Wound care: Biofilm and its impact on the latest treatment modalities for ulcerations of the diabetic foot

Seminars in Vascular Surgery

Volumn 25, Issue 2, 2012, Pages 70-74

  Kim, Paul J ^a   Steinberg, John S ^a  

^a GEORGETOWN UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CADEXOMER IODINE; GENTAMICIN; MEDICINAL HONEY; NATURAL PRODUCT; OXYGEN; PEXIGANAN; POLYSPORIN; SULFADIAZINE SILVER; UNCLASSIFIED DRUG;

ARTICLE; BIOFILM; BIONGINEERED ALTERNATIVE TISSUE; CHRONIC WOUND; DEBRIDEMENT; DIABETIC FOOT; HUMAN; HYPERBARIC OXYGEN; PRIORITY JOURNAL; SOFT TISSUE INJURY; TISSUE ENGINEERING; TREATMENT PLANNING; ULTRASOUND THERAPY; VACUUM ASSISTED CLOSURE; WOUND CARE; WOUND CLOSURE; WOUND INFECTION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFECTIVE AGENTS; BIOFILMS; COMBINED MODALITY THERAPY; DEBRIDEMENT; DIABETIC FOOT; HUMANS; HYPERBARIC OXYGENATION; NEGATIVE-PRESSURE WOUND THERAPY; TISSUE ENGINEERING; TREATMENT OUTCOME; ULTRASONIC THERAPY; WOUND CLOSURE TECHNIQUES; WOUND HEALING; WOUND INFECTION;

EID: 84864057026     PISSN: 08957967     EISSN: 15584518     Source Type: Journal    
DOI: 10.1053/j.semvascsurg.2012.04.008     Document Type: Article

References (70)

1. Davis S.C., Ricotti C., Cazzaniga A., et al. Microscopic and physiologic evidence for biofilm-associated wound colonization in vivo. Wound Repair Regen 2008, 16:23-29.
2. Ha K.R., Psaltis A.J., Butcher A.R., et al. In vitro activity of mupirocin on clinical isolates of Staphylococcus aureus and its potential implications in chronic rhinosinusitis. Laryngoscope 2008, 118:535-540.
3. Hill K.E., Malic S., McKee R., et al. An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities. J Antimicrob Chemother 2010, 65:1195-1206.
4. Stewart P.S., Costerton J.W. Antibiotic resistance of bacteria in biofilms. Lancet 2001, 358(9276):135-138.
5. Hoiby N., Bjarnsholt T., Givskov M., et al. Antibiotic resistance of bacterial biofilms. Int J Antimicrob Agents 2010, 35:322-332.
6. Han A., Zenilman J.M., Melendez J.H., et al. The importance of a multifaceted approach to characterizing the microbial flora of chronic wounds. Wound Repair Regen 2011, 19:532-541.
7. Howell-Jones R.S., Wilson M.J., Hill K.E., et al. A review of the microbiology, antibiotic usage and resistance in chronic skin wounds. J Antimicrob Chemother 2005, 55:143-149.
8. Frank D.N., Wysocki A., Specht-Glick D.D., et al. Microbial diversity in chronic open wounds. Wound Repair Regen 2009, 17:163-172.
9. Dowd S.E., Sun Y., Secor P.R., et al. Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing. BMC Microbiol 2008, 8:43.
10. Melendez J.H., Frankel Y.M., An A.T., et al. Real-time PCR assays compared to culture-based approaches for identification of aerobic bacteria in chronic wounds. Clin Microbiol Infect 2010, 16:1762-1769.
11. Costerton J.W., Stewart P.S., Greenberg E.P. Bacterial biofilms: a common cause of persistent infections. Science 1999, 284(5418):1318-1322.
12. Harrison-Balestra C., Cazzaniga A.L., Davis S.C., et al. A wound-isolated Pseudomonas aeruginosa grows a biofilm in vitro within 10 hours and is visualized by light microscopy. Dermatol Surg 2003, 29:631-635.
13. James G.A., Swogger E., Wolcott R., et al. Biofilms in chronic wounds. Wound Repair Regen 2008, 16:37-44.
14. Zhao G., Hochwalt P.C., Usui M.L., et al. Delayed wound healing in diabetic (db/db) mice with Pseudomonas aeruginosa biofilm challenge: a model for the study of chronic wounds. Wound Repair Regen 2010, 18:467-477.
15. Wolcott R.D., Rhoads D.D. A study of biofilm-based wound management in subjects with critical limb ischaemia. J Wound Care 2008, 17:145-148. 150-152, 154-155.
16. Davis S.C., Martinez L., Kirsner R. The diabetic foot: the importance of biofilms and wound bed preparation. Curr Diab Rep 2006, 6:439-445.
17. Bowler P.G., Duerden B.I., Armstrong D.G. Wound microbiology and associated approaches to wound management. Clin Microbiol Rev 2001, 14:244-269.
18. Cardinal M., Eisenbud D.E., Armstrong D.G., et al. Serial surgical debridement: a retrospective study on clinical outcomes in chronic lower extremity wounds. Wound Repair Regen 2009, 17:306-311.
19. Steed D.L., Donohoe D., Webster M.W., et al. Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. Diabetic Ulcer Study Group. J Am Coll Surg 1996, 183:61-64.
20. Piaggesi A., Schipani E., Campi F., et al. Conservative surgical approach versus non-surgical management for diabetic neuropathic foot ulcers: a randomized trial. Diabet Med 1998, 15:412-417.
21. Saap L.J., Falanga V. Debridement performance index and its correlation with complete closure of diabetic foot ulcers. Wound Repair Regen 2002, 10:354-359.
22. Kingsley A., Lewis T., White R. Debridement and wound biofilms. J Wound Care 2011, 20:286.
23. Cornell R.S., Meyr A.J., Steinberg J.S., et al. Debridement of the noninfected wound. J Vasc Surg 2010, 52(suppl):31S-36S.
24. Wolcott R.D., Rumbaugh K.P., James G., et al. Biofilm maturity studies indicate sharp debridement opens a time-dependent therapeutic window. J Wound Care 2010, 19:320-328.
25. Gravante G., Delogu D., Esposito G., et al. Versajet hydrosurgery versus classic escharectomy for burn debridment: a prospective randomized trial. J Burn Care Res 2007, 28:720-724.
26. Caputo W.J., Beggs D.J., DeFede J.L., et al. A prospective randomised controlled clinical trial comparing hydrosurgery debridement with conventional surgical debridement in lower extremity ulcers. Int Wound J 2008, 5:288-294.
27. Kavros S.J., Miller J.L., Hanna S.W. Treatment of ischemic wounds with noncontact, low-frequency ultrasound: the Mayo clinic experience, 2004-2006. Adv Skin Wound Care 2007, 20:221-226.
28. Breuing K.H., Bayer L., Neuwalder J., et al. Early experience using low-frequency ultrasound in chronic wounds. Ann Plast Surg 2005, 55:183-187.
29. Morykwas M.J., Argenta L.C., Shelton-Brown E.I., et al. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg 1997, 38:553-562.
30. Morykwas M.J., Faler B.J., Pearce D.J., et al. Effects of varying levels of subatmospheric pressure on the rate of granulation tissue formation in experimental wounds in swine. Ann Plast Surg 2001, 47:547-551.
31. Timmers M.S., Le Cessie S., Banwell P., et al. The effects of varying degrees of pressure delivered by negative-pressure wound therapy on skin perfusion. Ann Plast Surg 2005, 55:665-671.
32. Weed T., Ratliff C., Drake D.B. Quantifying bacterial bioburden during negative pressure wound therapy: does the wound VAC enhance bacterial clearance?. Ann Plast Surg 2004, 52:276-279. discussion 279-280.
33. Ngo Q.D., Vickery K., Deva A.K. The effect of topical negative pressure on wound biofilms using an in vitro wound model. Wound Repair Regen 2012, 20:83-90.
34. Hirsch T., Limoochi-Deli S., Lahmer A., et al. Antimicrobial activity of clinically used antiseptics and wound irrigating agents in combination with wound dressings. Plast Reconstr Surg 2011, 127:1539-1545.
35. Gabriel A., Shores J., Heinrich C., et al. Negative pressure wound therapy with instillation: a pilot study describing a new method for treating infected wounds. Int Wound J 2008, 5:399-413.
36. O'Meara S.M., Cullum N.A., Majid M., et al. Systematic review of antimicrobial agents used for chronic wounds. Br J Surg 2001, 88:4-21.
37. Lima A.F., Costa L.B., Silva J.L., et al. Interventions for wound healing among diabetic patients infected with Staphylococcus aureus: a systematic review. Sao Paulo Med J 2011, 129:165-170.
38. Daroczy J. Quality control in chronic wound management: the role of local povidone-iodine (Betadine) therapy. Dermatology 2006, 212(suppl 1):82-87.
39. Thorn R.M., Austin A.J., Greenman J., et al. In vitro comparison of antimicrobial activity of iodine and silver dressings against biofilms. J Wound Care 2009, 18:343-346.
40. Neely A.N., Gardner J., Durkee P., et al. Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics?. J Burn Care Res 2009, 30:19-29.
41. Percival S.L., Bowler P.G., Dolman J. Antimicrobial activity of silver-containing dressings on wound microorganisms using an in vitro biofilm model. Int Wound J 2007, 4:186-191.
42. Lund-Nielsen B., Adamsen L., Gottrup F., et al. Qualitative bacteriology in malignant wounds-a prospective, randomized, clinical study to compare the effect of honey and silver dressings. Ostomy Wound Manage 2011, 57:28-36.
43. Lipsky B.A., Holroyd K.J., Zasloff M. Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream. Clin Infect Dis 2008, 47:1537-1545.
44. Moghazy A.M., Shams M.E., Adly O.A., et al. The clinical and cost effectiveness of bee honey dressing in the treatment of diabetic foot ulcers. Diabetes Res Clin Pract 2010, 89:276-281.
45. Shukrimi A., Sulaiman A.R., Halim A.Y., et al. A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers. Med J Malaysia 2008, 63:44-46.
46. Desbois A.P., Gemmell C.G., Coote P.J. In vivo efficacy of the antimicrobial peptide ranalexin in combination with the endopeptidase lysostaphin against wound and systemic meticillin-resistant Staphylococcus aureus (MRSA) infections. Int J Antimicrob Agents 2010, 35:559-565.
47. Kessler L., Piemont Y., Ortega F., et al. Comparison of microbiological results of needle puncture vs. superficial swab in infected diabetic foot ulcer with osteomyelitis. Diabet Med 2006, 23:99-102.
48. Sharp C.S., Bessman A.N., Wagner F.W., et al. Microbiology of deep tissue in diabetic gangrene. Diabetes Care 1978, 1:289-292.
49. Sharp C.S., Bessmen A.N., Wagner F.W., et al. Microbiology of superficial and deep tissues in infected diabetic gangrene. Surg Gynecol Obstet 1979, 149:217-219.
50. Slater R.A., Lazarovitch T., Boldur I., et al. Swab cultures accurately identify bacterial pathogens in diabetic foot wounds not involving bone. Diabet Med 2004, 21:705-709.
51. Fisher T.K., Wolcott R., Wolk D.M., et al. Diabetic foot infections: a need for innovative assessments. Int J Low Extrem Wounds 2010, 9:31-36.
52. Wolcott R.D., Dowd S.E. A rapid molecular method for characterising bacterial bioburden in chronic wounds. J Wound Care 2008, 17:513-516.
53. Sun Y., Smith E., Wolcott R., et al. Propagation of anaerobic bacteria within an aerobic multi-species chronic wound biofilm model. J Wound Care 2009, 18:426-431.
54. Wolcott R.D., Cox S.B., Dowd S.E. Healing and healing rates of chronic wounds in the age of molecular pathogen diagnostics. J Wound Care 2010, 19:272-278. 280-281.
55. Dowd S.E., Wolcott R.D., Kennedy J., et al. Molecular diagnostics and personalised medicine in wound care: assessment of outcomes. J Wound Care 2011, 20:232. 234-239.
56. Percival S.L., Slone W., Linton S., et al. Use of flow cytometry to compare the antimicrobial efficacy of silver-containing wound dressings against planktonic Staphylococcus aureus and Pseudomonas aeruginosa. Wound Repair Regen 2011, 19:436-441.
57. Thomas J.G., Slone W., Linton S., et al. A comparison of the antimicrobial efficacy of two silver-containing wound dressings on burn wound isolates. J Wound Care 2011, 20:580-586.
58. Ammons M.C., Ward L.S., James G.A. Anti-biofilm efficacy of a lactoferrin/xylitol wound hydrogel used in combination with silver wound dressings. Int Wound J 2011, 8:268-273.
59. Kostenko V., Lyczak J., Turner K., et al. Impact of silver-containing wound dressings on bacterial biofilm viability and susceptibility to antibiotics during prolonged treatment. Antimicrob Agents Chemother 2010, 54:5120-5131.
60. Lipp C., Kirker K., Agostinho A., et al. Testing wound dressings using an in vitro wound model. J Wound Care 2010, 19:220-226.
61. Beele H., Meuleneire F., Nahuys M., et al. A prospective randomised open label study to evaluate the potential of a new silver alginate/carboxymethylcellulose antimicrobial wound dressing to promote wound healing. Int Wound J 2010, 7:262-270.
62. Trial C., Darbas H., Lavigne J.P., et al. Assessment of the antimicrobial effectiveness of a new silver alginate wound dressing: a RCT. J Wound Care 2010, 19:20-26.
63. Jude E.B., Apelqvist J., Spraul M., et al. Prospective randomized controlled study of Hydrofiber dressing containing ionic silver or calcium alginate dressings in non-ischaemic diabetic foot ulcers. Diabet Med 2007, 24:280-288.
64. Veves A., Falanga V., Armstrong D.G., et al. Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial. Diabetes Care 2001, 24:290-295.
65. Marston W.A., Hanft J., Norwood P., et al. The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial. Diabetes Care 2003, 26:1701-1705.
66. Iorio M.L., Goldstein J., Adams M., et al. Functional limb salvage in the diabetic patient: the use of a collagen bilayer matrix and risk factors for amputation. Plast Reconstr Surg 2011, 127:260-267.
67. Menn Z.K., Lee E., Klebuc M.J. Acellular dermal matrix and negative pressure wound therapy: a tissue-engineered alternative to free tissue transfer in the compromised host. J Reconstr Microsurg 2012, 28:139-144.
68. Fraccalvieri M., Pristera G., Zingarelli E., et al. Treatment of chronic heel osteomyelitis in vasculopathic patients. Can the combined use of Integra((R)), skin graft and negative pressure wound therapy be considered a valid therapeutic approach after partial tangential calcanectomy?. Int Wound J 2012, 9:214-220.
69. Cimsit M., Uzun G., Yildiz S. Hyperbaric oxygen therapy as an anti-infective agent. Expert Rev Anti Infect Ther 2009, 7:1015-1026.
70. Chen C.E., Ko J.Y., Fong C.Y., Juhn R.J. Treatment of diabetic foot infection with hyperbaric oxygen therapy. Foot Ankle Surg 2010, 16:91-95.