Clonality in gynecologic neoplasms: Is it time to reevaluate clonality studies in gynecologic neoplasms? Is it possible to confirm multicentricity with clonality studies?

Annals of Diagnostic Pathology

Volumn 16, Issue 4, 2012, Pages 312-314

  Silva, Elvio G ^a   Matias Guiu, Xavier ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Clonality; Gynecologic neoplasms; Multicentricity

Indexed keywords

CARCINOGENESIS; CLONAL VARIATION; DATA ANALYSIS; FEMALE; FEMALE GENITAL TRACT TUMOR; GENETIC VARIABILITY; HUMAN; METASTASIS; PRIORITY JOURNAL; REVIEW;

CELL TRANSFORMATION, NEOPLASTIC; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENITAL NEOPLASMS, FEMALE; HUMANS; NEOPLASM METASTASIS; NEOPLASMS, MULTIPLE PRIMARY;

EID: 84864143607     PISSN: 10929134     EISSN: 15328198     Source Type: Journal    
DOI: 10.1016/j.anndiagpath.2012.01.007     Document Type: Review

References (26)

1. S. Noguchi, K. Motomura, H. Inaji, S. Imaoka, and H. Koyama Clonal analysis of fibroadenoma and phyllodes tumor of the breast Cancer Res 53 1993 4071
2. S.B. Garcia, M. Novelli, and N.N. Wright The clonal origin and clonal evolution of epithelial tumors Int. J. Exp. Path 81 2000 89 116 (Pubitemid 30253350)
3. C. Hatakeyama, C.L. Anderson, C.L. Beever, M.S. Penaherrera, C.J. Brown, and W.P. Robinson The dynamics of X-inactivation skewing as women age Clin Genet 66 4 2004 327 332 (Pubitemid 39317634)
4. S.J. Leedham, and W.N. Human Tumour clonality assessment-flawed but necessary J Pathol 215 4 2008 351 354
5. W.M. Lin, E. Forgacs, D.P. Warshal, I.T. Yeh, J.S. Martin, R. Ashfaq, and C.Y. Muller Loss of Heterozygosity and Mutational Analysis of the PTEN/MMAC1 Gene in Synchronous Endometrial and Ovarian Carcinomas Clin Cancer Res 6 4 1998 2577 2593
6. R. Sciot, P. Dal Cin, J. Bellemans, I. Samson, H. Van den Berghe, and B. Van Damme Case report: synovial chondromatosis: clonal chromosome changes provide further evidence for a neoplastic disorder Virchows Archiv 433 2 1998 189 191 (Pubitemid 28401177)
7. T. Yano, H. Jimbo, H. Yoshikawa, O. Tsutsumi, and Y. Taketani Molecular analysis of clonality in ovarian endometrial cysts Gynecol Obstet Invest 47 1 1999 41 45
8. S. Denzinger, K. Mohren, R. Knuechel, P. Wild, M. Burger, and W. Wieland Improved clonality analysis of multifocal bladder tumors by combination of histopathologic organ mapping, loss of heterozygosity, fluorescence in situ hybridization, and p53 analyses Hum Pathol 37 2 2006 143 151 (Pubitemid 43099833)
9. C. Hafner, R. Knuechel, R. Stoehr, and A. Hartmann Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies Int J Cancer 101 1 2002 1 6 (Pubitemid 34832989)
10. R. McCarthy, M. Wang, T.D. Jones, R.W. Strate, and L. Cheng Molecular evidence for the same clonal origin of multifocal papillary thyroid carcino Clin Cancer Res 12 2006 2414 2418
11. S. Moniz, A.L. Catarino, A.R. Marques, B. Cavaco, L. Sobrinho, and V. Leite Clonal origin of non-medulary thyroid tumours assessed by non-random X-chromosome inactivation Eur J Endocrinol 146 2002 27 33 (Pubitemid 34126415)
12. H. Fujii, T. Matsumoto, M. Yoshida, Y. Furugen, T. Takagaki, and K. Iwabuchi Genetics of synchronous uterine and ovarian endometrioid carcinoma: combined analyses of loss of heterozygosity, PTEN mutation, and microsatellite instability Human Pathol 33 4 2002 421 428 (Pubitemid 34627593)
13. J. Irving, L. Catasús, A. Gallardo, E. Bussaglia, M. Romero, and X. Matias-Guiu Synchronous endometrioid carcinomas of the uterine corpus and ovary: alterations in the B-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis Hum Pathol 36 6 2005 605 619 (Pubitemid 40922566)
14. J. Kupryjanczyk, A.D. Thor, R. Beauchamp, C. Poremba, R.E. Scully, and D.W. Yandell Ovarian, peritoneal, and endometrial serous carcinoma: clonal origin of multifocaldisease Mod Pathol 9 3 1996 166 173 (Pubitemid 26126539)
15. 1 mutations JNCI J Natl Cancer Inst 90 11 1998 841 845 (Pubitemid 28280550)
16. N.L. Sieben, S.M. Kolkman-Uljee, A.M. Flanagan, S. le Cessie, A.M. Cleton-Jansen, and C.J. Cornelisse Molecular genetic evidence for monoclonal origin of bilateral ovarian serous borderline tumors Am J Pathol 162 4 2003 1095 1101 (Pubitemid 36350655)
17. B.J. Quade, C.M. McLachlin, V. Soto-Wright, J. Zuckerman, G.L. Mutter, and C.C. Morton Disseminated peritoneal leiomyomatosis. Clonality analysis by X chromosome inactivation and cytogenetics of a clinically benign smooth muscle proliferation Am J Pathol 150 6 1997 2153 2166 (Pubitemid 27233086)
18. D.P. Slaughter, H.W. Southwick, and W. Smejkal Field Cacnerization in oral stratified squamous epithelium Am Cancer Soc 6 5 1953 963 968
19. C.H. Mok, S.W. Tsao, R.C. Knapp, P.M. Fishbaugh, and C.C. Lau Unifocal origin of advanced human epithelial ovarian cancers Cancer Res 52 1992 5119 5122
20. C. Szych, A. Staebler, D.C. Connolly, R. Wu, K.R. Cho, and B.M. Ronnett Molecular genetic evidence supporting the clonality and appendiceal origin of Pseudomyxoma peritonei in women Am J Pathol 154 6 1999 1849 1855 (Pubitemid 29262868)
21. C. Hafner, A. Toll, A. Fernandex-Casado, J. Earl, M. Marques, and F. Acquadro Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epiderma tumors Proc Natl Acad Sci USA 107 48 2010 20780 20785
22. I.J. Jacobs, M.F. Kohler, R.W. Wiseman, J.R. Marks, R. Whitaker, B.A.J. Kerns, P. Humphrey, A. Berchuck, B.A.J. Ponder, and R.C. Bast Clonal origin of epithelial ovarian carcinoma: analysis by Loss of heterozygosity, P53 mutation, and X-chromosome inactivation JNCI J Natl Cancer Ins 84 23 1992 1793 1798
23. R. Buller, S.J. Skilling, A. Sood, S. Plaxe, R. Baergen, and D. Lager Field cancerization: why late recurrent ovarian cancer is not recurrent Am J Obstet Gynecol 178 4 1999 641 649 (Pubitemid 28196869)
24. K.H. Chang, C. Albarracin, L. Luthra, W. Wang, A. Zheng, and A. Malpica Discordant genetic changes in ovarian and endometrial endometrioid carcinomas: a potential pitfall in molecular diagnosis Int J Gynecol Cancer 16 1 2006 178 182
25. J. Gu, L.M. Roth, C. Younger, H. Michael, F. Abdul-Karim, and S. Zhang Molecular evidence for the independent origin of extra-ovarian papillary serous tumors of low malignant potential JNCI J Natl Cancer Inst 93 15 2001 1147 1152 (Pubitemid 32780966)
26. L. Khalique, A. Ayhan, M.E. Weale, I.J. Jacobs, S.J. Ramus, and S.A. Gayther Genetic intra-tumour heterogeneity in epithelial ovarian cancer and its implication for molecular diagnosis of tumours6 J Pathol 211 3 2007 286 295 (Pubitemid 46172704)