Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization

Journal of Membrane Biology

Volumn 245, Issue 5-6, 2012, Pages 221-230

  Smith, Tekla D ^a   Mohankumar, Aditi ^b   Minogue, Peter J ^b   Beyer, Eric C ^b   Berthoud, Viviana M ^b   Koval, Michael ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Chaperone; Endothelium; ERp29; Membrane traffic; Quality control

Indexed keywords

AMINO ACID; BREFELDIN A; CONNEXIN 37; CONNEXIN 40; MUTANT PROTEIN;

AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; OLIGOMERIZATION; PROTEIN EXPRESSION; PROTEIN MOTIF; VASCULARIZATION;

AMINO ACIDS; CELL MEMBRANE; CONNEXIN 43; CONNEXINS; CYTOSOL; FLUORESCENT ANTIBODY TECHNIQUE; GAP JUNCTIONS; HUMANS; PROTEIN MULTIMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864328472     PISSN: 00222631     EISSN: 14321424     Source Type: Journal    
DOI: 10.1007/s00232-012-9443-5     Document Type: Article

References (41)

1. Beyer EC, Berthoud VM (2009) The family of connexin genes. In: Harris AL, Locke D (eds) Connexins: a guide. Humana Press, New York, pp 3-26
2. Beyer EC, Gemel J, Martinez A, Berthoud VM, Valiunas V, Moreno AP, Brink PR (2001) Heteromeric mixing of connexins: compatibility of partners and functional consequences. Cell Commun Adhes 8:199-204
3. Brisset AC, Isakson BE, Kwak BR (2009) Connexins in vascular physiology and pathology. Antioxid Redox Signal 11:267-282
4. Chen J, Anderson JB, Defieese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler-Bauer A, Marchler GH, Mazumder R, Nikolskaya AN, Rao BS, Panchenko AR, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH (2003) MMDB: Entrez's 3D-structure database. Nucleic Acids Res 31:474-477 (Pubitemid 36150433)
5. Cottrell GT, Burt JM (2005) Functional consequences of heterogeneous gap junction channel formation and its influence in health and disease. Biochim Biophys Acta 1711:126-141 (Pubitemid 40799288)
6. Das Sarma J, Wang F, Koval M (2002) Targeted gap junction protein constructs reveal connexin-specific differences in oligomerization. J Biol Chem 277:20911-20918 (Pubitemid 34967400)
7. Das S, Smith TD, Das Sarma J, Ritzenthaler JD, Maza J, Kaplan BE, Cunningham LA, Suaud L, Hubbard MJ, Rubenstein RC, Koval M (2009) ERp29 restricts connexin43 oligomerization in the endoplasmic reticulum. Mol Biol Cell 20:2593-2604
8. Das Sarma J, Das S, Koval M (2005) Regulation of connexin43 oligomerization is saturable. Cell Commun Adhes 12:237-247
9. Das Sarma J, Kaplan BE, Willemsen D, Koval M (2008) Identification of rab20 as a potential regulator of connexin43 trafficking. Cell Commun Adhes 15:65-74
10. Daugherty BL, Ward C, Smith T, Ritzenthaler JD, Koval M (2007) Regulation of heterotypic claudin compatibility. J Biol Chem 282:30005-30013 (Pubitemid 350035274)
11. Figueroa XF, Isakson BE, Duling BR (2004) Connexins: gaps in our knowledge of vascular function. Physiology (Bethesda) 19: 277-284 (Pubitemid 39472639)
12. Gabriels JE, Paul DL (1998) Connexin43 is highly localized to sites of disturbed flow in rat aortic endothelium but connexin37 and connexin40 are more uniformly distributed. Circ Res 83: 636-643 (Pubitemid 28427747)
13. Gemel J, Valiunas V, Brink PR, Beyer EC (2004) Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells. J Cell Sci 117:2469-2480 (Pubitemid 38877843)
14. Gong X, Agopian K, Kumar NM, Gilula NB (1999) Genetic factors influence cataract formation in a3 connexin knockout mice. Dev Genet 24:27-32 (Pubitemid 29115546)
15. Heberlein KR, Straub AC, Isakson BE (2009) The myoendothelial junction: breaking through the matrix? Microcirculation 16:307-322
16. Hirst-Jensen BJ, Sahoo P, Kieken F, Delmar M, Sorgen PL (2007) Characterization of the pH-dependent interaction between the gap junction protein connexin43 carboxyl terminus and cytoplasmic loop domains. J Biol Chem 282:5801-5813 (Pubitemid 47093738)
17. Hoehenwarter W, Tang Y, Ackermann R, Pleissner KP, Schmid M, Stein R, Zimny-Arndt U, Kumar NM, Jungblut PR (2008) Identification of proteins that modify cataract of mouse eye lens. Proteomics 8:5011-5024
18. Isakson BE, Duling BR (2005) Heterocellular contact at the myoendothelial junction influences gap junction organization. Circ Res 97:44-51 (Pubitemid 40982321)
19. Isakson BE, Best AK, Duling BR (2008) Incidence of protein on actin bridges between endothelium and smooth muscle in arterioles demonstrates heterogeneous connexin expression and phosphorylation. Am J Physiol Heart Circ Physiol 294:H2898-H2904
20. Johnson R, Hammer M, Sheridan J, Revel JP (1974) Gap junction formation between reaggregated Novikoff hepatoma cells. Proc Natl Acad Sci USA 71:4536-4540
21. Johnson RG, Reynhout JK, Tenbroek EM, Quade BJ, Yasumura T, Davidson KG, Sheridan JD, Rash JE (2012) Gap junction assembly: roles for the formation plaque and regulation by the C-terminus of connexin43. Mol Biol Cell 23:71-86
22. Johnstone S, Isakson B, Locke D (2009) Biological and biophysical properties of vascular connexin channels. Int Rev Cell Mol Biol 278:69-118
23. Kanter HL, Saffitz JE, Beyer EC (1994) Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45. J Mol Cell Cardiol 26:861-868 (Pubitemid 24223236)
24. Koval M (2006) Pathways and control of connexin oligomerization. Trends Cell Biol 16:159-166 (Pubitemid 43358004)
25. Koval M, Geist ST, Westphale EM, Kemendy AE, Civitelli R, Beyer EC, Steinberg TH (1995) Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43. J Cell Biol 130:987-995
26. Koval M, Harley JE, Hick E, Steinberg TH (1997) Connexin46 is retained as monomers in a trans-Golgi compartment of osteoblastic cells. J Cell Biol 137:847-857 (Pubitemid 27215507)
27. Lagree V, Brunschwig K, Lopez P, Gilula NB, Richard G, Falk MM (2003) Specific amino-acid residues in the N-terminus and TM3 implicated in channel function and oligomerization compatibility of connexin43. J Cell Sci 116:3189-3201 (Pubitemid 37038967)
28. Laird DW (2006) Life cycle of connexins in health and disease. Biochem J 394:527-543
29. Laird DW (2010) The gap junction proteome and its relationship to disease. Trends Cell Biol 20:92-101
30. Maeda S, Nakagawa S, Suga M, Yamashita E, Oshima A, Fujiyoshi Y, Tsukihara T (2009) Structure of the connexin 26 gap junction channel at 3.5 A ° resolution. Nature 458:597-602
31. Martínez AD, Maripillán J, Acuña R, Minogue PJ, Berthoud VM, Beyer EC (2011) Different domains are critical for oligomerization compatibility of different connexins. Biochem J 436: 35-43
32. Maza J, Mateescu M, Sarma JD, Koval M (2003) Differential oligomerization of endoplasmic reticulum-retained connexin43/ connexin32 chimeras. Cell Commun Adhes 10:319-322 (Pubitemid 38081391)
33. Maza J, Das Sarma J, Koval M (2005) Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum. J Biol Chem 280:21115-21121 (Pubitemid 40805671)
34. Minogue PJ, Liu X, Ebihara L, Beyer EC, Berthoud VM (2005) An aberrant sequence in a connexin46 mutant underlies congenital cataracts. J Biol Chem 280:40788-40795 (Pubitemid 41780570)
35. Musil LS, Goodenough DA (1993) Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER. Cell 74:1065-1077 (Pubitemid 23289463)
36. Paznekas WA, Karczeski B, Vermeer S, Lowry RB, Delatycki M, Laurence F, Koivisto PA, Van Maldergem L, Boyadjiev SA, Bodurtha JN, Jabs EW (2009) GJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype. Hum Mutat 30:724-733
37. Reed KE, Westphale EM, Larson DM, Wang HZ, Veenstra RD, Beyer EC (1993) Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein. J Clin Invest 91:997-1004 (Pubitemid 23095274)
38. Severs NJ, Rothery S, Dupont E, Coppen SR, Yeh HI, Ko YS, Matsushita T, Kaba R, Halliday D (2001) Immunocytochemical analysis of connexin expression in the healthy and diseased cardiovascular system. Microsc Res Tech 52:301-322 (Pubitemid 32140399)
39. Wang Y, Addess KJ, Chen J, Geer LY, He J, He S, Lu S, Madej T, Marchler-Bauer A, Thiessen PA, Zhang N, Bryant SH (2007) MMDB: annotating protein sequences with Entrez's 3D-structure database. Nucleic Acids Res 35:D298-D300 (Pubitemid 46056218)
40. Wittig I, Braun HP, Schagger H (2006) Blue native PAGE. Nat Protoc 1:418-428
41. Yeh HI, Rothery S, Dupont E, Coppen SR, Severs NJ (1998) Individual gap junction plaques contain multiple connexins in arterial endothelium. Circ Res 83:1248-1263 (Pubitemid 29006040)