Repeat-dose sirolimus pharmacokinetics and pharmacodynamics in patients with hepatic allografts

European Journal of Clinical Pharmacology

Volumn 68, Issue 5, 2012, Pages 589-597

  Reichen, Jürg ^a   Stickel, Felix ^a   Bhattacharya, Indranil ^b   Matschke, Kyle ^b   Maller, Eric ^b   Korth Bradley, Joan ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b PFIZER INC   (United States)

Author keywords

Hepatic allograft; Hepatic insufficiency; Pharmacodynamics; Pharmacokinetics; Sirolimus

Indexed keywords

AZATHIOPRINE; CALCINEURIN INHIBITOR; CYCLOSPORIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DEATH; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; FEMALE; GRAFT RECIPIENT; HUMAN; HUMAN CELL; LIVER GRAFT REJECTION; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; OPEN STUDY; PHARMACODYNAMICS; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPEATED DRUG DOSE; SINGLE DRUG DOSE; STEADY STATE; STOMATITIS; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADULT; FEMALE; GRAFT REJECTION; HEPATIC INSUFFICIENCY; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INCIDENCE; LIVER; LIVER TRANSPLANTATION; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; PNEUMONIA; RISK; SEVERITY OF ILLNESS INDEX; SIROLIMUS; STOMATITIS; TRANSPLANTATION, HOMOLOGOUS;

EID: 84864286114     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-011-1172-7     Document Type: Article

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