Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: Insights into pyridoxal kinase inhibition

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Gandhi, Amit K ^a   Desai, Jigar V ^a   Ghatge, Mohini S ^a   di Salvo, Martino L ^b   Di Biase, Stefano ^b,c   Danso Danquah, Richmond ^a   Musayev, Faik N ^a   Contestabile, Roberto ^b   Schirch, Verne ^a   Safo, Martin K ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; ENPROFYLLINE; GINKGOTOXIN; LAMOTRIGINE; NEUROTOXIN; PYRIDOXAL KINASE; THEOBROMINE; THEOPHYLLINE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS;

CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; NEUROTOXINS; PYRIDOXAL KINASE; PYRIDOXINE; THEOPHYLLINE;

EID: 84864013068     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040954     Document Type: Article

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