Inhibition of human neutrophil elastase by α 1-antitrypsin functionalized colloidal microcarriers

ACS Nano

Volumn 6, Issue 7, 2012, Pages 6325-6336

  Reibetanz, Uta ^a   Schönberg, Maria ^a   Rathmann, Sophie ^a   Strehlow, Vincent ^a   Göse, Martin ^a   Leßig, Jacqueline ^a,b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

antitrypsin; biocompatible polyelectrolytes; chronic inflammation; drug delivery; human neutrophil elastase; LbL carriers; polymorphonuclear leukocytes

Indexed keywords

ACTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; ANTITRYPSIN; CHRONIC INFLAMMATION; DRUG MOLECULES; EXTRACELLULAR; EXTRACELLULAR SPACE; FUNCTIONALIZED; HIGH POTENTIAL; HOST TISSUES; HUMAN NEUTROPHIL ELASTASE; INFLAMMATORY PROCESS; INHIBITORY EFFECT; LAYER-BY-LAYERS; MICROCARRIERS; OPPOSITELY CHARGED POLYELECTROLYTES; POLYMORPHONUCLEAR LEUKOCYTES; PROTEOLYTIC ENZYME; REBALANCING; TISSUE DESTRUCTION; TRANSPORT SYSTEMS;

BODY FLUIDS; DRUG DELIVERY; MODULAR CONSTRUCTION; PATHOLOGY; POLYELECTROLYTES; TISSUE;

ENZYME ACTIVITY;

ALPHA 1 ANTITRYPSIN; DRUG CARRIER; LEUKOCYTE ELASTASE; NANOPARTICLE;

ARTICLE; CELL SURVIVAL; CHEMISTRY; COLLOID; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG EFFECT; ENZYMOLOGY; HUMAN; IN VITRO STUDY; NANOTECHNOLOGY; NEUTROPHIL; PROTEIN STABILITY;

ALPHA 1-ANTITRYPSIN; CELL SURVIVAL; COLLOIDS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; LEUKOCYTE ELASTASE; NANOPARTICLES; NANOTECHNOLOGY; NEUTROPHILS; PROTEIN STABILITY;

EID: 84864201827     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn301791w     Document Type: Article

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