Comparative profile of vasodilation by CVT-3146, a novel A2A receptor agonist, and adenosine in conscious dogs

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 1, 2003, Pages 182-189

  Zhao, Gong ^a   Linke, Axel ^b   Xu, Xiaobin ^b   Ochoa, Manuel ^b   Belloni, Francis ^b   Belardinelli, Luiz ^a   Hintze, Thomas H ^b  

^a CV THERAPEUTICS INC   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACEPROMAZINE; ADENOSINE; ADENOSINE A2A RECEPTOR AGONIST; CORONARY VASODILATING AGENT; PENTOBARBITAL; REGADENOSON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; BOLUS INJECTION; CONSCIOUSNESS; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; CORONARY VASCULAR RESISTANCE; DIASTOLE; DOG; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; EXERCISE TEST; FEMALE; HEART OUTPUT; KIDNEY ARTERY VASOCONSTRICTION; KIDNEY BLOOD FLOW; LOWER BODY FLOW; MALE; MESENTERY BLOOD FLOW; NONHUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; VASCULAR RESISTANCE; VASOCONSTRICTION; VASODILATATION;

ADENOSINE; ANIMALS; BLOOD PRESSURE; CARDIAC OUTPUT; CORONARY CIRCULATION; CORONARY VESSELS; DOGS; HEART; HEART RATE; KIDNEY; MESENTERIC ARTERIES; PURINES; PYRAZOLES; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; VASODILATION; VASODILATOR AGENTS;

EID: 0141854148     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.053306     Document Type: Article

References (31)

1. 2A-AdoR agonists. J Cardiovasc Pharmacol 30:320-324.
2. Allison T, Bardsley WT, Behrenbeck T, Christian TF, Clements IP, Edwards BS, Gibbons RJ, Miller TD, Oh JK, Pellikka PA, et al. (1996) Cardiovascular stress testing: a description of the various types of stress tests and indications for their use. Mayo Clin Proc 71:43-52.
3. 2A adenosine receptor mediates coronary vasodilation. J Pharmacol Exp Ther 284:1066-1073.
4. Belardinelli L, Shryock JC, Song Y, Wang D, and Srinivas M (1995) Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes. FASEB J 9:359-365.
5. Belloni FL, Brown I, and Hintze TH (1989) Mechanism of the apparent parasympathetic inhibition of adenosine induced heart rate slowing in the dog. Cardiovasc Res 23:239-248.
6. Belloni FL and Hintze TH (1987) Effects of adenosine on heart rate in conscious animals: interaction between adenosine and parasympathetic mechanisms at the sinoatrial node, in Cardiac Electrophysiology and Pharmacology of Adenosine and ATP: Basic and Clinical Aspects (Pelleg A, Michelson EL, and Dreifus LS eds) pp 361-374, Alan R Liss, Inc., New York.
7. Belloni FL, Wang J, and Hintze TH (1992) Adenosine causes bradycardia in pacing-induced cardiac failure. Circulation 85:1118-1124.
8. Biaggioni I, Killian TJ, Mosqueda-Garcia R, Robertson RM, and Robertson D (1991) Adenosine increases sympsthetic nerve traffic in humans. Circulation 83:1668-1675.
9. Cerqueira MDC (2000) The role of pharmacologic stress testing for myocardial perfusion imaging. Rev Port Cardiol 19 (Suppl I):23-28.
10. Engelstein ED, Lerman BB, Somers VK, and Rea RF (1994) Role of arterial chemoreceptors in mediating the effects of endogenous adenosine on sympathetic nerve activity. Circulation 90:2919-2926.
11. Fozard JR and Hannon JP (1999) Adenosine receptor ligands: potential as therapeutic agents in asthma and COPD. Pulm Pharmacol Ther 12:111-114.
12. 2A agonists. J Pharmacol Exp Ther 298:209-218.
13. Gao Z, Rosete J, Kohler G, Huang BL, Blackburn B, and Belardinelli L (2001b) Negative chronotropic effect of CVT-510 in anesthetized and awake rats. Drug Dev Res 52:424-430.
14. 2A receptor agonist. Circulation 94:1726-1732.
15. Hintze TH, Belloni FL, Harrison JE, and Shapiro GC (1985) Apparent reduction in baroreflex sensitivity to adenosine in conscious dogs. Am J Physiol Heart Circ Physiol 249:H554-H559.
16. Hintze TH and Vatner SF (1984) Reactive dilation of large coronary arteries in conscious dogs. Circ Res 54:50-57.
17. 2A adenosine receptor agonist: a potential agent for the use in pharmacological stress testing for myocardial perfusion imaging (Abstract). Circulation 106 (Suppl II):11-618.
18. Leppo JA (1996) Comparison of pharmacologic stress agents. J Nucl Cardiol 3:S22-S26.
19. Liang IYS and Stone HL (1982) Effect of exercise conditioning on coronary resistance. J Appl Physiol 53:631-636.
20. Lucarini AR, Picano E, Marini C, Favilla S, Savetti A, and Distante A (1992) Activation of sympathetic tone during dipyridamole test. Chest 102:444-447.
21. 2B receptors in human skeletal muscle. Acta Physiol Scand 169:283-290.
22. Mahmarian JJ and Verani MS (1994) Myocardial perfusion imaging during pharmacologic stress testing. Cardiol Clin 12:223-245.
23. Marwick TH (1997) Adenosine echocardiography in the diagnosis of coronary artery disease. Eur Heart J 18:D31-D36.
24. McCoy DE, Bhattacharya ES, Olson BA Levier DC, Arend LJ, and Spielman WS (1993) The renal adenosine system: structure, function and regulation. Semin Nephrol 13:31-40.
25. McGuinness ME and Talbert RL (1994) Pharmacologic stress testing: experience with dipyridamole, adenosine and dobutamine. Am J Hosp Pharm 51:328-405.
26. 2B receptors. Am J Physiol Heart Circ Physiol 282:H437-H444.
27. Pelueger AC, Osswald H, and Knox FG (1999) Adenosine-induced renal vasoconstriction in diabetes mellitus rats: role of nitric oxide. Am J Physiol Renal Physiol 276:F340-F346.
28. Shryock JC and Belardinelli L (1997) Adenosine and AdoR in the cardiovascular system: biochemistry, physiology and pharmacology. Am J Cardiol 79:2-10.
29. 2A-adenosine receptor reserve for coronary vasodilation. Circulation 98:711-718.
30. Talukder MAH, Morrison RR, and Mustafa SJ (2002) Comparison of the vascular effects of adenosine in isolated mouse heart and aorta. Am J Physiol Heart Circ Physiol 282:H49-H51.
31. 2A adenosine receptor agonist as a coronary vasodilator in conscious dogs: potential for use in myocardial perfusion imaging. J Cardiovasc Pharmacol 41:132-139.