Increased seroprevalence of HBV DNA with mutations in the S gene among individuals greater than 18 years old after complete vaccination

Gastroenterology

Volumn 143, Issue 2, 2012, Pages 400-407

  Lai, Ming Wei ^a,c   Lin, Tzou Yien ^a,c   Tsao, Kuo Chien ^a,b   Huang, Chung Guei ^a,b   Hsiao, Mei Jen ^a,b   Liang, Kung Hao ^a   Yeh, Chau Ting ^a,c  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Immune Escape; Immunization; Resistance Mechanisms; Viremia

Indexed keywords

HEPATITIS B CORE ANTIBODY; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; HEPATITIS B VIRUS DNA; UNCLASSIFIED DRUG; VIRUS DNA;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; BLOOD SAMPLING; CHILD; FEMALE; GENE MUTATION; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; INFANT; INFECTION PREVENTION; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SEQUENCE ANALYSIS; SEROPREVALENCE; TAIWAN; VACCINATION;

EID: 84864278758     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.05.002     Document Type: Article

References (66)

1. World Health Organization Hepatitis B World Health Organization Fact Sheets 204 (revised August 2008) www.who.int/mediacentre/factsheets/fs204/en/ Assessed October 10, 2011
2. A. Lok, B. McMahon Chronic hepatitis B Hepatology 45 2007 507 539 (Pubitemid 46374607)
3. K.C. Hyams Risks of chronicity following acute hepatitis B virus infection: a review Clin Infect Dis 20 1995 992 1000
4. R. Beasley, L.Y. Hwang, C.C. Lin Incidence of hepatitis B virus infections in preschool children in Taiwan J Infect Dis 146 1982 198
5. L. Gray Davis, D. Weber, S. Lemon Horizontal transmission of hepatitis B virus Lancet 333 1989 889 893 (Pubitemid 19107886)
6. C.E. Stevens, R.P. Beasley, J. Tsui Vertical transmission of hepatitis B antigen in Taiwan N Engl J Med 292 1975 771 774
7. D.S. Chen, N.H.M. Hsu, J.L. Sung A mass vaccination program in Taiwan against hepatitis B virus infection in infants of hepatitis B surface antigen-carrier mothers JAMA 257 1987 2597 2603
8. Y.J. Tsen, M.H. Chang, H.Y. Hsu Seroprevalence of hepatitis B virus infection in children in Taipei, 1989: five years after a mass hepatitis B vaccination program J Med Virol 34 1991 96 99
9. H.L. Chen, M.H. Chang, Y.H. Ni Seroepidemiology of hepatitis B virus infection in children: ten years of mass vaccination in Taiwan JAMA 276 1996 906 908
10. Y.H. Ni, M.H. Chang, L.M. Huang Hepatitis B virus infection in children and adolescents in a hyperendemic area: 15 years after mass hepatitis B vaccination Ann Intern Med 135 2001 796 800
11. Y.H. Ni, L.M. Huang, M.H. Chang Two decades of universal hepatitis B vaccination in Taiwan: impact and implication for future strategies Gastroenterology 132 2007 1287 1293
12. M.H. Chang, C.J. Chen, M.S. Lai Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children N Engl J Med 336 1997 1855 1859
13. M.H. Chang, S.L. You, C.J. Chen Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study J Natl Cancer Inst 101 2009 1348 1355
14. H.L. Chen, C.J. Chang, M.S. Kong Pediatric fulminant hepatic failure in endemic areas of hepatitis B infection: 15 years after universal hepatitis B vaccination Hepatology 39 2004 58 63
15. World Health Organization: vaccines and biologicals: WHO vaccine preventable disease monitoring system: global summary 2009 data up to 2008) www.who.int/immunization/documents/WHO-IVB-2009/en/index.html Assessed October 10, 2011
16. M.A.B.vd Sande, P. Waight, M. Mendy Long-term protection against carriage of hepatitis B virus after infant vaccination J Infect Dis 193 2006 1528 1535 (Pubitemid 43794582)
17. B.J. McMahon, D.L. Bruden, K.M. Petersen Antibody levels and protection after hepatitis B vaccination: results of a 15-year follow-up Ann Intern Med 142 2005 333 341 (Pubitemid 40293406)
18. M.H. Chang Breakthrough HBV infection in vaccinated children in Taiwan: surveillance for HBV mutants Antivir Ther 15 2010 463 469
19. S.L. Ngui, N.J. Andrews, G.S. Underhill Failed postnatal immunoprophylaxis for hepatitis B: characteristics of maternal hepatitis B virus as risk factors Clin Infect Dis 27 1998 100 106 (Pubitemid 28334427)
20. R. del Canho, P.M. Grosheide, S.W. Schalm Failure of neonatal hepatitis B vaccination: the role of HBV-DNA levels in hepatitis B carrier mothers and HLA antigens in neonates J Hepatol 20 1994 483 486 (Pubitemid 24146362)
21. H.Y. Hsu, M.H. Chang, Y.H. Ni Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis Hepatology 26 1997 786 791
22. H.Y. Hsu, M.H. Chang, S.H. Liaw Changes of hepatitis B surface antigen variants in carrier children before and after universal vaccination in Taiwan Hepatology 30 1999 1312 1317
23. H.Y. Hsu, M.H. Chang, Y.H. Ni Survey of hepatitis B surface variant infection in children 15 years after a nationwide vaccination programme in Taiwan Gut 53 2004 1499 1503
24. W.F. Carman, A.R. Zanetti, P. Karayiannis Vaccine-induced escape mutant of hepatitis B virus Lancet 336 1990 325 329 (Pubitemid 20264145)
25. McMahon G, McCarthy L, Dottavio D, et al. Surface antigen and polymerase gene variations in a hepatitis B virus isolate from a monoclonal antibody treated liver transplant patient. Abstract 82. Presented at: International Symposium on Viral Hepatitis and Liver Disease; 1990; Houston, TX.
26. O.C. Jin, C.W. Ning, K. Shiuan Identification of hepatitis B surface antigen variants with alterations outside the "a" determinant in immunized Singapore infants J Infect Dis 179 1999 259 263 (Pubitemid 29028367)
27. M.S. Ho, C.F. Lu, J. Kuo A family cluster of an immune escape variant of hepatitis B virus infecting a mother and her two fully immunized children Clin Diagn Lab Immun 2 1995 760 762
28. C.J. Oon, W.N. Chen, K.S. Goo Intra-familial evidence of horizontal transmission of hepatitis B virus surface antigen mutant G145R J Infect 41 2000 260 264 (Pubitemid 32051047)
29. C.J. Liu, S.C. Lo, J.H. Kao Transmission of occult hepatitis B virus by transfusion to adult and pediatric recipients in Taiwan J Hepatol 44 2006 39 46
30. J.N. Wilson, D.J. Nokes, W.F. Carman Current status of HBV vaccine escape variants - a mathematical model of their epidemiology J Viral Hepat 5 1998 25 30
31. H.Y. Hsu, M.H. Chang, Y.H. Ni No increase in prevalence of hepatitis B surface antigen mutant in a population of children and adolescents who were fully covered by universal infant immunization J Infect Dis 201 2010 1192 1200
32. C.T. Yeh, R.N. Chien, C.M. Chu Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy Hepatology 31 2000 1318 1326
33. C.J. Chen, L.Y. Wang, M.W. Yu Epidemiology of hepatitis B virus infection in the Asia-Pacific region J Gastroenterol Hepatol 15 2000 E3 E6
34. A.A. Basuni, L. Butterworth, G. Cooksley Prevalence of HBsAg mutants and impact of hepatitis B infant immunisation in four Pacific Island countries Vaccine 22 2004 2791 2799 (Pubitemid 38900656)
35. D. FitzSimons, G. Francois, A. Hall Long-term efficacy of hepatitis B vaccine, booster policy, and impact of hepatitis B virus mutants Vaccine 23 2005 4158 4166 (Pubitemid 40814591)
36. S. Viviani, A. Jack, A. Hall Hepatitis B vaccination in infancy in The Gambia: protection: against carriage at 9 years of age Vaccine 17 1999 2946 2950 (Pubitemid 29366973)
37. H.-M. Hsu, D.-S. Chen, C.-H. Chuang Efficacy of a mass hepatitis B vaccination program in Taiwan JAMA 260 1988 2231 2235
38. European Consensus Group on Hepatitis B Immunity Are booster immunisations needed for lifelong hepatitis B immunity? Lancet 355 2000 561 565
39. J.T. Kao, J.H. Wang, C.H. Hung Long-term efficacy of plasma-derived and recombinant hepatitis B vaccines in a rural township of Central Taiwan Vaccine 27 2009 1858 1862
40. H.H. Shih, M.H. Chang, H.Y. Hsu Long term immune response of universal hepatitis B vaccination in infancy: a community-based study in Taiwan Pediatr Infect Dis J 18 1999 427 432
41. A.R. Zanetti, A. Mariano, L. Romanò Long-term immunogenicity of hepatitis B vaccination and policy for booster: an Italian multicentre study Lancet 366 2005 1379 1384 (Pubitemid 41443405)
42. Y. Poovorawan, V. Chongsrisawat, A. Theamboonlers Persistence of antibodies and immune memory to hepatitis B vaccine 20 years after infant vaccination in Thailand Vaccine 28 2010 730 736
43. C.Y. Lu, B.L. Chiang, W.K. Chi Waning immunity to plasma-derived hepatitis B vaccine and the need for boosters 15 years after neonatal vaccination Hepatology 40 2004 1415 1420
44. T. Samandari, A.E. Fiore, S. Negus Waning immunity to plasma-derived hepatitis B vaccine and the need for boosters 15 years after neonatal vaccination Pediatrics 120 2007 e373 e381
45. C.Y. Lu, Y.H. Ni, B.L. Chiang Humoral and cellular immune responses to a hepatitis B vaccine booster 15-18 years after neonatal immunization J Infect Dis 197 2008 1419 1426
46. C.F. Jan, K.C. Huang, Y.C. Chien Determination of immune memory to hepatitis B vaccination through early booster response in college students Hepatology 51 2010 1547 1554
47. M.W. Lai, C.S.H. Yeh, C.T. Yeh Infection with hepatitis B virus carrying novel pre-S/S gene mutations in female siblings vaccinated at birth: two case reports J Med Case Reports 4 2010 190 194
48. R. Heijtink, P. Van Bergen, M. Van Roosmalen Anti-HBs after hepatitis B immunization with plasma-derived and recombinant DNA-derived vaccines: binding to mutant HBsAg Vaccine 19 2001 3671 3680 (Pubitemid 32522765)
49. T. Bauer, K. Weinberger, W. Jilg Variants of two major T cell epitopes within the hepatitis B surface antigen are not recognized by specific T helper cells of vaccinated individuals Hepatology 35 2002 455 465 (Pubitemid 34106389)
50. W.N. Chen, C.J. Oon Hepatitis B virus surface antigen (HBsAg) mutants in Singapore adults and vaccinated children with high anti-hepatitis B virus antibody levels but negative for HBsAg J Clin Microbiol 38 2000 2793 2794
51. J. Torresi, L. Earnest-Silveira, G. Deliyannis Reduced antigenicity of the hepatitis B virus HBsAg protein arising as a consequence of sequence changes in the overlapping polymerase gene that are selected by lamivudine therapy Virology 293 2002 305 313
52. S. Datta, A. Banerjee, P.K. Chandra Genotype, phylogenetic analysis, and transmission pattern of occult hepatitis B virus (HBV) infection in families of asymptomatic HBsAg carriers J Med Virol 78 2006 53 59 (Pubitemid 41783843)
53. J. Sheldon, B. Ramos, J. Garcia-Samaniego Selection of hepatitis B virus (HBV) vaccine escape mutants in HBV-infected and HBV/HIV-coinfected patients failing antiretroviral drugs with anti-HBV activity J Acq Immun Def Synd 46 2007 279 282 (Pubitemid 350287353)
54. V. Avettand-Fenoel, D. Thabut, C. Katlama Immune suppression as the etiology of failure to detect anti-HBc antibodies in patients with chronic hepatitis B virus infection J Clin Microbiol 44 2006 2250 2253 (Pubitemid 43902187)
55. S. Laperche, C. Guitton, W. Smilovici Blood donors infected with the hepatitis B virus but persistently lacking antibodies to the hepatitis B core antigen Vox Sang 80 2001 90 94 (Pubitemid 35345778)
56. F. Zoulim, X. Zhang, C. Pichoud Heterogeneity of hepatitis B virus (HBV) core gene in a patient with HBV-associated cirrhosis and serum negativity for anti-HBc J Hepatol 24 1996 155 160 (Pubitemid 26059115)
57. Y.M. Wang, W.C. Ng, S.K. Lo Detection of pre-S/S gene mutants in chronic hepatitis B carriers with concurrent hepatitis B surface antibody and hepatitis B surface antigen J Gastroenterol 34 1999 600 606 (Pubitemid 29500324)
58. O. Lada, Y. Benhamou, T. Poynard Coexistence of hepatitis B surface antigen (HBs Ag) and anti-HBs antibodies in chronic hepatitis B virus carriers: influence of "a" determinant variants J Virol 80 2006 2968 2975 (Pubitemid 43346392)
59. J. Torresi Hepatitis B antiviral resistance and vaccine escape: two sides of the same coin Antivir Ther 13 2008 337
60. S. Corden, A.L. Ballard, S. Ijaz HBV DNA levels and transmission of hepatitis B by health care workers J Clin Virol 27 2003 52 58 (Pubitemid 36519155)
61. T.H. Westhoff, F. Jochimsen, A. Schmittel Fatal hepatitis B virus reactivation by an escape mutant following rituximab therapy Blood 102 2003 1930 (Pubitemid 37022596)
62. I. Cacciola, T. Pollicino, G. Squadrito Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease N Engl J Med 341 1999 22 26 (Pubitemid 29293716)
63. R.J.C. Gilson, A.E. Hawkins, M.R. Beecham Interactions between HIV and hepatitis B virus in homosexual men: effects on the natural history of infection AIDS 11 1997 597 606 (Pubitemid 27135881)
64. J. Torresi The virological and clinical significance of mutations in the overlapping envelope and polymerase genes of hepatitis B virus J Clin Virol 25 2002 97 106 (Pubitemid 35287234)
65. L. Cooley, A. Ayres, A. Bartholomeusz Prevalence and characterization of lamivudine-resistant hepatitis B virus mutations in HIV-HBV co-infected individuals AIDS 17 2003 1649 1657 (Pubitemid 36957907)
66. R.D. Sloan, S. Ijaz, P.L. Moore Antiviral resistance mutations potentiate hepatitis B virus immune evasion through disruption of its surface antigen a determinant Antivir Ther 13 2008 439 447 (Pubitemid 352016737)