Hydroquinone-induced apoptosis of human lymphocytes through caspase 9/3 pathway

Molecular Biology Reports

Volumn 39, Issue 6, 2012, Pages 6737-6743

  Lee, Ji Sook ^a   Yang, Eun Ju ^b   Kim, In Sik ^c  

^a Wonkwang Health Science University   (South Korea)

^b Daegu Haany University   (South Korea)

^c Eulji University   (South Korea)

Author keywords

Apoptosis; Cytokine; Cytotoxicity; Hydroquinone; Lymphocyte

Indexed keywords

BENZENE; CASPASE 3; CASPASE 9; FORMALDEHYDE; HYDROQUINONE; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; ORTHO XYLENE; PARA XYLENE; PHENOL; PROCASPASE 3; PROCASPASE 9; REACTIVE OXYGEN METABOLITE; TOLUENE;

APOPTOSIS; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN CLEAVAGE; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

APOPTOSIS; BENZENE; CASPASE 3; CASPASE 9; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOKINES; CYTOTOXINS; ENZYME ACTIVATION; HUMANS; HYDROQUINONES; LYMPHOCYTES; PHENOL; REACTIVE OXYGEN SPECIES;

EID: 84864281834     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1498-y     Document Type: Article

References (20)

1. Schrenk D, Orzechowski A, Snyder R, Burchell B, Ingelman-Sundberg M, Bock KW (1996) Phase II metabolism of benzene. Environ Health Perspect 104:1183-1188 (Pubitemid 27046146)
2. Ross D (2000) The role of metabolism and specific metabolites in benzene-induced toxicity: evidence and issues. J Toxicol Environ Health A 61:357-372
3. Ji Z, Zhang L, Peng V, Ren X, McHale CM, Smith MT (2010) A comparison of the cytogenetic alterations and global DNA hy-pomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide. Leukemia 24:986-991
4. Hazel BA, Baum C, Kalf GF (1996) Hydroquinone, a bioreactive metabolite of benzene, inhibits apoptosis in myeloblast. Stem Cells 14:730-742 (Pubitemid 26404624)
5. Hazel BA, Kalf GF (1996) Induction of granulocytic differentiation in myeloblast by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor. Recept Signal Transduct 6:1-12
6. Yang EJ, Lee JS, Yun CY, Kim IS (2011) The pro-apoptotic effect of hydroquinone in human neutrophils and eosinophils. Toxicol In Vitro 25:131-137
7. Pons M, Marin-Castaño ME (2011) Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo. PLoS One 6:e16722
8. Otsuki T, Hayashi H, Nishimura Y, Hyodo F, Maeda M, Kumagai N, Miura Y, Kusaka M, Uragami K (2011) Dysregulation of autoimmunity caused by silica exposure and alteration of Fasmediated apoptosis in T lymphocytes derived from silicosis patients. Int J Immunopathol Pharmacol 24:11S-16S
9. Shen Y, Luo Q, Xu H, Gong F, Zhou X, Sun Y, Wu X, Liu W, Zeng G, Tan N, Xu Q (2011) Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclo-peptide, for preventing murine experimental colitis. Biochem Pharmacol 82:260-268
10. Li Q, Geiselhart L, Mittler JN, Mudzinski SP, Lawrence DA, Freed BM (1996) Inhibition of human lymphoblast proliferation by hydroquinone. Toxicol Appl Pharmacol 139:317-323 (Pubitemid 26281608)
11. McCue JM, Link KL, Eaton SS, Freed BM (2000) Exposure to cigarette tar inhibits ribonucleotide reductase and blocks lymphocyte proliferation. J Immunol 165:6771-6775 (Pubitemid 32001142)
12. Poirier M, Fournier M, Brousseau P, Morin A (2002) Effects of volatile aromatics, aldehydes, and phenols in tobacco smoke on viability and proliferation of mouse lymphocytes. J Toxicol Environ Health A 65:1437-1451
13. Kim YJ, Woo HD, Kim BM, Lee YJ, Kang SJ, Cho YH, Chung HW (2009) Risk assessment of hydroquinone: differential responses of cell growth and lethality correlated to hydroquinone concentration. J Toxicol Environ Health A 72:1272-1278
14. Ishihama M, Toyooka T, Ibuki Y (2008) Generation of phos-phorylated histone H2AX by benzene meteabolites. Toxicol In Vitro 22:1861-1868
15. Rubio V, Zhang J, Valverde M, Rojas E, Shi ZZ (2011) Essential role of Nrf2 in protection against hydroquinone-and benzoqui-none-induced cytotoxicity. Toxicol In Vitro 25:521-529
16. Kerzic PJ, Pyatt DW, Zheng JH, Gross SA, Le A, Irons RD (2003) Inhibition of NF-kappaB by hydroquinone sensitizes human bone marrow progenitor cells to TNF-alpha-induced apoptosis. Toxicology 187:127-137 (Pubitemid 36423308)
17. Terasaka H, Kadoma Y, Sakagami H, Fujisawa S (2005) Cyto-toxicity and apoptosis-inducing activity of bisphenol A and hydroquinone in HL-60 cells. Anticancer Res 25:2241-2247 (Pubitemid 40904629)
18. Zhang F, Lau SS, Monks TJ (2011) The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis. Toxicol Sci 120:87-97
19. Lau SS, Kuhlman CL, Bratton SB, Monks TJ (2010) Role of hydroquinone-thiol conjugates in benzene-mediated toxicity. Chem Biol Interact 184:212-217
20. Yadav A, Saini V, Arora S (2010) MCP-1: chemoattractant with a role beyond immunity: a review. Clin Chim Acta 411:1570-1579