Interaction of -55CT polymorphism of UCP3 gene with Trp64Arg polymorphism of beta3adrenoreceptor gene on insulin resistance in obese patients

European Review for Medical and Pharmacological Sciences

Volumn 16, Issue 5, 2012, Pages 610-616

  De Luis, D A ^a   Aller, R ^a   Izaola, O ^a   Sagrado, M Gonzalez ^a   Conde, R ^a   Castro, M J ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

55CT UCP3; Adipocytokines; Cardiovascular risk factor; Obesity; Trp64Arg beta 3 adrenoreceptor

Indexed keywords

ADIPOCYTOKINE; ARGININE; BETA ADRENERGIC RECEPTOR; CYTOSINE; FAT; THYMINE; TRYPTOPHAN; UNCOUPLING PROTEIN 3; ADRB3 PROTEIN, HUMAN; BETA 3 ADRENERGIC RECEPTOR; INSULIN; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 3; TRIACYLGLYCEROL;

ADULT; BODY MASS; BODY WEIGHT; CHEMICAL ANALYSIS; CONTROLLED STUDY; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MUTANT; OBESITY; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REVIEW; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO; WILD TYPE; ANALYSIS OF VARIANCE; ARTICLE; BLOOD; CHI SQUARE DISTRIBUTION; GENETIC PREDISPOSITION; GENETICS; IMPEDANCE; MIDDLE AGED; PATHOPHYSIOLOGY; PHENOTYPE; PREDICTIVE VALUE; RISK ASSESSMENT; RISK FACTOR; SPAIN;

ADIPOKINES; ADIPOSITY; ADULT; ANALYSIS OF VARIANCE; BLOOD GLUCOSE; BODY MASS INDEX; CHI-SQUARE DISTRIBUTION; ELECTRIC IMPEDANCE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INSULIN; INSULIN RESISTANCE; ION CHANNELS; MALE; MIDDLE AGED; MITOCHONDRIAL PROTEINS; MUTATION, MISSENSE; OBESITY; PHENOTYPE; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; PROMOTER REGIONS, GENETIC; RECEPTORS, ADRENERGIC, BETA-3; RISK ASSESSMENT; RISK FACTORS; SPAIN; TRIGLYCERIDES; WAIST CIRCUMFERENCE; WAIST-HIP RATIO;

EID: 84864085726     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (29)

1. VIDAL PUIG A, SOLANES G, GRUJIC D, FLIER J, LOWELL BB. UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun 1997; 235:v79-82.
2. SALTZMAN E, ROBERTS SB. The role of energy expenditure in energy regulation: Findings from a decade research. Nutr Rev 1995; 53: 209-220.
3. BOUCHARD C, PERUSSE L, CHAGNON YC, WARDEN C, RICQUIER D. Linkage between markers in the vicinity of uncoupling protein 2 gene and resisting metabolic rate in humans. Hum Mol Genet 1997; 6: 1887-1889.
4. CLAPHAM J, ARCH J, CHAPMAN H. Mice overexpressing human uncoupling protein 3 in skeletal muscle are hyperphagic lean. Nature 2000; 406: 415-418.
5. SAMEC S, SEYDOUX J, DULLO A. Role of UCP homologues in skeletal muscle and free fatty acids in obesity. Lancet 1998; 351: 1933-1934.
6. SCHRAUWEN P, XIA XIA J, WALDER K, SNITKER S, RAVUSSIN E. A novel polymorphism in the proximal UCP3 promoter region: Effect on skeletal muscle. UCP3 m RNA expression and obesity in male non-diabetic Pima Indians. Int J Obes 1999; 23: 1242-1245.
7. OTABE S, CLEMENT K, DINA C. A genetic variation in the 5flanking region of the UCP3 is associated with body mass index in humans in interaction with physical activity. Diabetologia 2000; 43: 245-249.
8. MEIRHAEGHE A, AMOYEL P, HELBECQUE N. An uncoupling protein 3 gene polymorphism associated with a lower risk of developing type 2 diabetes and with atherogenic lipid profile in a French cohort. Diabetologia 2000; 43: 1424-1428.
9. ALONSO A, MARTI A, CORBALAN MS, MARTINEZ GONZALEZ MA, FORGA L, MARTINEZ JA. Association of UCP3 gene -55CT polymorphism and obesity in a Spanish population. Ann Nutr Metab 2005; 49: 183-188.
10. ROSENBAUM M, LEIBEL RL, HIRSH J. Medical progress: Obesity. N Engl J Med 1997; 337: 396-407.
11. THOMAS GN, TOMLINSON B, CHANG JCN, YOUNG RP, CRITCHLEY JAJH. The Trp64Arg polymorphism of the beta 3 adrenergic receptor gene and obesity in Chinese subjects with components of the metabolic syndrome. Int J Obes Relat Metab Disord 2000; 25: 545-551.
12. FOGELHOLM M, VALVE R, KUKKONEN K, NENONEM A, HAKKARAINEN V, LAAKSO M, UUSITUPA M. Additive effects of the mutations in the beta 3 adrenergic receptor and uncoupling protein 1 gene on weight loss and weight maintenance in Finnish women. J Clin Endocrinol Metab 1998; 83: 4246-4250.
13. MATTHEWS DR, HOSKER JP, RUDENSKI AS, NAYLOR BA, TREACHER DF, TURNER RC. Homeostasis model assessment: Insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-414.
14. LUKASKI HC, JOHNSON PE, BOLONCHUK WW, LYKKEN GI. Assessment of fat-free mass using bioelectrical impedance measurements of the human body. Am J Clin Nutr 1985; 41: 810-817.
15. YOSHIDA T, SAKANE N, UMEKAWA T, SAKAI Y, TAKAHASHI T, KONDO M. Mutation of beta 3 adrenoreceptor gene and response to treatment of obesity. Lancet 1995; 346: 1433-1444.
16. URHAMMER SA, CLAUSEN JO, HANSEN T, PEDERSEN O. Insulin sensitivity and body weight changes in young white carriers of the codon 64 amino acid polymorphism of the beta 3 adrenergic recetor gene. Diabetes 1996; 45: 1115-1120.
17. DE LUIS DA, ALLER R, IZOALA O, GONZALEZ SAGRADO M, CONDE R. Relation of trp64Arg Polymorphism of Beta 3 adrenoreceptor gene with adipocytokines and fat distribution in obese patients. Ann Nutr Metab 2008; 52: 267-272.
18. SAKANE N, YOSHIDA T, UMEKAWA T, KOGURE A, TAKAKURA Y, KONDO M. Effects of Trp64Arg mutation in the beta 3 adrenoreceptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients. Diabetes Care 1997; 20: 1887-1992.
19. SUSULIC VS, FREDERICH RC, LAWITTS J, TOZZO E, KAHN BB, HARPER ME, HIMMS-HAGEN J, FILER JS. Targeted disruption of the beta 3 adrenergic receptor gene. Endocrinology 1995; 270: 29483-29492.
20. HOFFSTEDT J, WAHRENBERG H, THOME A, LÖNNQVIST F. The metabolic syndrome is related to beta 3 adrenoreceptor sensitivity in visceral adipose tissue. Diabetología 1996; 39: 838-844.
21. KIM OY, CHO EY, PARK HY, JANG Y, LEE JH. Additive effect of the mutations in the beta 3 adrenoreceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome. Int J Obesity 2004; 28: 434-441.
22. WIDEN E, LEHTO M, KANNINEN T, WALTSON J, SCHULDINER AR, GROOP LC. Association of a polymorphism in the beta 3 adrenoreceptor gene with features of the insulin resistance syndrome in Finns. N Engl J Med 1995; 333: 348-351.
23. HESSELINK MKC, MENSINK M, SCHRAUWEN. Human uncoupling protein-3 and obesity. Obesity Res 2003; 11; 1429-1440.
24. DALGAARD LT, SORENSEN TIA, DRIVSHOM T, BORCH JOHNSEN K, ANDERSEN T, HANSEN T. A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population. J Clin Endoc Metab 2001; 86: 1398-1402.
25. DE LUIS DA, GONZALEZ SAGRADO M, CONDE R, ALLER R, IZAOLA O. Lack of association of -55ct polymorphism of UCP3 gene with fat distribution in obese patients. Ann Nutr Metab 2007; 51: 374-378.
26. LIU YJ, LIU PY, LONG J, LU Y, ELZE L, RECKER RR, DENG HW. Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families. Physiol Genomics 2005; 22: 197-203.
27. CASSELL PG, SAKER PJ, HUXTABLE SJ, KOUSTA E, JACKSON AE, HATTERSLE AT. Evidence that single nucleotide polymorphism in the uncoupling protein 3 gene influences fat distribution in women of European and Asian origin. Diabetologia 2000; 43: 1558-1564.
28. MEIRHAEGHE A, AMOUYEL P, HELBECQUE N, COTTEL D, OTABE S, FROGUEL P, VASSEUR F. An uncoupling protein 3 gene polymorphism associated with a lower risk of developing type II diabetes and with atherogenic lipid profile in a French cohort. Diabetologia 2000; 43: 1424-1428.
29. COATS AJ. Ethical authorship and publishing. Int J Cardiol 2009; 131: 149-50.