An intact kidney slice model to investigate vasa recta properties and function in situ

Nephron - Physiology

Volumn 120, Issue 3, 2012, Pages

  Crawford, C ^a   Kennedy Lydon, T ^b   Sprott, C ^b   Desai, T ^b   Sawbridge, L ^b   Munday, J ^b   Unwin, R J ^c   Wildman, S S P ^a   Peppiatt Wildman, C M ^a  

^a MEDWAY SCHOOL OF PHARMACY   (United Kingdom)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Hemodynamics; Innervation; Kidney; Live kidney slice model; Medulla; Microvasculature; Tissue slicing; Tubulovascular crosstalk

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANGIOTENSIN II; CALCEIN; CYCLOOXYGENASE 1; ENDOTHELIN 1; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NORADRENALIN; PROPIDIUM IODIDE; PROSTAGLANDIN E2; TYRAMINE;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL FUNCTION; CELL DENSITY; CELL STRUCTURE; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; KIDNEY BLOOD VESSEL; MALE; NONHUMAN; PERICYTE; PRIORITY JOURNAL; RAT; TISSUE SLICE;

ADENOSINE TRIPHOSPHATE; ANGIOTENSIN II; ANIMALS; ANTIGENS; CAPILLARIES; CELL SURVIVAL; ENDOTHELIN-1; ENZYME INHIBITORS; IMMUNOHISTOCHEMISTRY; INDOMETHACIN; KIDNEY MEDULLA; MALE; MICROSCOPY, CONFOCAL; NG-NITROARGININE METHYL ESTER; NOREPINEPHRINE; PERICYTES; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 84864085401     PISSN: None     EISSN: 16602137     Source Type: Journal    
DOI: 10.1159/000339110     Document Type: Article

References (43)

1. Pallone TL, Zhang Z, Rhinehart K: Physiology of the renal medullary microcirculation. Am J Physiol Renal Physiol 2003; 284:F253-F266. (Pubitemid 36114688)
2. 2-receptor agonists on intrarenal blood flow. Am J Physiol 1993; 265:F802-F806.
3. Mattson DL, Roman RJ, Cowley AW Jr: Role of nitric oxide in renal papillary blood flow and sodium excretion. Hypertension 1992; 19: 76 6-769.
4. Mattson DL, Lu S, Roman RJ, Cowley AW Jr: Relationship between renal perfusion pressure and blood flow in different regions of the kidney. Am J Physiol 1993; 264:R578-R583. (Pubitemid 23109908)
5. Roman RJ: Pressure-diuresis in volume-expanded rats. Tubular reabsorption in superficial and deep nephrons. Hypertension 1988; 12:177-183.
6. Cupples WA, Marsh DJ: Autoregulation of blood flow in renal medulla of the rat: no role for angiotensin II. Can J Physiol Pharmacol 1988; 66: 833-836.
7. Peppiatt CM, Howarth C, Mobbs P, Attwell D: Bidirectional control of CNS capillary diameter by pericy tes. Nature 2006; 443: 70 0-704. (Pubitemid 44564713)
8. Pallone TL, Robertson CR, Jamison RL: Renal medullary microcirculation. Physiol Rev 1990; 70:885-920. (Pubitemid 20196052)
9. 2. Am J Physiol 1994; 266:F850-F857.
10. Pallone TL, Silldorff EP, Cheung JY: Response of isolated rat descending vasa recta to bradykinin. Am J Physiol 1998; 274:H752-H759.
11. Rhinehart KL, Pallone TL: Nitric oxide generation by isolated descending vasa recta. Am J Physiol Heart Circ Physiol 2001; 281:H316-H324.
12. 2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat. J Clin Invest 1995; 95:2734-2740.
13. Silldorff EP, Kreisberg MS, Pallone TL: Adenosine modulates vasomotor tone in outer medullary descending vasa recta of the rat. J Clin Invest 1996; 98:18-23. (Pubitemid 26243815)
14. Silldorff EP, Pallone TL: Adenosine signaling in outer medullary descending vasa recta. Am J Physiol Regul Integr Comp Physiol 2001; 280:R854-R861.
15. Thiel G, de Rougemont D, Kriz W, Mason J, Torhorst J, Wolgast M: The role of reduced medullary perfusion in the genesis of acute ischemic renal failure. Summary of a roundtable discussion. Nephron 1982; 31:321-323. (Pubitemid 12005827)
16. MacPhee PJ: Fluid uptake by the renal medullary vasa recta: an estimate based on a quantitative analysis of the distribution of fenestrae in the vasa recta of young SpragueDawley rats. Exp Physiol 1998; 83: 23-34. (Pubitemid 28048413)
17. Pallone TL, Silldorff EP: Pericyte regulation of renal medullary blood flow. Exp Nephrol 2001; 9: 165-170. (Pubitemid 32429676)
18. Bratosin D, Mitrofan L, Palii C, Estaquier J, Montreuil J: Novel fluorescence assay using calcein-AM for the determination of human erythrocyte viability and aging. Cytometry A 2005; 66:78-84. (Pubitemid 40868922)
19. Shepro D, Morel NM: Pericyte physiology. FASEB J 1993; 7:1031-1038. (Pubitemid 23243445)
20. Crawford C, Kennedy-Lydon TM, Callaghan H, Sprott C, Simmons RL, Sawbridge L, Syme HM, Unwin RJ, Wildman SS, PeppiattWildman CM: Extracellular nucleotides affect pericyte-mediated regulation of rat in situ vasa recta diameter. Acta Physiol (Oxf) 2011; 202: 241-251.
21. Landis EM: Factors controlling the movement of fluid through the human capillary wall. Yale J Biol Med 1933; 5:201-225.
22. Hamilton NB, Attwell D, Hall CN: Pericytemediated regulation of capillary diameter: a component of neurovascular coupling in health and disease. Front Neuroenergetics 2010; 2:pii 5.
23. Dunn KW, Sandoval RM, Kelly KJ, Dagher PC, Tanner GA, Atkinson SJ, Bacallao RL, Molitoris BA: Functional studies of the kidney of living animals using multicolor twophoton microscopy. Am J Physiol Cell Physiol 2002; 283:C905-C916. (Pubitemid 34920323)
24. Hall AM, Unwin RJ, Parker N, Duchen MR: Multiphoton imaging reveals differences in mitochondrial function between nephron segments. J Am Soc Nephrol 2009; 20:1293302.
25. Hughes S, Chan-Ling T: Characterization of smooth muscle cell and pericyte differentiation in the rat retina in vivo. Invest Ophthalmol Vis Sci 2004; 45:2795-2806. (Pubitemid 38998879)
26. Park F, Mattson DL, Roberts LA, Cowley AW Jr: Evidence for the presence of smooth muscle a-actin within pericytes of the renal medulla. Am J Physiol 1997; 273:R1742-R1748. (Pubitemid 27518127)
27. Armulik A, Genove G, Mae M, Nisancioglu MH, Wallgard E, Niaudet C, He L, Norlin J, Lindblom P, Strittmatter K, Johansson BR, Betsholtz C: Pericytes regulate the bloodbrain barrier. Nature 2010; 468:557-561.
28. Dahlstrom A, Haggendal J, Hokfelt T: The noradrenaline content of the varicosities of sympathetic adrenergic nerve terminals in the rat. Acta Physiol Scand 1966; 67:289-294.
29. Holliger C, Lemley KV, Schmitt SL, Thomas FC, Robertson CR, Jamison RL: Direct determination of vasa recta blood flow in the rat renal papilla. Circ Res 1983; 53: 401-413. (Pubitemid 13012422)
30. Zhang Z, Pallone TL: Response of descending vasa recta to luminal pressure. Am J Physiol Renal Physiol 2004; 287:F535-F542. (Pubitemid 39095969)
31. Kawamura H, Sugiyama T, Wu DM, Kobayashi M, Yamanishi S, Katsumura K, Puro DG: ATP: a vasoactive signal in the pericytecontaining microvasculature of the rat retina. J Physiol 2003; 551: 787-7 9 9.
32. Wu DM, Kawamura H, Sakagami K, Kobayashi M, Puro DG: Cholinergic regulation of pericyte-containing retinal microvessels. Am J Physiol Heart Circ Physiol 2003; 284:H2083-H2090. (Pubitemid 36622419)
33. Patzak A, Lai EY, Mrowka R, Steege A, Persson PB, Persson AE: AT1 receptors mediate angiotensin II-induced release of nitric oxide in afferent arterioles. Kidney Int 2004; 66: 1949-1958. (Pubitemid 41094319)
34. Zhang Z, Rhinehart K, Solis G, Pittner J, LeeKwon W, Welch WJ, Wilcox CS, Pallone TL: Chronic ANG II infusion increases NO generation by rat descending vasa recta. Am J Physiol Heart Circ Physiol 2005; 288:H29-H36. (Pubitemid 40023824)
35. Sprague RS, Ellsworth ML, Stephenson AH, Lonigro AJ: ATP: the red blood cell link to NO and local control of the pulmonary circulation. Am J Physiol 1996; 271:H2717-H2722.
36. Bogle RG, Coade SB, Moncada S, Pearson JD, Mann GE: Bradykinin and ATP stimulate Larginine uptake and nitric oxide release in vascular endothelial cells. Biochem Biophys Res Commun 1991; 180: 926-932.
37. 2+ signaling. Am J Physiol Heart Circ Physiol 2003; 284:H779-H789. (Pubitemid 36228223)
38. Praetorius HA, Frokiaer J, Leipziger J: Transepithelial pressure pulses induce nucleotide release in polarized MDCK cells. Am J Phy siol Renal Physiol 2005; 288:F133-F141. (Pubitemid 40038685)
39. Jans D, Srinivas SP, Waelkens E, Segal A, Lariviere E, Simaels J, Van Driessche W: Hypotonic treatment evokes biphasic ATP release across the basolateral membrane of cultured renal epithelia (A6). J Physiol 2002; 545:543-555. (Pubitemid 36004388)
40. Horiuchi T, Dietrich HH, Tsugane S, Dacey RG Jr: Analysis of purine- and pyrimidineinduced vascular responses in the isolated rat cerebral arteriole. Am J Physiol Heart Circ Physiol 2001; 280:H767-H776.
41. Dietrich HH, Kajita Y, Dacey RG Jr: Local and conducted vasomotor responses in isolated rat cerebral arterioles. Am J Physiol 1996; 271:H1109-H1116.
42. Whitehouse T, Stotz M, Taylor V, Stidwill R, Singer M: Tissue oxygen and hemodynamics in renal medulla, cortex, and corticomedullary junction during hemorrhage-reperfusion. Am J Physiol Renal Physiol 2006; 291:F647-F653. (Pubitemid 44343747)
43. O'Connor PM, Kett MM, Anderson WP, Evans RG: Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow. Am J Physiol Renal Physiol 2006; 290:F688-F694. (Pubitemid 43724971)