Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators

Toxicology and Applied Pharmacology

Volumn 263, Issue 1, 2012, Pages 122-130

  Vaid, Mudit ^b   Prasad, Ram ^b   Singh, Tripti ^b   Jones, Virginia ^b   Katiyar, Santosh K ^a,b  

^a BIRMINGHAM VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

DNA methylation; Grape seed proanthocyanidins; Histone acetylation; Skin cancer cells; Tumor suppressor genes and proteins

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; 5 METHYLCYTOSINE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; GRAPE SEED EXTRACT; HISTONE DEACETYLASE; HISTONE H3; HISTONE H4; LYSINE; MESSENGER RNA; PROANTHOCYANIDIN; PROTEIN P21; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

ARTICLE; CANCER CELL; CIP1 TUMOR SUPPRESSOR GENE; CONTROLLED STUDY; DNA METHYLATION; DRUG TARGETING; ENZYME ACTIVITY; EPIGENETICS; GENE ACTIVATION; GENE EXPRESSION; GENE SILENCING; GENETIC REGULATION; GRAPE; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; P16 INK4A TUMOR SUPPRESSOR GENE; P21 TUMOR SUPPRESSOR GENE; PROTEIN EXPRESSION; RASSF1A TUMOR SUPPRESSOR GENE; SKIN CANCER; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; AZACITIDINE; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DNA METHYLATION; GENE SILENCING; GENES, TUMOR SUPPRESSOR; GRAPE SEED EXTRACT; HISTONE ACETYLTRANSFERASES; HUMANS; IMMUNOBLOTTING; PROANTHOCYANIDINS; REAL-TIME POLYMERASE CHAIN REACTION; SKIN NEOPLASMS;

VITACEAE;

EID: 84864139600     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.06.013     Document Type: Article

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