Epidermal growth factor receptor mediates injury in rapidly progressive glomerular disease

International Urology and Nephrology

Volumn 44, Issue 3, 2012, Pages 971-975

  Brandt, Sabine ^a   Mertens, Peter R ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXOID CRM197; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ARTICLE; AUTOCRINE EFFECT; AUTOIMMUNE DISEASE; DISEASE ACTIVITY; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; HUMAN; IMMUNOPATHOGENESIS; KIDNEY INJURY; LUNG NON SMALL CELL CANCER; NONHUMAN; OVARY CANCER; PANCREAS CANCER; PODOCYTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN URINE LEVEL; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS;

ANIMALS; GLOMERULONEPHRITIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY GLOMERULUS; PODOCYTES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 84864281606     PISSN: 03011623     EISSN: 15732584     Source Type: Journal    
DOI: 10.1007/s11255-012-0159-3     Document Type: Article

References (29)

1. Bollee G, Flamant M, Schordan S et al (2011) Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med 17:1242-1250
2. Bach D, Hauser K, Grabensee B (1996) Long-term clinical course in acute crescentic glomerulonephritis. Int Urol Nephrol 28:439-453 (Pubitemid 26325268)
3. Kain R, Exner M, Brandes R et al (2008) Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat Med 14:1088-1096
4. Yarden Y, Sliwkowski MX (2001) Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2:127-137 (Pubitemid 33674041)
5. Citri A, Yarden Y (2006) EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 7:505-516 (Pubitemid 44036456)
6. Schlessinger J (2002) Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110: 669-672 (Pubitemid 35283957)
7. Zeng F, Singh AB, Harris RC (2009) The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology. Exp Cell Res 315: 602-610
8. Holbro T, Civenni G, Hynes NE (2003) The ErbB receptors and their role in cancer progression. Exp Cell Res 284: 99-110 (Pubitemid 36331969)
9. Avraham R, Yarden Y (2011) Feedback regulation of EGFR signalling: decision making by early and delayed loops. Nat Rev Mol Cell Biol 12:104-117
10. Harris R (2011) EGFR signaling in podocytes at the root of glomerular disease. Nat Med 17:1188-1189
11. Tada H, Sasada R, Kawaguchi Y et al (1999) Processing and juxtacrine activity of membrane-anchored betacellulin. J Cell Biochem 72:423-434 (Pubitemid 29047404)
12. Inui S, Higashiyama S, Hashimoto K et al (1997) Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth. J Cell Physiol 171:291-298 (Pubitemid 27235148)
13. Anklesaria P, Teixido J, Laiho M et al (1990) Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation. Proc Natl Acad Sci USA 87:3289-3293
14. Iwamoto R, Mekada E (2000) Heparin-binding EGF-like growth factor: a juxtacrine growth factor. Cytokine Growth Factor Rev 11:335-344
15. Singh AB, Sugimoto K, Dhawan P et al (2007) Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance. Am J Physiol Cell Physiol 293:C1660-C1668 (Pubitemid 350085633)
16. Sakai M, Zhang M, Homma T et al (1997) Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. J Clin Invest 99:2128-2138 (Pubitemid 27203769)
17. Yoshizumi M, Kourembanas S, Temizer DH et al (1992) Tumor necrosis factor increases transcription of the heparinbinding epidermal growth factor-like growth factor gene in vascular endothelial cells. J Biol Chem 267:9467-9469
18. Kume N, GimbroneMA Jr (1994) Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells. J Clin Invest 93:907-911 (Pubitemid 24072836)
19. Marikovsky M, Breuing K, Liu PY et al (1993) Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury. Proc Natl Acad Sci USA 90:3889-3893 (Pubitemid 23134131)
20. Higashiyama S, Abraham JA, Miller J et al (1991) A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251:936-939 (Pubitemid 21926188)
21. Blotnick S, Peoples GE, Freeman MR et al (1994) T lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: differential production and release by CD4? and CD8? T cells. Proc Natl Acad Sci USA 91:2890-2894
22. Feng L, Garcia GE, Yang Y et al (2000) Heparin-binding EGF-like growth factor contributes to reduced glomerular filtration rate during glomerulonephritis in rats. J Clin Invest 105:341-350 (Pubitemid 30094454)
23. Khong TF, Fraser S, Katerelos M et al (2000) Inhibition of heparin-binding epidermal growth factor-like growth factor increases albuminuria in puromycin aminonucleoside nephrosis. Kidney Int 58:1098-1107
24. Polihronis M, Murphy BF, Pearse MJ et al (1996) Heparinbinding epidermal growth factor-like growth factor, an immediate-early gene for mesangial cells, is up-regulated in the Thy-1.1 model. Exp Nephrol 4:271-278 (Pubitemid 26342896)
25. Triantafyllopoulou A, Franzke CW, Seshan SV et al (2010) Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc Natl Acad Sci USA 107:3012-3017
26. Mitamura T, Higashiyama S, Taniguchi N et al (1995) Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. J Biol Chem 270:1015-1019
27. Kunami N, Yotsumoto F, Ishitsuka K et al (2011) Antitumor effects of CRM197, a specific inhibitor of HB-EGF, in T-cell acute lymphoblastic leukemia. Anticancer Res 31:2483-2488
28. Miyamoto S, Yagi H, Yotsumoto F et al (2006) Heparinbinding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy. Cancer Sci 97:341-347
29. Hamaoka M, Chinen I, Murata T et al (2010) Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding. J Biochem 148:55-69