Spirocyclic nortriterpenoids with NGF-potentiating activity from the fruits of Leonurus heterophyllus

Journal of Natural Products

Volumn 75, Issue 7, 2012, Pages 1353-1358

  Liu, Yuhong ^a,b   Kubo, Miwa ^a   Fukuyama, Yoshiyasu ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LEONURUS HETEROPHYLLUS EXTRACT; LEONURUSOLEANOLIDE A; LEONURUSOLEANOLIDE B; LEONURUSOLEANOLIDE C; LEONURUSOLEANOLIDE D; METHANOL; NERVE GROWTH FACTOR; PLANT EXTRACT; TRITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN; CHEMICAL STRUCTURE; DRUG HYDROLYSIS; DRUG ISOLATION; FRACTIONATION; FRUIT; HETERONUCLEAR MULTIPLE BOND CORRELATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEONURUS HETEROPHYLLUS; MEDICINAL PLANT; NERVE FIBER GROWTH; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; FRUIT; LAMIACEAE; MOLECULAR STRUCTURE; NERVE GROWTH FACTOR; NEURITES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PC12 CELLS; RATS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

LEONURUS JAPONICUS;

EID: 84864206516     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np300287f     Document Type: Article

References (31)

1. Jiang Su New Medical College. Dictionary of Chinese Materia Medica; Shanghai Scientific and Technical Publishing House: Shanghai, 1977; pp 1156-1157.
2. Ho, T. S.; Yu, C. F.; Wang, H. Sci. Sin. 1962, 11, 1341-1344
3. Yeung, H. W.; Kong, Y. C.; Lay, W. P.; Cheng, K. F. Planta Med. 1977, 31, 51-55
4. Yu, C. F. Acta Chim. Sin. 1981, 39, 84-88
5. Hon, P. M.; Lee, C. M.; Shang, H. S.; Cui, Y. X.; Wong, H. N. C.; Chang, H. M. Phytochemistry 1991, 30, 354-356
6. Hon, P. M.; Wang, E. S.; Lam, S. K. M.; Choy, Y. M.; Lee, C. M.; Wong, H. N.C. Phytochemistry 1993, 33, 639-641
7. Giang, P. M.; Son, P. T.; Matsunami, K.; Otsuka, H. Chem. Pharm. Bull. 2005, 53, 938-941
8. Giang, P. M.; Son, P. T.; Matsunami, K.; Otsuka, H. Chem. Pharm. Bull. 2005, 53, 1475-1479
9. Cai, X. H.; Che, C. T.; Lam, C. K.; Mak, T. C.; Wu, L. J. J. Asian Nat. Prod. 2006, 8, 599-603
10. Hung, T. M.; Luan, T. C.; Vinh, B. T.; Cuong, T. D.; Min, B. S. Phytother. Res. 2011, 25, 611-614
11. Cong, Y.; Wang, J. H.; Li, X. J. Asian Nat. Prod. Res. 2005, 7, 273-277
12. Liang, H.; Liu, P.; Wang, Y.; Song, S.; Ji, A. Phytomedicine 2011, 18, 811-818
13. Morita, H.; Gonda, A.; Takeya, K.; Itokawa, H. Bioorg. Med. Chem. Lett. 1996, 6, 767-770
14. Morita, H.; Gonda, A.; Takeya, K.; Itokawa, H.; Iitakai, Y. Tetrahedron 1997, 53, 1617-1626
15. Morita, H.; Iizuka, T.; Gonda, A.; Itokawa, H.; Takeya, K. J. Nat. Prod. 2006, 69, 839-841
16. Kubo, M.; Kishimoto, Y.; Harada, K.; Hioki, H.; Fukuyama, Y. Bioorg. Med. Chem. Lett. 2010, 20, 2566-2571
17. Bayoumi, S. A. L.; Rowan, M. G.; Beeching, J. R.; Blagbrough, I. S. Phytochemistry 2010, 71, 598-604
18. Hong, L.; Jun, H.; Li, X.; Xiang, T. R. Planta Med. 1999, 65, 586-587
19. Cai, J. N.; Basnet, P.; Wang, Z. T.; Komatsu, K.; Xu, L. S.; Tani, T. J. Nat. Prod. 2000, 63, 485-488
20. Budzikiewicz, H.; Wilson, J. M.; Djerassi, C. J. Am. Chem. Soc. 1963, 85, 3688-3699
21. Liu, P.; Yao, Z.; Zhang, W.; Takaishi, Y.; Duan, H. Q. Chem. Pharm. Bull. 2008, 56, 951-955
22. Liu, P.; Yao, Z.; Li, H. Q.; Duan, H. Q. Helv. Chim. Acta 2007, 90, 601-606
23. Thanh, V. T. T.; Pham, V. C.; Nguyen, H. H.; Mai, H. D. T.; Minh, H. N. T.; Nguyen, V. H.; Litaudon, M.; Gueritte, F.; Chau, V. M. Eur. J. Org. Chem. 2011, 4108-4111
24. Luo, Y.; Feng, C.; Tian, Y.; Li, B.; Zhang, G. Tetrahedron 2003, 59, 8227-8232
25. Wang, Q.; Luo, S.; Ju, P.; Wang, Y. Helv. Chim. Acta 2007, 90, 1360-1365
26. Pradines, A.; Magazin, M.; Schiltz, P.; Le Fur, G.; Caput, D.; Ferrara, P. J. Neurochem. 1995, 64, 1954-1964
27. Vaudry, D.; Stork, P. J. S.; Lazarovici, P.; Eiden, L. E. Science 2002, 296, 1648-1653
28. Inoue, M.; Zhai, H.; Sakazaki, H.; Furuyama, H.; Fukuyama, Y.; Hirama, M. Bioorg. Med. Chem. Lett. 2004, 14, 663-665
29. Tang, W.; Kubo, M.; Harada, K.; Hioki, H.; Fukuyama, Y. Bioorg. Med. Chem. Lett. 2009, 19, 882-886
30. Whittemore, S. R.; Seiger, A. Brain Res. Rev. 1987, 12, 439-464
31. Cowan, W. M. Annu. Rev. Neurosci. 2001, 24, 551-600