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Volumn 5, Issue 2, 2012, Pages 121-123

Bioengineered factor Xa as a potential new strategy for hemophilia therapy

Author keywords

bypass agents; factor Xa; hemophilia; hemostasis

Indexed keywords

ANTITHROMBIN III; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; PROTEIN C; PROTHROMBIN COMPLEX; THROMBOPLASTIN; TISSUE FACTOR PATHWAY INHIBITOR; BLOOD CLOTTING FACTOR 5A;

EID: 84864111891     PISSN: 17474086     EISSN: 17474094     Source Type: Journal    
DOI: 10.1586/ehm.12.13     Document Type: Review
Times cited : (5)

References (21)
  • 1
    • 65349111124 scopus 로고    scopus 로고
    • Overview of inherited hemorrhagic disorders
    • (5Thedition). Colman RW, Marder VJ, Clowes AW, Gerorge JN, Goldhaber SZ (Eds). Lippincott Williams & Wilkins, PA, USA
    • Roberts HR, Ma AD. Overview of inherited hemorrhagic disorders. In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice (5Thedition). Colman RW, Marder VJ, Clowes AW, Gerorge JN, Goldhaber SZ (Eds). Lippincott Williams & Wilkins, PA, USA, 877-885 (2006).
    • (2006) Hemostasis and Thrombosis: Basic Principles and Clinical Practice , pp. 877-885
    • Roberts, H.R.1    Ma, A.D.2
  • 2
    • 0025311157 scopus 로고
    • Surface dependent reactions of the vitamin K-dependent enzyme complexes
    • Mann KG, Nesheim ME, Church WR, Haley PE, Krishnaswamy S. Surface dependent reactions of the vitamin K-dependent enzyme complexes. Blood 76(1), 1-16 (1990).
    • (1990) Blood , vol.76 , Issue.1 , pp. 1-16
    • Mann, K.G.1    Nesheim, M.E.2    Church, W.R.3    Haley, P.E.4    Krishnaswamy, S.5
  • 3
    • 44249093256 scopus 로고    scopus 로고
    • Back to the future: A recent history of haemophilia treatment
    • Mannucci PM. Back to the future: a recent history of haemophilia treatment. Haemophilia 14(Suppl. 3), 10-18 (2008).
    • (2008) Haemophilia , vol.14 , Issue.SUPPL. 3 , pp. 10-18
    • Mannucci, P.M.1
  • 5
    • 39649106357 scopus 로고    scopus 로고
    • Tissue factor and factor VIIa as therapeutic targets in disorders of hemostasis
    • Hedner U, Ezban M. Tissue factor and factor VIIa as therapeutic targets in disorders of hemostasis. Annu. Rev. Med. 59, 29-41 (2008).
    • (2008) Annu. Rev. Med. , vol.59 , pp. 29-41
    • Hedner, U.1    Ezban, M.2
  • 6
    • 63049090494 scopus 로고    scopus 로고
    • Differential response to bypassing agents complicates treatment in patients with haemophilia and inhibitors
    • Berntorp E. Differential response to bypassing agents complicates treatment in patients with haemophilia and inhibitors. Haemophilia 15(1), 3-10 (2009).
    • (2009) Haemophilia , vol.15 , Issue.1 , pp. 3-10
    • Berntorp, E.1
  • 7
    • 79958144891 scopus 로고    scopus 로고
    • Recent advances in the development of coagulation factors and procoagulants for the treatment of hemophilia
    • Schaub RG. Recent advances in the development of coagulation factors and procoagulants for the treatment of hemophilia. Biochem. Pharmacol. 82(2), 91-98 (2011).
    • (2011) Biochem. Pharmacol. , vol.82 , Issue.2 , pp. 91-98
    • Schaub, R.G.1
  • 8
    • 29244443415 scopus 로고    scopus 로고
    • Factor v Leiden improves in vivo hemostasis in murine hemophilia models
    • Schlachterman A, Schuettrumpf J, Liu JH et al. Factor V Leiden improves in vivo hemostasis in murine hemophilia models. J. Thromb. Haemost. 3(12), 2730-2737 (2005).
    • (2005) J. Thromb. Haemost. , vol.3 , Issue.12 , pp. 2730-2737
    • Schlachterman, A.1    Schuettrumpf, J.2    Liu, J.H.3
  • 9
    • 33750058557 scopus 로고    scopus 로고
    • Peptidomimetic inhibitors for activated protein C: Implications for hemophilia management
    • Butenas S, Orfeo T, Kalafatis M, Mann KG. Peptidomimetic inhibitors for activated protein C: implications for hemophilia management. J. Thromb. Haemost. 4(11), 2411-2416 (2006).
    • (2006) J. Thromb. Haemost. , vol.4 , Issue.11 , pp. 2411-2416
    • Butenas, S.1    Orfeo, T.2    Kalafatis, M.3    Mann, K.G.4
  • 10
  • 11
    • 38349145384 scopus 로고    scopus 로고
    • Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A
    • Prasad S, Lillicrap D, Labelle A et al. Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A. Blood 111(2), 672-679 (2008).
    • (2008) Blood , vol.111 , Issue.2 , pp. 672-679
    • Prasad, S.1    Lillicrap, D.2    Labelle, A.3
  • 12
    • 79956299608 scopus 로고    scopus 로고
    • Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor
    • Waters EK, Genga RM, Schwartz MC et al. Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor. Blood 117(20), 5514-5522 (2011).
    • (2011) Blood , vol.117 , Issue.20 , pp. 5514-5522
    • Waters, E.K.1    Genga, R.M.2    Schwartz, M.C.3
  • 13
    • 0023720558 scopus 로고
    • A combination of factor Xa and phosphatidylcholine-phosphatidylserine vesicles bypasses factor VIII in vivo
    • Giles AR, Mann KG, Nesheim ME. A combination of factor Xa and phosphatidylcholine-phosphatidylserine vesicles bypasses factor VIII in vivo. Br. J. Haematol. 69(4), 491-497 (1988).
    • (1988) Br. J. Haematol. , vol.69 , Issue.4 , pp. 491-497
    • Giles, A.R.1    Mann, K.G.2    Nesheim, M.E.3
  • 14
    • 49649122047 scopus 로고    scopus 로고
    • The conformational switch from the factor X zymogen to protease state mediates exosite expression and prothrombinase assembly
    • Toso R, Zhu H, Camire RM. The conformational switch from the factor X zymogen to protease state mediates exosite expression and prothrombinase assembly. J. Biol. Chem. 283(27), 18627-18635 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.27 , pp. 18627-18635
    • Toso, R.1    Zhu, H.2    Camire, R.M.3
  • 15
    • 80755125572 scopus 로고    scopus 로고
    • A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia
    • Ivanciu L, Toso R, Margaritis P et al. A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia. Nat. Biotechnol. 29(11), 1028-1033 (2011).
    • (2011) Nat. Biotechnol. , vol.29 , Issue.11 , pp. 1028-1033
    • Ivanciu, L.1    Toso, R.2    Margaritis, P.3
  • 16
    • 0036908074 scopus 로고    scopus 로고
    • A fully recombinant partial prothrombin complex effectively bypasses fVIII in vitro and in vivo
    • Himmelspach M, Richter G, Muhr E et al. A fully recombinant partial prothrombin complex effectively bypasses fVIII in vitro and in vivo. Thromb. Haemost. 88(6), 1003-1011 (2002).
    • (2002) Thromb. Haemost. , vol.88 , Issue.6 , pp. 1003-1011
    • Himmelspach, M.1    Richter, G.2    Muhr, E.3
  • 17
    • 0346874351 scopus 로고    scopus 로고
    • A novel therapeutic approach combining human plasma-derived factors VIIa and X for haemophiliacs with inhibitors: Evidence of a higher thrombin generation rate in vitro and more sustained haemostatic activity in vivo than obtained with factor VIIa alone
    • Tomokiyo K, Nakatomi Y, Araki T et al. A novel therapeutic approach combining human plasma-derived factors VIIa and X for haemophiliacs with inhibitors: evidence of a higher thrombin generation rate in vitro and more sustained haemostatic activity in vivo than obtained with factor VIIa alone. Vox Sang. 85(4), 290-299 (2003).
    • (2003) Vox Sang , vol.85 , Issue.4 , pp. 290-299
    • Tomokiyo, K.1    Nakatomi, Y.2    Araki, T.3
  • 18
    • 0028811109 scopus 로고
    • Procoagulant activity of reversibly acylated human factor Xa
    • Wolf DL, Lin PH, Hollenbach S et al. Procoagulant activity of reversibly acylated human factor Xa. Blood 86(11), 4153-4157 (1995).
    • (1995) Blood , vol.86 , Issue.11 , pp. 4153-4157
    • Wolf, D.L.1    Lin, P.H.2    Hollenbach, S.3
  • 19
  • 20
    • 0031956497 scopus 로고    scopus 로고
    • Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes
    • Khan AM, James MNG. Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes. Prot. Sci. 7(4), 815-836 (1998).
    • (1998) Prot. Sci. , vol.7 , Issue.4 , pp. 815-836
    • Khan, A.M.1    James, M.N.G.2
  • 21
    • 78650988916 scopus 로고    scopus 로고
    • Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro
    • Bunce MW, Toso R, Camire RM. Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitro. Blood 117(1), 290-298 (2011).
    • (2011) Blood , vol.117 , Issue.1 , pp. 290-298
    • Bunce, M.W.1    Toso, R.2    Camire, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.