Polymersomes as nano-carriers to retain harmful recoil nuclides in alpha radionuclide therapy: A feasibility study

Radiochimica Acta

Volumn 100, Issue 7, 2012, Pages 473-481

  Thijssen, L ^a   Schaart, D R ^a   De Vries, D ^a   Morgenstern, A ^b   Bruchertseifer, F ^b   Denkova, A G ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b JOINT RESEARCH CENTRE   (Italy)

Author keywords

Alpha radionuclide therapy; Polymersomes; Recoil retention

Indexed keywords

EID: 84864049430     PISSN: 00338230     EISSN: None     Source Type: Journal    
DOI: 10.1524/ract.2012.1935     Document Type: Article

References (22)

1. Mulford, D. A. Scheinberg, D. A., Jurcic, J. G.: The promise of targeted alpha-particle therapy. J. Nucl. Med. 46(Suppl. 1), 199S (2005).
2. Morgenstern, A., Bruchertseifer, F., Apostolidis, C.: Targeted alpha therapy with 213 Bi. Curr. Radiopharm. 4, 295 (2011).
3. Jurcic, J. G., Larson, S. M., Sgouros, G., McDevitt, M. R., Finn, R. D., Divgi, C. R., Ballangrud, A. M., Hamacher, K. A., Ma, D., Humm, J. L., Brechbiel, M. W., Molinet, R., Scheinberg, D. A.: Targeted alpha particle immunotherapy for myeloid leukemia. Blood 100, 1233 (2002).
4. Rosenblat, T. L., McDevitt, M. R., Mulford, D. A., Pandit-Taskar, N., Divgi, C. R. Panageas, K. S. Heaney, M. L., Chanel, S., Morgenstern, A., Sgouros, G., Larson, S. M., Scheinberg, D. A., Jurcic, J. G.: Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia. Clin. Cancer Res. 16, 5303 (2010).
5. th Alpha-Immunotherapy Symposium, Düsseldorf, Germany, 28-29 June 2004. (Morgenstern, A., ed.) Institute for Transuranium Elements, Karlsruhe, Germany (2004), p. 11.
6. Allen, B. J., Raja, C., Rizvi, S., Li, Y., Tsui, W., Graham, P., Thompson, F., Reisfeld, R. A., Kearsley, J., Morgenstern, A., Apostolidis, C.: Intralesional targeted alpha therapy for metastatic melanoma. Cancer Biol. Ther. 4, 1318 (2005).
7. Raja, C., Graham, V., Abbas Rizvi, S. M., Song, E., Goldsmith, H., Thompson, J., Bosserhoff, A., Morgenstern, A., Apostolidis, C., Kearsley, J., Reisfeld, R. A., Allen, B. J.: Interim analysis of toxicity and response in Phase 1 trial of systemic targeted alpha therapy for metastatic melanoma. Cancer Biol. Ther. 6, 846 (2007).
8. Kneifel, S., Cordier, D., Good, S., Ionescu, M. C., Ghaffari, A., Hofer, S., Kretzschmar, M., Tolnay, M., Apostolidis, C., Waser, B., Arnold, M., Mueller-Brand, J., Maecke, H. R., Reubi, J. C., Merlo, A.: Local targeting of malignant gliomas by the diffusible peptidic vector 1, 4, 7, 10-tetraazacyclododecane-1-glutaricacid-4, 7, 10-triacetic acid-substance p. Clin. Cancer Res. 12, 3843 (2006).
9. Cordier, D., Forrer, F., Bruchertseifer, F., Morgenstern, A., Apostolidis, C., Good, S., Mueller-Brand, J., Maecke, H., Reubi, J. C., Merlo, A.: Targeted alpha-radionuclide therapy of functionally critically located gliomas with (213) Bi-DOTA-[Thi (8), Met (O (2)) (11)]-substance P: a pilot trial. Eur. J. Nucl. Med. Mol. Imaging 37, 1335 (2010).
10. 90Y. Cancer Res. 69, 8941 (2009).
11. Noguchi, Y., Wu, J., Duncan, R., Strohalm, J., Ulbrich, K., Akaike, T., Maeda, H.: Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues. Jpn. J. Cancer Res. 89, 307 (1998).
12. Sofou, S., Thomas, J. L., Hung-yin, L. McDevitt, M. R., Scheinberg, D. A., Sgouros, G.: Engineered liposomes for potential α-particle therapy of metastatic cancer. J. Nucl. Med. 45, 253, (2004).
13. 225 Ac in rigid liposomes for potential targeted therapy of micrometastases. Bioconjug. Chem. 19, 1274 (2008).
14. Opsteen, J. A., Cornelissen, J. J. L. M., van Hest, J. C. M.: Block copolymer vesicles. Pure Appl. Chem. 76, 1309 (2004).
15. McDevitt, M. R., Ma, D., Lai, L. T., Simon, J., Borchardt, P., Frank, R. K., Wu, K., Pellegrini, V., Curcio, M. J., Miederer, M., Bander, N. H., Scheinberg, D. A.: Tumor therapy with targeted atomic nanogenerators. Science 294, 1537 (2010).
16. http://www.srim.org/.
17. Ziegler, J. F., Biersack, J. P., Littmark, U.: In: The Stopping and Range of Ions in Matter. Vol. 1, Pergamon Press, New York (1985).
18. Agostinelli, S., et al.: GEANT4: a simulation toolkit. Nucl. Instrum. Methods A 506, 250 (2003).
19. Apostolidis, C., Molinet, R., Rasmussen, G., Morgenstern, A.: Production of Ac-225 from Th-229 for targeted alpha therapy. Anal. Chem. 77, 6288 (2005).
20. Zielinska, B., Apostolidis, C., Bruchertseifer, F., Morgenstern, A.: An improved method for the production of Ac-225/Bi-213 from Th-229 for targeted alpha therapy. Solvent Extr. Ion Exch. 25, 339 (2007).
21. 225 actinium chelates: tissue distribution and radiotoxicity. Nucl. Med. Biol. 26, 581, (1999).
22. th edn. (Kugler, H. K., Keller, C., eds.) Springer-Verlag, New York (1981), p. 181.