Gdown1: Making a link between Mediator and RNA polymerase II elongation control

Transcription

Volumn 3, Issue 4, 2012, Pages

  Li, Tiandao ^a   Price, David H ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

DSIF; Gdown1; Mediator; NELF; P TEFb; POLR2M; RNA polymerase II

Indexed keywords

DRB SENSITIVITY INDUCING FACTOR; ELONGATION FACTOR; NEGATIVE ELONGATION FACTOR; PROTEIN GDOWN1; RNA POLYMERASE II; THYROID TRANSCRIPTION FACTOR 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; POLR2M PROTEIN, HUMAN;

ARTICLE; BIOINFORMATICS; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME CONDENSATION; HUMAN; IN VIVO STUDY; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA TRANSLATION; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; TRANSLATION REGULATION; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; METABOLISM; METHODOLOGY; PHYSIOLOGY; TRANSCRIPTION ELONGATION;

ANIMALS; COMPUTATIONAL BIOLOGY; HUMANS; MODELS, BIOLOGICAL; RNA POLYMERASE II; TRANSCRIPTION ELONGATION, GENETIC;

EID: 84864083154     PISSN: 21541264     EISSN: 21541272     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Zhou Q, Li T, Price DH. RNA Polymerase II Elongation Control. Annu Rev Biochem 2012; PMID:22404626.
2. Nechaev S, Adelman K. Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation. Biochim Biophys Acta 2011; 1809:34-45; PMID:21081187.
3. Wada T, Takagi T, Yamaguchi Y, Ferdous A, Imai T, Hirose S, et al. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Genes Dev 1998; 12:343-56; PMID:9450929; http://dx.doi.org/10.1101/gad.12.3.343.
4. Yamaguchi Y, Takagi T, Wada T, Yano K, Furuya A, Sugimoto S, et al. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell 1999; 97:41-51; PMID:10199401; http://dx.doi.org/10.1016/S0092-8674(00)80713-8.
5. Renner DB, Yamaguchi Y, Wada T, Handa H, Price DH. A highly purified RNA polymerase II elongation control system. J Biol Chem 2001; 276:42601-9; PMID:11553615; http://dx.doi.org/10.1074/jbc.M104967200.
6. Cheng B, Price DH. Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation. J Biol Chem 2007; 282:21901-12; PMID:17548348; http://dx.doi.org/10.1074/jbc.M702936200.
7. Gilchrist DA, Nechaev S, Lee C, Ghosh SK, Collins JB, Li L, et al. NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev 2008; 22:1921-33; PMID:18628398; http://dx.doi.org/10.1101/gad.1643208.
8. Rahl PB, Lin CY, Seila AC, Flynn RA, McCuine S, Burge CB, et al. c-Myc regulates transcriptional pause release. Cell 2010; 141:432-45; PMID:20434984; http://dx.doi.org/10.1016/j.cell.2010.03.030.
9. Singh J, Padgett RA. Rates of in situ transcription and splicing in large human genes. Nat Struct Mol Biol 2009; 16:1128-33; PMID:19820712; http://dx.doi.org/10.1038/nsmb.1666.
10. Hu X, Malik S, Negroiu CC, Hubbard K, Velalar CN, Hampton B, et al. A Mediator-responsive form of metazoan RNA polymerase II. Proc Natl Acad Sci USA 2006; 103:9506-11; PMID:16769904; http://dx.doi.org/10.1073/pnas.0603702103.
11. Roginski RS, Mohan Raj BK, Birditt B, Rowen L. The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes. Genomics 2004; 84:265-76; PMID:15233991; http://dx.doi.org/10.1016/j.ygeno.2004.04.004.
12. Cheng B, Li T, Rahl PB, Adamson TE, Loudas NB, Guo J, et al. Functional association of Gdown1 with RNA polymerase II poised on human genes. Mol Cell 2012; 45:38-50; PMID:22244331; http://dx.doi.org/10.1016/j.molcel.2011.10.022.
13. Jishage M, Malik S, Wagner U, Uberheide B, Ishihama Y, Hu X, et al. Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II. Mol Cell 2012; 45:51-63; PMID:22244332; http://dx.doi.org/10.1016/j.molcel.2011.12.014.
14. Taatjes DJ. The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci 2010; 35:315-22; PMID:20299225; http://dx.doi.org/10.1016/j.tibs.2010.02.004.
15. Conaway RC, Conaway JW. Function and regulation of the Mediator complex. Curr Opin Genet Dev 2011; 21:225-30; PMID:21330129; http://dx.doi.org/10.1016/j.gde.2011.01.013.
16. Jiang Y, Liu M, Spencer CA, Price DH. Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. Mol Cell 2004; 14:375-85; PMID:15125840; http://dx.doi.org/10.1016/S1097-2765(04)00234-5.
17. Espinosa JM. Get back TFIIF, don't let me Gdown1. Mol Cell 2012; 45:3-5; PMID:22244325; http://dx.doi.org/10.1016/j.molcel.2011.12.016.
18. Seila AC, Core LJ, Lis JT, Sharp PA. Divergent transcription: a new feature of active promoters. Cell Cycle 2009; 8:2557-64; PMID:19597342; http://dx.doi.org/10.4161/cc.8.16.9305.
19. Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature 2010; 467:430-5; PMID:20720539; http://dx.doi.org/10.1038/nature09380.
20. Sun J, Pan H, Lei C, Yuan B, Nair SJ, April C, et al. Genetic and genomic analyses of RNA polymerase II-pausing factor in regulation of mammalian transcription and cell growth. J Biol Chem 2011; 286:36248-57; PMID:21865163; http://dx.doi.org/10.1074/jbc.M111.269167.
21. Čabart P, Újvári A, Pal M, Luse DS. Transcription factor TFIIF is not required for initiation by RNA polymerase II, but it is essential to stabilize transcription factor TFIIB in early elongation complexes. Proc Natl Acad Sci USA 2011; 108:15786-91; PMID:21896726; http://dx.doi.org/10.1073/pnas.1104591108.
22. Gilchrist DA, Adelman K. Coupling polymerase pausing and chromatin landscapes for precise regulation of transcription. Biochim Biophys Acta 2012; PMID:22406341.
23. Chopra VS, Cande J, Hong JW, Levine M. Stalled Hox promoters as chromosomal boundaries. Genes Dev 2009; 23:1505-9; PMID:19515973; http://dx.doi.org/10.1101/gad.1807309.
24. Wang G, Balamotis MA, Stevens JL, Yamaguchi Y, Handa H, Berk AJ. Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol Cell 2005; 17:683-94; PMID:15749018; http://dx.doi.org/10.1016/j.molcel.2005.02.010.
25. Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol 2010; 17:194-201; PMID:20098423; http://dx.doi.org/10.1038/nsmb.1752.
26. Meyer KD, Lin SC, Bernecky C, Gao Y, Taatjes DJ. p53 activates transcription by directing structural shifts in Mediator. Nat Struct Mol Biol 2010; 17:753-60; PMID:20453859; http://dx.doi.org/10.1038/nsmb.1816.
27. Takahashi H, Parmely TJ, Sato S, Tomomori-Sato C, Banks CA, Kong SE, et al. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell 2011; 146:92-104; PMID:21729782; http://dx.doi.org/10.1016/j.cell.2011.06.005.