CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion

Cellular and Molecular Life Sciences

Volumn 69, Issue 16, 2012, Pages 2751-2764

  Moiseeva, Elena P ^a   Leyland, Mark L ^a   Bradding, Peter ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Adhesion molecules; Allergy; Apoptosis; Human; Lung; Mast cells; Signal transduction

Indexed keywords

BETA2 INTEGRIN; CASPASE 3; CASPASE 7; CELL ADHESION MOLECULE; CELL ADHESION MOLECULE 1; COMPLEMENTARY DNA; MESSENGER RNA; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; STEM CELL FACTOR; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP4; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ARTICLE; CELL ADHESION; CELL AGGREGATION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EXON; HUMAN; HUMAN CELL; MAST CELL; MASTOCYTOSIS; PROTEIN EXPRESSION; STOP CODON;

BLOTTING, WESTERN; CELL ADHESION; CELL ADHESION MOLECULES; CELL AGGREGATION; CELL SURVIVAL; CELLS, CULTURED; HUMANS; IMMUNOGLOBULINS; LEUKEMIA, MAST-CELL; LUNG; MAST CELLS; MAST-CELL SARCOMA; PROTEIN ISOFORMS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84864290344     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-0948-y     Document Type: Article

References (50)

1. Galli SJ, Tsai M (2010) Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity. Eur J Immunol 40:1843-1851
2. Moiseeva EP, Bradding P (2011) Mast cells in lung inflammation. Adv Exp Med Biol 716:235-269
3. Chiarugi P, Giannoni E (2008) Anoikis: a necessary death program for anchorage-dependent cells. Biochem Pharmacol 76:1352-1364
4. Yang W, Kaur D, Okayama Y, Ito A, Wardlaw AJ, Brightling CE, Bradding P (2006) Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol 176:1238-1243
5. Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P (2008) Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol 181:2772-2780
6. Ito A, Jippo T, Wakayama T, Morii E, Koma Y, Onda H, Nojima H, Iseki S, Kitamura Y (2003) SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF. Blood 101:2601-2608
7. Ito A, Koma Y, Watabe K, Jippo T, Wakayama T, Iseki S, Kitamura Y (2004) Contribution of the SgIGSF adhesion molecule to survival of cultured mast cells in vivo. Biochem Biophys Res Commun 319(1):200-206
8. Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F et al (1999) A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2. Genomics 62:139-146
9. Zhiling Y, Fujita E, Tanabe Y, Yamagata T, Momoi T, Momoi MY (2008) Mutations in the gene encoding CADM1 are associated with autism spectrum disorder. Biochem Biophys Res Commun 377:926-929
10. Hasstedt SJ, Bezemer ID, Callas PW, Vossen CY, Trotman W, Hebbel RP et al (2009) Cell adhesion molecule 1: a novel risk factor for venous thrombosis. Blood 114:3084-3091
11. Nowacki S, Skowron M, Oberthuer A, Fagin A, Voth H, Brors B et al (2008) Expression of the tumour suppressor gene CADM1 is associated with favourable outcome and inhibits cell survival in neuroblastoma. Oncogene 27:3329-3338
12. Uchino K, Ito A, Wakayama T, Koma Y, Okada T, Ohbayashi C et al (2003) Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung. Cancer 98:1002-1007
13. Ito T, Shimada Y, Hashimoto Y, Kaganoi J, Kan T, Watanabe G et al (2003) Involvement of TSLC1 in progression of esophageal squamous cell carcinoma. Cancer Res 63:6320-6326
14. Sasaki H, Nishikata I, Shiraga T, Akamatsu E, Fukami T, Hidaka T et al (2005) Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. Blood 105:1204-1213
15. Dewan MZ, Takamatsu N, Hidaka T, Hatakeyama K, Nakahata S, Fujisawa J et al (2008) Critical role for TSLC1 expression in the growth and organ infiltration of adult T-cell leukemia cells in vivo. J Virol 82:11958-11963
16. Kuramochi M, Fukuhara H, Nobukuni T, Kanbe T, Maruyama T, Ghosh HP et al (2001) TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet 27:427-430
17. Flicek P, Amode MR, Barrell D, Beal K, Brent S, Chen Y et al (2011) Ensembl 2011. Nucleic Acids Res 39:D800-D806
18. Sayers EW, Barrett T, Benson DA, Bolton E, Bryant SH, Canese K et al (2011) Database resources of the national center for biotechnology information. Nucleic Acids Res 39:D38-D51
19. Biederer T (2006) Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules. Genomics 87:139-150
20. Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R et al (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Nat Biotechnol 27:378-386
21. Fogel AI, Akins MR, Krupp AJ, Stagi M, Stein V, Biederer T (2007) SynCAMs organize synapses through heterophilic adhesion. J Neurosci 27:12516-12530
22. Koma Y, Ito A, Wakayama T, Watabe K, Okada M, Tsubota N et al (2004) Cloning of a soluble isoform of the SgIGSF adhesion molecule that binds the extracellular domain of the membranebound isoform. Oncogene 23:5687-5692
23. Xing W, Austen KF, Gurish MF, Jones TG (2011) Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue. Proc Natl Acad Sci USA 108:14210-14215
24. Bischoff SC (2007) Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol 7:93-104
25. Butterfield JH, Weiler D, Dewald G, Gleich GJ (1988) Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk Res 12:345-355
26. Kirshenbaum AS, Akin C, Wu Y, Rottem M, Goff JP, Beaven MA et al (2003) Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FceRI or FccRI. Leuk Res 27:677-682
27. Sanmugalingam D, Wardlaw AJ, Bradding P (2000) Adhesion of human lungmast cells to bronchial epithelium: evidence for a novel carbohydrate-mediated mechanism. J Leukoc Biol 68:38-46
28. Moiseeva EP, Almeida GM, Jones GD, Manson MM (2007) Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. Mol Cancer Ther 6:3071-3079
29. Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3:1101-1108
30. Wykes RC, Lee M, Duffy SM, Yang W, Seward EP, Bradding P (2007) Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival. J Immunol 179:4045-4052
31. Weber S, Babina M, Feller G, Henz BM (1997) Human leukaemic (HMC-1) and normal skin mast cells express beta 2-integrins: characterization of beta 2-integrins and ICAM-1 on HMC-1 cells. Scand J Immunol 45:471-481
32. Toru H, Kinashi T, Ra C, Nonoyama S, Yata J, Nakahata T (1997) Interleukin-4 induces homotypic aggregation of human mast cells by promoting LFA-1/ICAM-1 adhesion molecules. Blood 89:3296-3302
33. Tegoshi T, Nishida M, Ishiwata K, Kobayashi T, Uchiyama F, Nabeshima K et al (2000) E-cadherin and cadherin-associated cytoplasmic proteins are expressed in murine mast cells. Lab Invest 80:1571-1581
34. Nishida M, Kawai K, Tanaka M, Tegoshi T, Arizono N (2003) Expression of E-cadherin in human mast cell line HMC-1. APMIS 111:1067-1074
35. Aichberger KJ, Mayerhofer M, Gleixner KV, Krauth MT, Gruze A, Pickl WF et al (2007) Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412. Blood 109:3031-3041
36. Lilla JN, Chen CC, Mukai K, Benbarak MJ, Franco CB, Kalesnikoff J et al (2011) Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice. Blood 118:6930-6938
37. Aichberger KJ, Gleixner KV, Mirkina I, Cerny-Reiterer S, Peter B, Ferenc V et al (2009) Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs. Blood 114:5342-5351
38. Thomas LW, Lam C, Edwards SW (2010) Mcl-1; the molecular regulation of protein function. FEBS Lett 584:2981-2989
39. Akgul C, Moulding DA, Edwards SW (2004) Alternative splicing of Bcl-2-related genes: functional consequences and potential therapeutic applications. Cell Mol Life Sci 61:2189-2199
40. Kim JH, Sim SH, Ha HJ, Ko JJ, Lee K, Bae J (2009) MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death. FEBS Lett 583:2758-2764
41. Julenius K, Molgaard A, Gupta R, Brunak S (2005) Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites. Glycobiology 15:153-164
42. North SJ, von Gunten S, Antonopoulos A, Trollope A, Macglashan DW Jr, Jang-Lee J et al (2011) Glycomic analysis of human mast cells, eosinophils and basophils. Glycobiology 22:12-22
43. Horny HP (2009) Mastocytosis: an unusual clonal disorder of bone marrow-derived hematopoietic progenitor cells. Am J Clin Pathol 132:438-447
44. Mayerhofer M, Gleixner KV, Hoelbl A, Florian S, Hoermann G, Aichberger KJ et al (2008) Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens. J Immunol 180:5466-5476
45. Youle RJ, Strasser A (2008) The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9:47-59
46. Drexler HG, MacLeod RA (2003) Malignant hematopoietic cell lines: in vitro models for the study of mast cell leukemia. Leuk Res 27(8):671-676
47. Tanabe Y, Kasahara T, Momoi T, Fujita E (2008) Neuronal RA175/SynCAM1 isoforms are processed by tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM17-like proteases. Neurosci Lett 444:16-21
48. Cavallaro U, Dejana E (2011) Adhesion molecule signalling: not always a sticky business. Nat Rev Mol Cell Biol 12:189-197
49. Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K et al (2010) CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. J Biol Chem 285:15511-15522
50. Kawano S, Ikeda W, Kishimoto M, Ogita H, Takai Y (2009) Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2. J Biol Chem 284:23793-23805