Common genetic variants associated with Sudden cardiac death: The finscdgen study

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Lahtinen, Annukka M ^a   Noseworthy, Peter A ^b,c   Havulinna, Aki S ^d   Jula, Antti ^d   Karhunen, Pekka J ^e   Kettunen, Johannes ^a   Perola, Markus ^a,d   Kontula, Kimmo ^a   Newton Cheh, Christopher ^b,c   Salomaa, Veikko ^d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIN; SODIUM CHANNEL NAV1.5;

ADULT; AGE; AGED; ALLELE; ARTICLE; AUTOPSY; CARDIOVASCULAR RISK; CAUSE OF DEATH; CHROMOSOME 4Q; CHROMOSOME 9P; CIGARETTE SMOKING; CLINICAL STUDY; COHORT ANALYSIS; DIABETES MELLITUS; DISEASE REGISTRY; ELECTROCARDIOGRAPHY; FEMALE; FORENSIC PATHOLOGY; GENE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GEOGRAPHY; HUMAN; HUMAN TISSUE; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PHYSICAL ACTIVITY; POPULATION RESEARCH; QT INTERVAL; QT PROLONGATION; SCN5A GENE; SEX; SINGLE NUCLEOTIDE POLYMORPHISM; SUDDEN DEATH; SYSTOLIC BLOOD PRESSURE;

ADULT; ARRHYTHMIAS, CARDIAC; ATRIAL FIBRILLATION; DEATH, SUDDEN, CARDIAC; FEMALE; FINLAND; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; META-ANALYSIS AS TOPIC; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84864216268     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041675     Document Type: Article

References (42)

1. Adabag AS, Luepker RV, Roger VL, Gersh BJ, (2010) Sudden cardiac death: epidemiology and risk factors. Nat Rev Cardiol 7: 216-225.
2. Ni H, Coady S, Rosamond W, Folsom AR, Chambless L, et al. (2009) Trends from 1987 to 2004 in sudden death due to coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. Am Heart J 157: 46-52.
3. Kannel WB, Schatzkin A, (1985) Sudden death: lessons from subsets in population studies. J Am Coll Cardiol 5: 141B-149B.
4. Curb JD, Rodriguez BL, Burchfiel CM, Abbott RD, Chiu D, et al. (1995) Sudden death, impaired glucose tolerance, and diabetes in Japanese American men. Circulation 91: 2591-2595.
5. Wannamethee G, Shaper AG, Macfarlane PW, Walker M, (1995) Risk factors for sudden cardiac death in middle-aged British men. Circulation 91: 1749-1756.
6. Friedlander Y, Siscovick DS, Weinmann S, Austin MA, Psaty BM, et al. (1998) Family history as a risk factor for primary cardiac arrest. Circulation 97: 155-160.
7. Jouven X, Desnos M, Guerot C, Ducimetière P, (1999) Predicting sudden death in the population: the Paris Prospective Study I. Circulation 99: 1978-1983.
8. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, et al. (1995) A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80: 795-803.
9. Wang Q, Shen J, Splawski I, Atkinson D, Li Z, et al. (1995) SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 80: 805-811.
10. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, et al. (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 12: 17-23.
11. Newton-Cheh C, Eijgelsheim M, Rice KM, de Bakker PI, Yin X, et al. (2009) Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet 41: 399-406.
12. Pfeufer A, Sanna S, Arking DE, Müller M, Gateva V, et al. (2009) Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet 41: 407-414.
13. Straus SM, Kors JA, De Bruin ML, van der Hooft CS, Hofman A, et al. (2006) Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol 47: 362-367.
14. Antzelevitch C, Shimizu W, (2002) Cellular mechanisms underlying the long QT syndrome. Curr Opin Cardiol 17: 43-51.
15. Newton-Cheh C, Larson MG, Corey DC, Benjamin EJ, Herbert AG, et al. (2005) QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study. Heart Rhythm 2: 277-284.
16. Cheng S, Keyes MJ, Larson MG, McCabe EL, Newton-Cheh C, et al. (2009) Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block. JAMA 301: 2571-2577.
17. Pedersen OD, Abildstrøm SZ, Ottesen MM, Rask-Madsen C, Bagger H, et al. (2006) Increased risk of sudden and non-sudden cardiovascular death in patients with atrial fibrillation/flutter following acute myocardial infarction. Eur Heart J 27: 290-295.
18. Noseworthy PA, Havulinna AS, Porthan K, Lahtinen AM, Jula A, et al. (2011) Common Genetic Variants, QT Interval, and Sudden Cardiac Death in a Finnish Population-Based Study. Circ Cardiovasc Genet 4: 305-311.
19. Tyynelä P, Goebeler S, Ilveskoski E, Mikkelsson J, Perola M, et al. (2009) Birthplace predicts risk for prehospital sudden cardiac death in middle-aged men who migrated to metropolitan area: The Helsinki Sudden Death Study. Ann Med 41: 57-65.
20. Kok E, Haikonen S, Luoto T, Huhtala H, Goebeler S, et al. (2009) Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age. Ann Neurol 65: 650-657.
21. Vartiainen E, Laatikainen T, Peltonen M, Juolevi A, Männistö S, et al. (2010) Thirty-five-year trends in cardiovascular risk factors in Finland. Int J Epidemiol 39: 504-518.
22. Heistaro S, (2008) Methodology report, Health 2000 Survey. Helsinki: Publications of the National Public Health Institute, KTL B 26. Available:http://www.terveys2000.fi/doc/methodologyrep.pdf. Accessed 2012 Feb 10.
23. Kattainen A, Salomaa V, Härkänen T, Jula A, Kaaja R, et al. (2006) Coronary heart disease: from a disease of middle-aged men in the late 1970s to a disease of elderly women in the 2000s. Eur Heart J 27: 296-301.
24. Inouye M, Silander K, Hamalainen E, Salomaa V, Harald K, et al. (2010) An immune response network associated with blood lipid levels. PLoS Genet 6: e1001113.
25. R Development Core Team (2010) R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing. Available:http://www.r-project.org. Accessed 2012 Feb 10.
26. Higgins JP, Thompson SG, (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539-1558.
27. Newton-Cheh C, Cook NR, VanDenburgh M, Rimm EB, Ridker PM, et al. (2009) A common variant at 9p21 is associated with sudden and arrhythmic cardiac death. Circulation 120: 2062-2068.
28. Gudbjartsson DF, Arnar DO, Helgadottir A, Gretarsdottir S, Holm H, et al. (2007) Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 448: 353-357.
29. Chugh SS, Reinier K, Singh T, Uy-Evanado A, Socoteanu C, et al. (2009) Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: the Oregon Sudden Unexpected Death Study. Circulation 119: 663-670.
30. Kannel WB, Plehn JF, Cupples LA, (1988) Cardiac failure and sudden death in the Framingham Study. Am Heart J 115: 869-875.
31. Adams KF Jr, Patterson JH, Gattis WA, O'Connor CM, Lee CR, et al. (2005) Relationship of serum digoxin concentration to mortality and morbidity in women in the digitalis investigation group trial: a retrospective analysis. J Am Coll Cardiol 46: 497-504.
32. Aydin A, Bähring S, Dahm S, Guenther UP, Uhlmann R, et al. (2005) Single nucleotide polymorphism map of five long-QT genes. J Mol Med 83: 159-165.
33. Gouas L, Nicaud V, Chaouch S, Berthet M, Forhan A, et al. (2007) Confirmation of associations between ion channel gene SNPs and QTc interval duration in healthy subjects. Eur J Hum Genet 15: 974-979.
34. Ruan Y, Liu N, Priori SG, (2009) Sodium channel mutations and arrhythmias. Nat Rev Cardiol 6: 337-348.
35. Franco D, Campione M, (2003) The role of Pitx2 during cardiac development. Linking left-right signaling and congenital heart diseases. Trends Cardiovasc Med 13: 157-163.
36. Mommersteeg MT, Hoogaars WM, Prall OW, de Gier-de Vries C, Wiese C, et al. (2007) Molecular pathway for the localized formation of the sinoatrial node. Circ Res 100: 354-362.
37. Chinchilla A, Daimi H, Lozano-Velasco E, Dominguez JN, Caballero R, et al. (2011) PITX2 Insufficiency Leads to Atrial Electrical and Structural Remodeling Linked to Arrhythmogenesis. Circ Cardiovasc Genet 4: 269-279.
38. Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, et al. (2007) A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316: 1491-1493.
39. Visel A, Zhu Y, May D, Afzal V, Gong E, et al. (2010) Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 464: 409-412.
40. Lahti RA, Penttila A, (2001) The validity of death certificates: routine validation of death certification and its effects on mortality statistics. Forensic Sci Int 115: 15-32.
41. Pajunen P, Koukkunen H, Ketonen M, Jerkkola T, Immonen-Räihä P, et al. (2005) The validity of the Finnish Hospital Discharge Register and Causes of Death Register data on coronary heart disease. Eur J Cardiovasc Prev Rehabil 12: 132-137.
42. Jakkula E, Rehnström K, Varilo T, Pietiläinen OP, Paunio T, et al. (2008) The genome-wide patterns of variation expose significant substructure in a founder population. Am J Hum Genet 83: 787-794.