thyroid autoimmune activity in patients with Hashimoto's thyroiditis. J Clin Ultrasound 32:136-140
27. Rago T, Chiovato L, Grasso L, Pinchera A, Vitti P 2001 Thyroid ultrasonography as a tool for detecting thyroid autoimmune diseases and predicting thyroid dysfunction in apparently healthy subjects. J Endocrinol Invest 24:763-769
28. Vejbjerg P, Knudsen N, Perrild H, Laurberg P, Pedersen IB, Rasmussen LB, Ovesen L, Jørgensen T 2006 The association between hypoechogenicity or irregular echo pattern at thyroid ultrasonography and thyroid function in the general population. Eur J Endocrinol 155:547-552
29. Kershaw EE, Flier JS 2004 Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89:2548-2556
30. Chrousos GP 1995 The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332:1351-1362
31. Pekary AE, Hershman JM 1998 Tumor necrosis factor, ceramide, transforming growth factor-β1, and aging reduce Na+/I-symporter messenger ribonucleic acid levels in FRTL-5 cells. Endocrinology 139:703-712
32. World Health Organization, UNICEF, ICCIDD 2008 Assessment of iodine deficiency disorders and monitoring their elimination. A guide for programme managers. http://www.who.int/nutrition/publications/micronutrients/ iodine-deficiency/9789241595827/en/index.html
33. Grasberger H, Mimouni-Bloch A, Vantyghem MC, van Vliet G, Abramowicz M, Metzger DL, Abdullatif H, Rydlewski C, Macchia PE, Scherberg NH, van Sande J, Mimouni M, Weiss RE, Vassart G, Refetoff S 2005 Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization and exclusion of candidate loci. J Clin Endocrinol Metab 90:4025-4034
34. Calebiro D, de Filippis T, Lucchi S, Covino C, Panigone S, Beck-Peccoz P, Dunlap D, Persani L 2005 Intracellular entrapment of wild-type TSH receptor by oligomerization with mutants linked to dominant TSH resistance. Hum Mol Genet 14:2991-3002
35. De Marco G, Agretti P, Camilot M, Teofoli F, Tatò L, Vitti P, Pinchera A, Tonacchera M 2009 Functional studies of new TSH receptor (TSHr) mutations identified in patients affected by hypothyroidism or isolated hyperthyrotropinaemia. Clin Endocrinol (Oxf) 70:335-338
36. Teofoli F, Camilot M, Tatò L 2007 Lack of association between thyrotropin receptor gene polymorphisms and subclinical hypothyroidism in children. J Endocrinol Invest 30:163-166
37. Esperante SA, Rivolta CM, Caputo M, González-Sarmiento R, Targovnik HM 2008 Identification and characterization of new variants of three associated SNPs and a microsatellite in the TSH receptor gene which are useful for genetic studies. Mol Cell Probes 22:281-286
38. Nagasaki K, Narumi S, Asami T, Kikuchi T, Hasegawa T, Uchiyama M 2008 Mutation of a gene for thyroid transcription factor-1 (TITF1) in a patient with clinical features of resistance to thyrotropin. Endocr J 55:875-878
39. Arnaud-Lopez L, Usala G, Ceresini G, Mitchell BD, Pilia MG, Piras MG, Sestu N, Maschio A, Busonero F, Albai G, Dei M, Lai S, Mulas A, Crisponi L, Tanaka T, Bandinelli S, Guralnik JM, Loi A, Balaci L, Sole G, Prinzis A, Mariotti S, Shuldiner AR, Cao A, Schlessinger D, Uda M, Abecasis GR, Nagaraja R, Sanna S, Naitza S 2008 Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. Am J Hum Genet 82:1270-1280