Reversal of acute coagulopathy during hypotensive resuscitation using small-volume 7.5% NaCl adenocaine and Mg2+ in the rat model of severe hemorrhagic shock

Critical Care Medicine

Volumn 40, Issue 8, 2012, Pages 2417-2422

  Letson, Hayley L ^a   Pecheniuk, Natalie M ^b   Mhango, Lebo P ^a   Dobson, Geoffrey P ^a  

^a Institute of Vascular Medicine   (Australia)

^b JAMES COOK UNIVERSITY   (Australia)

Author keywords

adenocaine; adenosine; coagulopathy; hemorrhagic; hypertonic saline; hypocoagulopathy; lidocaine; magnesium; military; prehospital; resuscitation; shock; small volume; trauma

Indexed keywords

LIDOCAINE; MAGNESIUM ION; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING TIME; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; HEART RATE; HEMODYNAMICS; HEMORRHAGIC SHOCK; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; RAT; RESUSCITATION; SYSTOLIC BLOOD PRESSURE;

ADENOSINE; ANIMALS; BLOOD COAGULATION DISORDERS; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; HEMODYNAMICS; LIDOCAINE; MAGNESIUM; MALE; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; RATS; RESUSCITATION; SHOCK, HEMORRHAGIC; SODIUM CHLORIDE;

EID: 84864253563     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31825334c3     Document Type: Article

References (34)

1. Champion HR: Combat fluid resuscitation: Introduction and overview of conferences. J Trauma 2003; 54(5 Suppl):S7-12.
2. Hess JR, Brohi K, Dutton RP, et al: The coagulopathy of trauma: A review of mechanisms. J Trauma 2008; 65:748-754.
3. Angele MK, Schneider CP, Chaudry IH: Bench-to-bedside review: Latest results in hemorrhagic shock. Crit Care 2008; 12:218.
4. Niles SE, McLaughlin DF, Perkins JG, et al: Increased mortality associated with the early coagulopathy of trauma in combat casualties. J Trauma 2008; 64:1459-1463.
5. Ganter MT, Pittet JF: New insights into acute coagulopathy in trauma patients. Best Pract Res Clin Anaesthesiol 2010; 24:15-25.
6. Brohi K: Trauma induced coagulopathy. J R Army Med Corps 2009; 155:320-322.
7. Simmons RL, Collins JA, Heisterkamp CA, et al: Coagulation disorders in combat casualties. I. Acute changes after wounding. II. Effects of massive transfusion. Post-resuscitative changes. Ann Surg 1969; 169:455-482.
8. Floccard B, Rugeri L, Faure A, et al: Early coagulopathy in trauma patients: An on-scene and hospital admission study. Injury 2012; 43:26-32.
9. Midwinter MJ, Woolley T: Resuscitation and coagulation in the severely injured trauma patient. Philos Trans R Soc Lond, B, Biol Sci 2011; 366:192-203.
10. Letson HL, Dobson GP: Ultra-small intravenous bolus of 7.5% NaCl/Mg+ with adenosine and lidocaine improves early resuscitation outcome in the rat after severe hemorrhagic shock in vivo. J Trauma 2011; 71:708-719.
11. Letson HL, Dobson GP: Unexpected 100% survival following 60% blood loss using small-volume 7.5% NaCl with adenocaine and Mg2+ in the rat model of extreme hemorrhagic shock. Shock 2011; 36:586-594.
12. Dobson GP: Membrane polarity: A target for myocardial protection and reduced inflammation in adult and pediatric cardiothoracic surgery. J Thorac Cardiovasc Surg 2010; 140:1213-1217.
13. Dobson GP: Organ arrest, protection and preservation: Natural hibernation to cardiac surgery. Comp Biochem Physiol B, Biochem Mol Biol 2004; 139:469-485. (Pubitemid 39488282)
14. Canyon SJ, Dobson GP: Protection against ventricular arrhythmias and cardiac death using adenosine and lidocaine during regional ischemia in the in vivo rat. Am J Physiol Heart Circ Physiol 2004; 287:H1286-H1295. (Pubitemid 39096678)
15. Canyon SJ, Dobson GP: The effect of an adenosine and lidocaine intravenous infusion on myocardial high-energy phosphates and pH during regional ischemia in the rat model in vivo. Can J Physiol Pharmacol 2006; 84:903-912. (Pubitemid 46132215)
16. Shi W, Jiang R, Dobson GP, et al: Thenon-depolarizing, normokalemic cardioplegia formulation adenosine-lidocaine (Adenocaine) exerts anti-neutrophil effects by synergistic actions of its components. Journal Thorac Cardiovasc Surg 2012; 143:1167-1175.
17. Broussas M, Cornillet-Lefèbvre P, Potron G, et al: Adenosine inhibits tissue factor expression by LPS-stimulated human monocytes: Involvement of the A3 adenosine receptor. Thromb Haemost 2002; 88:123-130. (Pubitemid 34752277)
18. Paul S, Feoktistov I, Hollister AS, et al: Adenosine inhibits the rise in intracellular calcium and platelet aggregation produced by thrombin: Evidence that both effects are coupled to adenylate cyclase. Mol Pharmacol 1990; 37:870-875. (Pubitemid 20219897)
19. Johnston-Cox HA, Yang D, Ravid K: Physiological implications of adenosine receptor-mediated platelet aggregation. J Cell Physiol 2011; 226:46-51.
20. Huang GS, Lin TC, Wang JY, et al: Lidocaine priming reduces ADP-induced P-selectin expression and platelet-leukocyte aggregation. Acta Anaesthesiol Taiwan 2009; 47:56-61.
21. Cooke ED, Bowcock SA, Lloyd MJ, et al: Intravenous lignocaine in prevention of deep venous thrombosis after elective hip surgery. Lancet 1977; 2:797-799. (Pubitemid 8193250)
22. Shechter M, Merz CN, Paul-Labrador M, et al: Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease. Am J Cardiol 1999; 84:152-156. (Pubitemid 29331330)
23. Ellis V, Scully M, Kakkar V: The effect of divalent metal cations on the inhibition of human coagulation factor Xa by plasma proteinase inhibitors. Biochim Biophys Acta 1983; 747:123-129.
24. Martini WZ, Cortez DS, Dubick MA, et al: Thrombelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs. J Trauma 2008; 65:535-543.
25. García-Manzano A, González-Llaven J, Lemini C, et al: Standardization of rat blood clotting tests with reagents used for humans. Proc West Pharmacol Soc 2001; 44:153-155. (Pubitemid 34087743)
26. Bickell WH, Wall MJJr, Pepe PE, et al: Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 1994; 331: 1105-1109. (Pubitemid 24321214)
27. Spinella PC, Holcomb JB: Resuscitation and transfusion principles for traumatic hemorrhagic shock. Blood Rev 2009; 23:231-240.
28. Blackbourne LH, Czarnik J, Mabry R, et al: Decreasing killed in action and died of wounds rates in combat wounded. J Traumsa 2010; 69 Suppl 1:S1-S4.
29. Shaz BH, Winkler AM, James AB, et al: Pathophysiology of early trauma-induced coagulopathy: Emerging evidence for hemodilution and coagulation factor depletion. J Trauma 2011; 70:1401-1407.
30. Rijken DC, Lijnen HR: New insights into the molecular mechanisms of the fibrinolytic system. JThrombHaemost 2009; 7:4-13.
31. Brohi K, Cohen MJ, Ganter MT, et al: Acute traumatic coagulopathy: Initiated by hypoperfusion: Modulated through the protein C pathway? Ann Surg 2007; 245:812-818. (Pubitemid 46684113)
32. Monroe DM, Hoffman M: What does it take to make the perfect clot? Arterioscler Thromb Vasc Biol 2006; 26:41-48. (Pubitemid 43732226)
33. Kasthuri RS, Glover SL, Boles J, et al: Tissue factor and tissue factor pathway inhibitor as key regulators of global hemostasis: Measurement of their levels in coagulation assays. Semin Thromb Hemost 2010; 36:764-771.
34. Tieu BH, Holcomb JB, Schreiber MA: Coagulopathy: Its pathophysiology and treatment in the injured patient. World J Surg 2007; 31:1055-1064. (Pubitemid 46716770)