Physical activity in multiple sclerosis: A comparative study of vitamin D, brain-derived neurotrophic factor and regulatory T cell populations

European Neurology

Volumn 68, Issue 2, 2012, Pages 122-128

  Waschbisch, A ^a   Wenny, I ^a   Tallner, A ^b   Schwab, S ^a   Pfeifer, K ^b   Maurer M ^a,c  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c CARITAS KRANKENHAUS   (Germany)

Author keywords

Brain derived neurotrophic factor; Cardiorespiratory fitness; Exercise; Foxp3; HLA G; Multiple sclerosis; Sport; Vitamin D

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; VITAMIN D;

ARTICLE; B LYMPHOCYTE; CELL POPULATION; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; ERGOMETRY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MONOCYTE; MULTIPLE SCLEROSIS; NATURAL KILLER CELL; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; VITAMIN BLOOD LEVEL;

ADULT; B-LYMPHOCYTES; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION; COHORT STUDIES; EXERCISE; EXERCISE TEST; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; PHYSICAL FITNESS; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; THIRD VENTRICLE; VITAMIN D;

EID: 84864080220     PISSN: 00143022     EISSN: 14219913     Source Type: Journal    
DOI: 10.1159/000337904     Document Type: Article

References (38)

1. Motl RW, Gosney JL: Effect of exercise training on quality of life in multiple sclerosis: a meta-analysis. Mult Scler 2008; 14: 129-135. (Pubitemid 351541406)
2. Rasova K, Havrdova E, Brandejsky P, Zalisova M, Foubikova B, Martinkova P: Comparison of the influence of different rehabilitation programmes on clinical, spirometric and spiroergometric parameters in patients with multiple sclerosis. Mult Scler 2006; 12: 227-234.
3. Andreasen AK, Stenager E, Dalgas U: The effect of exercise therapy on fatigue in multiple sclerosis. Mult Scler 2011; 17: 1041-1054.
4. Motl RW, Sandroff BM, Benedict RH: Cognitive dysfunction and multiple sclerosis: developing a rationale for considering the efficacy of exercise training. Mult Scler 2011; 17: 1034-1040.
5. Motl RW, McAuley E, Snook EM: Physical activity and multiple sclerosis: a meta-analysis. Mult Scler 2005; 11: 459-463. (Pubitemid 40984242)
6. Tallner A, Waschbisch A, Wenny I, Schwab S, Hentschke C, Pfeifer K, Maurer M: Multiple sclerosis relapses are not associated with exercise. Mult Scler 2012; 18: 232-235.
7. Gold SM, Schulz KH, Hartmann S, Mladek M, Lang UE, Hellweg R, Reer R, Braumann KM, Heesen C: Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls. J Neuroimmunol 2003; 138: 99-105. (Pubitemid 36566423)
8. Nieman DC: Special feature for the Olympics: effects of exercise on the immune system: exercise effects on systemic immunity. Immunol Cell Biol 2000; 78: 496-501.
9. Calabrese P, Kalbe E, Kessler J: Das Multiple Sklerose Inventarium Cognition (MUSIC). NeuroPsycho 2004; 30: 384-388.
10. National Multiple Sclerosis Society: http://www.nationalmssociety.org/ forprofessionals/researchers/clinical-study-measures/pasat/download.Aspx?Id=259.
11. Wagner P, Singer R: Ein Fragebogen zur Erfassung der habituellen körperlichen Aktivität verschiedener Bevölkerungsgruppen. Sportwissenschaft 2003; 33: 383-397.
12. Baecke JA, Burema J, Frijters JE: A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 1982; 36: 936-942. (Pubitemid 13214364)
13. Berg D, Maurer M, Warmuth-Metz M, Rieckmann P, Becker G: The correlation between ventricular diameter measured by transcranial sonography and clinical disability and cognitive dysfunction in patients with multiple sclerosis. Arch Neurol 2000; 57: 1289-1292.
14. American College of Sports Medicine: ACSM's Guidelines for Exercise Testing and Prescription. Baltimore, Md., Lippincott, Williams and Wilkins, 2006.
15. Knaepen K, Goekint M, Heyman EM, Meeusen R: Neuroplasticity-exercise- induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects. Sports Med 2010; 40: 765-801.
16. Snook EM, Motl RW, Gliottoni RC: The effect of walking mobility on the measurement of physical activity using accelerometry in multiple sclerosis. Clin Rehabil 2009; 23: 248-258.
17. van Poppel MN, Chinapaw MJ, Mokkink LB, van Mechelen W, Terwee CB: Physical activity questionnaires for adults: a systematic review of measurement properties. Sports Med 2010; 40: 565-600.
18. Mostert S, Kesselring J: Effects of a shortterm exercise training program on aerobic fitness, fatigue, health perception and activity level of subjects with multiple sclerosis. Mult Scler 2002; 8: 161-168. (Pubitemid 34256754)
19. Motl RW, Goldman M: Physical inactivity, neurological disability, and cardiorespiratory fitness in multiple sclerosis. Acta Neurol Scand 2011; 123: 98-104.
20. Romberg A, Virtanen A, Aunola S, Karppi SL, Karanko H, Ruutiainen J: Exercise capacity, disability and leisure physical activity of subjects with multiple sclerosis. Mult Scler 2004; 10: 212-218. (Pubitemid 38499916)
21. Heyn P, Abreu BC, Ottenbacher KJ: The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil 2004; 85: 1694-1704. (Pubitemid 39349417)
22. Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA, Welsh-Bohmer K, Browndyke JN, Sherwood A: Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med 2010; 72: 239-252.
23. Prakash RS, Snook EM, Erickson KI, Colcombe SJ, Voss MW, Motl RW, Kramer AF: Cardiorespiratory fitness: a predictor of cortical plasticity in multiple sclerosis. Neuroimage 2007; 34: 1238-1244. (Pubitemid 46068590)
24. Prakash RS, Snook EM, Motl RW, Kramer AF: Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis. Brain Res 2010; 1341: 41-51.
25. Walter U, Horowski S, Benecke R, Zettl UK: Transcranial brain sonography findings related to neuropsychological impairment in multiple sclerosis. J Neurol 2007; 254 (suppl 2):II49-II52.
26. Yoshimura S, Ochi H, Isobe N, Matsushita T, Motomura K, Matsuoka T, Minohara M, Kira J: Altered production of brain-derived neurotrophic factor by peripheral blood immune cells in multiple sclerosis. Mult Scler 2010; 16: 1178-1188.
27. Azoulay D, Vachapova V, Shihman B, Miler A, Karni A: Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: reversal by glatiramer acetate. J Neuroimmunol 2005; 167: 215-218. (Pubitemid 41242305)
28. Castellano V, White LJ: Serum brain-derived neurotrophic factor response to aerobic exercise in multiple sclerosis. J Neurol Sci 2008; 269: 85-91.
29. Yeh SH, Chuang H, Lin LW, Hsiao CY, Eng HL: Regular Tai Chi Chuan exercise enhances functional mobility and CD4CD25 regulatory T cells. Br J Sports Med 2006; 40: 239-243. (Pubitemid 43384741)
30. Yeh SH, Chuang H, Lin LW, Hsiao CY, Wang PW, Yang KD: Tai Chi Chuan exercise decreases A1C levels along with increase of regulatory T-cells and decrease of cytotoxic Tcell population in type 2 diabetic patients. Diabetes Care 2007; 30: 716-718. (Pubitemid 46354359)
31. Lowder T, Dugger K, Deshane J, Estell K, Schwiebert LM: Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma model. Brain Behav Immun 2010; 24: 153-159.
32. Feger U, Tolosa E, Huang YH, Waschbisch A, Biedermann T, Melms A, Wiendl H: HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation. Blood 2007; 110: 568-577. (Pubitemid 47105395)
33. Korporal M, Haas J, Balint B, Fritzsching B, Schwarz A, Moeller S, Fritz B, Suri-Payer E, Wildemann B: Interferon beta-induced restoration of regulatory T-cell function in multiple sclerosis is prompted by an increase in newly generated naive regulatory T cells. Arch Neurol 2008; 65: 1434-1439.
34. Azoulay D, Mausner-Fainberg K, Urshansky N, Fahoum F, Karni A: Interferon-beta therapy up-regulates BDNF secretion from PBMCs of MS patients through a CD40-dependent mechanism. J Neuroimmunol 2009; 211: 114-119.
35. Lalive PH, Kantengwa S, Benkhoucha M, Juillard C, Chofflon M: Interferon-beta induces brain-derived neurotrophic factor in peripheral blood mononuclear cells of multiple sclerosis patients. J Neuroimmunol 2008; 197: 147-151.
36. Ascherio A, Munger KL, Simon KC: Vitamin D and multiple sclerosis. Lancet Neurol 2010; 9: 599-612.
37. Absoud M, Cummins C, Lim MJ, Wassmer E, Shaw N: Prevalence and predictors of vitamin D insufficiency in children: A Great Britain population based study. PLoS One 2011; 6:e22179.
38. Farrell SW, Willis BL: Cardiorespiratory fitness, adiposity, and serum 25-dihydroxyvitamin D levels in women: the Cooper Center Longitudinal Study. J Womens Health 2012; 21: 80-86.