The flatworm planaria as a toxicology and behavioral pharmacology animal model in undergraduate research experiences

Journal of Undergraduate Neuroscience Education

Volumn 7, Issue 2, 2009, Pages 48-52

  Pagán, Oné R ^a   Coudron, Tamara ^a   Kaneria, Tanvi ^a  

^a WEST CHESTER UNIVERSITY   (United States)

Author keywords

Behavior; Caffeine; Dmso; Motility; Pharmacology; Planaria; Toxicology

Indexed keywords

EID: 84864171026     PISSN: None     EISSN: 15442896     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Agata K, Umesono Y (2008) Brain regeneration from pluripotent stem cells in planarian. Philos Trans R Soc Lond B Biol Sci 363:2071-2078.
2. Balakin KV, Saychuk NP, Tetko IV (2006) In silico approaches to prediction of aqueous and DMSO solubility of drug-like compounds: trends, problems and solutions. Curr Med Chem 13:223-241.
3. Behre EH (1918) An Experimental Study of Acclimation to Temperature in Planaria dorotocephala. Biol Bull 35:277-317.
4. Best JB, Morita M (1991) Toxicology of planarians. Hydrobiologia 227:375-383.
5. Buttarelli FR, Pellicano C, Pontieri FE (2008) Neuropharmacology and behavior in planarians: translations to mammals. Comp Biochem Physiol C Toxicol Pharmacol 147:399-408.
6. Buttarelli FR, Pontieri FE, Margotta V, Palladini G. (2002) Cannabinoid-induced stimulation of motor activity in planaria through an opioid receptor-mediated mechanism. Prog Neuropsychopharmacol Biol Psychiatry 26:65-68.
7. Buttarelli FR, Pontieri FE, Margotta V, Palladini G (2000) Acetylcholine/dopamine interaction in planaria. Comp Biochem Physiol C Toxical Pharmacol 125:225-231.
8. Castroman PJ, Ness TJ (2002) Spinal neurophysiologic correlates of the analgesic actions of intravesical dimethyl sulfoxide and capsaicin in the rat. J Pain 3:394-400.
9. Cebrià F (2007) Regenerating the central nervous system: how easy for planarians! Dev Genes Evol 217:733-748
10. Evans MS, Reid KH, Sharp JB (1993) Dimethylsulfoxide (DMSO) blocks conduction in peripheral nerve C fibers: a possible mechanism of analgesia. Neurosci Lett 150:145-148.
11. Grebe E, Schaeffer DJ (1991) Planarians in toxicology, standardization of a rapid neurobehavioral toxicity test using phenol in a crossover study. Bull Environ Contam Toxicol 46:866-870.
12. Hinrichs MA (1924) A study of the physiological effects of caffein upon Planaria dorotocephala. J Exp Zool 40:271-300.
13. Kapu MM, Schaeffer DJ (1991) Planarians in toxicology. Responses of asexual Dugesia dorotocephala to selected metals. Bull Environ Contam Toxicol 47:302-307.
14. Kusayama T, Watanabe S (2000) Reinforcing effects of methamphetamine in planarians. Neuroreport 11:2511-2513.
15. Li MH (2008) Effects of nonionic and ionic surfactants on survival, oxidative stress, and cholinesterase activity of planarian. Chemosphere 70:1796-1803.
16. Nehlig A, Daval JL, Debry G (1992) Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev 17:139-170.
17. Newmark PA, Sánchez Alvarado A (2002) Not your father's planarian: a classic model enters the era of functional genomics. Nat Rev Genet 3:210-219.
18. Pagán OR, Rowlands AL, Azam M, Urban KR, Bidja AH, Roy DM, Feeney RB, Afshari LK (2008). Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones. Pharmacol Biochem Behav 89:160-170.
19. Pagán OR, Rowlands AL, Urban KR (2006) Toxicity and behavioral effects of dimethylsulfoxide in planaria. Neurosci Lett 407:274-278.
20. Palladini G, Ruggeri S, Stocchi F, De Pandis MF, Venturini G, Margotta V (1996) A pharmacological study of cocaine activity in planaria. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 115:41-45.
21. Raffa RB, Desai P (2005) Description and quantification of cocaine withdrawal signs in Planaria. Brain Res 1032:200-202.
22. Raffa RB, Holland LJ, Schulingkamp RJ (2001) Quantitative assessment of dopamine D2 antagonist activity using invertebrate (Planaria) locomotion as a functional endpoint. J Pharmacol Toxicol Methods 45:223-226.
23. Ribeiro P, El-Shehabi F, Patocka N (2005) Classical transmitters and their receptors in flatworms. Parasitology 131:Suppl:S19-40.
24. Rowlands AL, Pagán OR (2008) Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians. Eur J Pharmacol 583:170-172.
25. Sabourin TD, Faulk RT, Goss LB (1985) The efficacy of three non-mammalian test systems in the identification of chemical teratogens. J Appl Toxicol 5:227-233.
26. Sarnat HB, Netsky MG (1985) The brain of the planarian as the ancestor of the human brain. Can J Neurol Sci 12:296-302.
27. Sarnat HB, Netsky MG (2002) When does a ganglion become a brain? Evolutionary origin of the central nervous system. Semin Pediatr Neurol 9:240-253.
28. Schaeffer DJ (1993) Planarians as a model system for in vivo teratogenesis studies. Qual Assur 2:265-318.
29. Weiss JN (1997) The Hill equation revisited: uses and misuses. FASEB J:11:835-841.
30. Yun AJ, Doux JD, Daniel SM (2007) Brewing controversies: Darwinian perspective on the adaptive and maladaptive effects of caffeine and ethanol as dietary autonomic modulators. Med Hypotheses 68:31-36.