A minimal model of tumor growth inhibition in combination regimens under the hypothesis of no interaction between drugs

IEEE Transactions on Biomedical Engineering

Volumn 59, Issue 8, 2012, Pages 2161-2170

  Magni, Paolo ^a   Terranova, Nadia ^a   Del Bene, Francesca ^b   Germani, Massimiliano ^b   De Nicolao, Giuseppe ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b Accelera Srl   (Italy)

Author keywords

Anticancer drug discovery; drug combination regimen; pharmacodynamic models; Poisson models; preclinical studies; stochastic models; tumor growth models; xenograft mice

Indexed keywords

ANTICANCER DRUG DISCOVERY; DRUG COMBINATIONS; PHARMACODYNAMIC MODELS; POISSON MODEL; PRECLINICAL STUDIES; TUMOR GROWTH MODELS; XENOGRAFT MICE;

BIOLOGICAL MATERIALS; CELL DEATH; EXPERIMENTS; MAMMALS; PARTIAL DIFFERENTIAL EQUATIONS; STOCHASTIC MODELS; TUMORS;

DRUG INTERACTIONS;

AREA UNDER THE CURVE; ARTICLE; CELL DAMAGE; CELL DEATH; CELL DIVISION; CELL POPULATION; CELL PROLIFERATION; CELL SUBPOPULATION; CONCEPTUAL FRAMEWORK; DRUG INTERACTION; EXPERIMENTAL MODEL; FINITE ELEMENT ANALYSIS; GROWTH CURVE; HUMAN; IN VIVO STUDY; MATHEMATICAL MODEL; NONHUMAN; NULL HYPOTHESIS; PROBABILITY; STATISTICAL SIGNIFICANCE; STOCHASTIC MODEL; TUMOR CELL; TUMOR GROWTH; TUMOR GROWTH INHIBITION MODEL; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DISCOVERY; DRUG INTERACTIONS; HUMANS; MICE; MODELS, BIOLOGICAL; NEOPLASMS, EXPERIMENTAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84864195162     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2012.2197680     Document Type: Article

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