Deep intron elements mediate nested splicing events at consecutive ag dinucleotides to regulate alternative 3' splice site choice in vertebrate 4.1 genes

Molecular and Cellular Biology

Volumn 32, Issue 11, 2012, Pages 2044-2053

  Parra, Marilyn K ^a   Gallagher, Thomas L ^b   Amacher, Sharon L ^b   Mohandas, Narla ^c   Conboy, John G ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NEW YORK BLOOD CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DINUCLEOTIDE; MESSENGER RNA PRECURSOR; MORPHOLINO OLIGONUCLEOTIDE;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELLIPTOCYTOSIS; EMBRYO; EXON; GENE CONTROL; GENETIC ANALYSIS; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VIVO CULTURE; INTRON; MOUSE; NONHUMAN; PARALOGY; PRIORITY JOURNAL; REPORTER GENE; VERTEBRATE; ZEBRA FISH;

ALTERNATIVE SPLICING; ANIMALS; HUMANS; INTRONS; MICE; MICROFILAMENT PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; RNA PRECURSORS; RNA SPLICE SITES;

ANIMALIA; DANIO RERIO; VERTEBRATA;

EID: 84864023850     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.05716-11     Document Type: Article

References (31)

1. Auboeuf D, Batsche E, Dutertre M, Muchardt C, O'Malley BW. 2007. Coregulators: transducing signal from transcription to alternative splicing. Trends Endocrinol. Metab. 18:122-129.
2. Baek D, Davis C, Ewing B, Gordon D, Green P. 2007. Characterization and predictive discovery of evolutionarily conserved mammalian alternative promoters. Genome Res. 17:145-155.
3. Baklouti F, et al. 1997. Organization of the human protein 4.1 genomic locus: new insights into the tissue-specific alternative splicing of the premRNA. Genomics 39:289-302.
4. Baklouti F, et al. 2011. Homozygous deletion of EPB41 genuine AUGcontaining exons results in mRNA splicing defects, NMD activation and protein 4.1R complete deficiency in hereditary elliptocytosis. Blood Cells Mol. Dis. 47:158-165.
5. Burnette JM, Miyamoto-Sato E, Schaub MA, Conklin J, Lopez AJ. 2005.Subdivision of large introns in Drosophila by recursive splicing at nonexonic elements. Genetics 170:661-674.
6. Cavanna T, Pokorna E, Vesely P, Gray C, Zicha D. 2007. Evidence for protein 4.1B acting as a metastasis suppressor. J. Cell Sci. 120:606-616.
7. Conboy J. 1999. The role of alternative pre-mRNA splicing in regulating the structure and function of skeletal protein 4.1. Proc. Soc. Exp. Biol. Med. 220:73-78.
8. Crabb TL, Lam BJ, Hertel KJ. 2010. Retention of spliceosomal components along ligated exons ensures efficient removal of multiple introns. RNA 16:1786-1796.
9. Fu XD, Mayeda A, Maniatis T, Krainer AR. 1992. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc. Natl. Acad. Sci. U. S. A. 89:11224-11228.
10. Gao K, Masuda A, Matsuura T, Ohno K. 2008. Human branch point consensus sequence is yUnAy. Nucleic Acids Res. 36:2257-2267.
11. Gascard P, et al. 2004. Putative tumor suppressor protein 4.1B is differentially expressed in kidney and brain via alternative promoters and 5' alternative splicing. Biochim. Biophys. Acta 1680:71-82.
12. Gerber MA, Bahr SM, Gutmann DH. 2006. Protein 4.1B/differentially expressed in adenocarcinoma of the lung-1 functions as a growth suppressor in meningioma cells by activating Rac1-dependent c-Jun-NH(2)-kinase signaling. Cancer Res. 66:5295-5303.
13. Horresh I, Bar V, Kissil JL, Peles E. 2010. Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B. J. Neurosci. 30:2480-2489.
14. Hoy JL, Constable JR, Vicini S, Fu Z, Washbourne P. 2009. SynCAM1 recruitsNMDAreceptors via protein 4.1B. Mol. Cell. Neurosci. 42:466-483.
15. Huang SC, et al. 2009. Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R gene. Blood 114:4233-4242.
16. Jung Y, Kissil JL, McCarty JH. 2011. _8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart. Dev. Dyn. 240: 271-277.
17. Kang Q, Wang T, Zhang H, Mohandas N, An X. 2009. A Golgiassociated protein 4.1B variant is required for assimilation of proteins in the membrane. J. Cell Sci. 122:1091-1099.
18. Kimura K, et al. 2006. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome Res. 16:55-65.
19. Kornblihtt AR. 2005. Promoter usage and alternative splicing. Curr. Opin. Cell Biol. 17:262-268.
20. McCarty JH, Cook AA, Hynes RO. 2005. An interaction between αvβ8 integrin and band 4.1B via a highly conserved region of the band 4.1 C-terminal domain. Proc. Natl. Acad. Sci. U. S. A. 102:13479-13483.
21. Morcos PA, Li Y, Jiang S. 2008. Vivo-morpholinos: a non-peptide transporter delivers morpholinos into a wide array of mouse tissues. Biotechniques 45:613-623.
22. Nilsen TW, Graveley BR. 2010. Expansion of the eukaryotic proteome by alternative splicing. Nature 463:457-463.
23. Nunomura W, et al. 2009. Marked difference in membrane-proteinbinding properties of the two isoforms of protein 4.1R expressed at early and late stages of erythroid differentiation. Biochem. J. 417:141-148.
24. Ott S, Tamada Y, Bannai H, Nakai K, Miyano S. 2003. Intrasplicing- analysis of long intron sequences. Pac. Symp. Biocomput. 2003:339-350.
25. Parra M, Tan JS, Mohandas N, Conboy JG. 2008. Intrasplicing coordinates alternative first exons with alternative splicing in the protein 4.1R gene. EMBO J. 27:122-131.
26. Parra MK, Gee S, Mohandas N, Conboy JG. 2011. Efficient in vivo manipulation of alternative pre-mRNA splicing events using antisense morpholinos in mice. J. Biol. Chem. 286:6033-6039.
27. Robb VA, Gerber MA, Hart-Mahon EK, Gutmann DH. 2005. Membrane localization of the U2 domain of protein 4.1B is necessary and sufficient for meningioma growth suppression. Oncogene 24:1946-1957.
28. Tan JS, Mohandas N, Conboy JG. 2005. Evolutionarily conserved coupling of transcription and alternative splicing in the EPB41 (protein 4.1R) and EPB41L3 (protein 4.1B) genes. Genomics 86:701-707.
29. Vogel J, Hess WR, Borner T. 1997. Precise branch point mapping and quantification of splicing intermediates. Nucleic Acids Res. 25:2030-2031.
30. Wong SY, et al. 2007. Protein 4.1B suppresses prostate cancer progression and metastasis. Proc. Natl. Acad. Sci. U. S. A. 104:12783-12789.
31. Zammarchi F, et al. 2011. Antitumorigenic potential of STAT3 alternative splicing modulation. Proc. Natl. Acad. Sci. U. S. A. 108:17779-17784.