Lipopolysaccharide injection induces rapid decrease of hypothalamic GnRH mRNA and peptide, but does not affect GnIH in zebra finches

Hormones and Behavior

Volumn 62, Issue 2, 2012, Pages 173-179

  Lopes, P C ^a,b   Wingfield, J C ^c   Bentley, G E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endotoxin; HPG axis; Hypothalamus; LPS; Reproduction; Sickness behavior

Indexed keywords

CORTICOSTERONE; GONADORELIN; GONADOTROPHIN INHIBITORY HORMONE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NEUROPEPTIDE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; FINCH; GENE EXPRESSION; HYPOTHALAMUS; MALE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; POEPHILA CASTANOTIS; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL;

ANIMALS; AVIAN PROTEINS; DOWN-REGULATION; FEMALE; FINCHES; GENE EXPRESSION REGULATION; GONADOTROPIN-RELEASING HORMONE; HYPOTHALAMIC HORMONES; HYPOTHALAMUS; INJECTIONS; LIPOPOLYSACCHARIDES; MALE; PEPTIDE FRAGMENTS; RNA, MESSENGER; TIME FACTORS;

EID: 84864300557     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2012.06.007     Document Type: Article

References (41)

1. Adelman J.S., Bentley G.E., Wingfield J.C., Martin L.B., Hau M. Population differences in fever and sickness behaviors in a wild passerine: a role for cytokines. J. Exp. Biol. 2010, 213:4099-4109.
2. Ashley N.T., Hays Q.R., Bentley G.E., Wingfield J.C. Testosterone treatment diminishes sickness behavior in male songbirds. Horm. Behav. 2009, 56:169-176.
3. Ashley N.T., Wingfield J.C. Sickness behavior in vertebrates: allostasis, life history modulation and hormonal regulation. Ecoimmunology 2012, 45-91. Oxford University Press, London. R.J. Nelson, G. Demas (Eds.).
4. Battaglia D.F., Krasa H.B., Padmanabhan V., Viguie C., Karsch F.J. Endocrine alterations that underlie endotoxin-induced disruption of the follicular phase in ewes. Biol. Reprod. 2000, 62:45-53.
5. Beishuizen A., Thijs L.G. Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis. J. Endotoxin Res. 2003, 9:3-24.
6. Bentley G.E., Jensen J.P., Kaur G.J., Wacker D.W., Tsutsui K., Wingfield J.C. Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH). Horm. Behav. 2006, 49:550-555.
7. Bonneaud C., Mazuc J., Gonzalez G., Haussy C., Chastel O., Faivre B., Sorci G. Assessing the cost of mounting an immune response. Am. Nat. 2003, 161:367-379.
8. Burness G., Armstrong C., Fee T., Tilman-Schindel E. Is there an energetic-based trade-off between thermoregulation and the acute phase response in zebra finches?. J. Exp. Biol. 2010, 213:1386-1394.
9. Clarke I.J., Qi Y., Sari I.P., Smith J.T. Evidence that RF-amide related peptides are inhibitors of reproduction in mammals. Front. Neuroendocrinol. 2009, 30:371-378.
10. Coleman E.S., Elsasser T.H., Kemppainen R.J., Coleman D.A., Sartin J.L. Effect of endotoxin on pituitary-hormone secretion in sheep. Neuroendocrinology 1993, 58:111-122.
11. Ebisui O., Fukata J., Tominaga T., Murakami N., Kobayashi H., Segawa H., Muro S., Naito Y., Nakai Y., Masui Y., Nishida T., Imura H. Roles of interleukin-1-alpha and interleukin-1-beta in endotoxin-induced suppression of plasma gonadotropin-levels in rats. Endocrinology 1992, 130:3307-3313.
12. Harris T.G., Battaglia D.F., Brown M.E., Brown M.B., Carlson N.E., Viguie C., Williams C.Y., Karsch F.J. Prostaglandins mediate the endotoxin-induced suppression of pulsatile gonadotropin-releasing hormone and luteinizing hormone secretion in the ewe. Endocrinology 2000, 141:1050-1058.
13. Hart B.L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 1988, 12:123-137.
14. Hau M. Regulation of male traits by testosterone: implications for the evolution of vertebrate life histories. BioEssays 2007, 29:133-144.
15. He D., Sato I., Kimura F., Akema T. Lipopolysaccharide inhibits luteinizing hormone release through interaction with opioid and excitatory amino acid inputs to gonadotropin-releasing hormone neurones in female rats: possible evidence for a common mechanism involved in infection and immobilization stress. J. Neuroendocrinol. 2003, 15:559-563.
16. Herman A.P., Tomaszewska-Zaremba D. Effect of endotoxin on the expression of GnRH and GnRHR genes in the hypothalamus and anterior pituitary gland of anestrous ewes. Anim. Reprod. Sci. 2010, 120:105-111.
17. Iwasa T., Matsuzaki T., Murakami M., Shimizu F., Kuwahara A., Yasui T., Irahara M. Decreased expression of kisspeptin mediates acute immune/inflammatory stress-induced suppression of gonadotropin secretion in female rat. J. Endocrinol. Invest. 2008, 31:656-659.
18. Johnson M.A., Tsutsui K., Fraley G.S. Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat. Horm. Behav. 2007, 51:171-180.
19. Johnson R.W., Curtis S.E., Dantzer R., Bahr J.M., Kelley K.W. Sickness behavior in birds caused by peripheral or central injection of endotoxin. Physiol. Behav. 1993, 53:343-348.
20. Kriegsfeld L.J., Gibson E.M., Williams W.P., Zhao S., Mason A.O., Bentley G.E., Tsutsui K. The roles of RFamide-related peptide-3 in mammalian reproductive function and behaviour. J. Neuroendocrinol. 2010, 22:692-700.
21. Nappi R.E., Rivest S. Effect of immune and metabolic challenges on the luteinizing hormone-releasing hormone neuronal system in cycling female rats: an evaluation at the transcriptional level. Endocrinology 1997, 138:1374-1384.
22. Owen-Ashley N.T., Turner M., Hahn T.P., Wingfield J.C. Hormonal, behavioral, and thermoregulatory responses to bacterial lipopolysaccharide in captive and free-living white-crowned sparrows (Zonotrichia leucophrys gambelii). Horm. Behav. 2006, 49:15-29.
23. Owen-Ashley N.T., Wingfield J.C. Seasonal modulation of sickness behavior in free-living northwestern song sparrows (Melospiza melodia morphna). J. Exp. Biol. 2006, 209:3062-3070.
24. Perfito N., Zann R., Ubuka T., Bentley G., Hau M. Potential roles for GNIH and GNRH-II in reproductive axis regulation of an opportunistically breeding songbird. Gen. Comp. Endocrinol. 2011, 173:20-26.
25. Qi Y., Oldfield B.J., Clarke I.J. Projections of RFamide-related peptide-3 neurones in the ovine hypothalamus, with special reference to regions regulating energy balance and reproduction. J. Neuroendocrinol. 2009, 21:690-697.
26. Refojo D., Arias P., Moguilevsky J.A., Feleder C. Effect of bacterial endotoxin on in vivo pulsatile gonadotropin secretion in adult male rats. Neuroendocrinology 1998, 67:275-281.
27. Rivest S., Rivier C. Centrally injected interleukin-1-beta inhibits the hypothalamic lhrh secretion and circulating lh levels via prostaglandins in rats. J. Neuroendocrinol. 1993, 5:445-450.
28. Rivest S., Rivier C. The role of corticotropin-releasing factor and interleukin-i in the regulation of neurons controlling reproductive functions. Endocr. Rev. 1995, 16:177-199.
29. Rivier C. Role of endotoxin and interleukin-1 in modulating ACTH, LH and sex steroid secretion. Adv. Exp. Med. Biol. 1990, 274:295-301.
30. Schlafer D.H., Yuh B., Foley G.L., Elssaser T.H., Sadowsky D., Nathanielsz P.W. Effect of salmonella endotoxin administered to the pregnant sheep at 133-142days gestation on fetal oxygenation, maternal and fetal adrenocorticotropic hormone and cortisol, and maternal plasma tumor-necrosis-factor-alpha concentrations. Biol. Reprod. 1994, 50:1297-1302.
31. Tachibana T., Sato M., Takahashi H., Ukena K., Tsutsui K., Furuse M. Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks. Brain Res. 2005, 1050:94-100.
32. Tomaszewska-Zaremba D., Herman A. The role of immunological system in the regulation of gonadoliberin and gonadotropin secretion. Reprod. Biol. 2009, 9:11-23.
33. Tsutsui K., Ubuka T., Bentley G.E., Kriegsfeld L.J. Gonadotropin-inhibitory hormone (GnIH): discovery, progress and prospect. Gen. Comp. Endocrinol. 2012, 10.1016/j.ygcen.2012.02.013.
34. Watanobe H., Hayakawa Y. Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats. Endocrinology 2003, 144:4868-4875.
35. Williams C.Y., Harris T.G., Battaglia D.F., Viguie C., Karsch F.J. Endotoxin inhibits pituitary responsiveness to gonadotropin-releasing hormone. Endocrinology 2001, 142:1915-1922.
36. Wingfield J.C., Hegner R.E., Dufy A.M., Ball G.F. The "challenge hypothesis": theoretical implications for patterns of testosterone secretion, mating systems, and breeding strategies. Am. Nat. 1990, 136:829-846.
37. Wingfield J.C., Hegner R.E., Lewis D.M. Circulating levels of luteinizing-hormone and steroid-hormones in relation to social-status in the cooperatively breeding white-browed sparrow weaver, Plocepasser mahali. J. Zool. 1991, 225:43-58.
38. Wingfield J.C., Vleck C.M., Moore M.C. Seasonal changes of the adrenocortical response to stress in birds of the Sonoran Desert. J. Exp. Zool. 1992, 264:419-428.
39. Xiao E., Xia-Zhang L., Ferin M. Inhibitory effects of endotoxin on LH secretion in the ovariectomized monkey are prevented by naloxone but not by an interleukin-1 receptor antagonist. Neuroimmunomodulation 2000, 7:6-15.
40. Yirmiya R., Avitsur R., Donchin O., Cohen E. Interleukin-1 inhibits sexual-behavior in female but not in male-rats. Brain Behav. Immun. 1995, 9:220-233.
41. Zhao S., Fernald R.D. Comprehensive algorithm for quantitative real-time polymerase chain reaction. J. Comput. Biol. 2005, 12:1047-1064.