Merkel cell carcinoma induces lymphatic microvessel formation

Journal of the American Academy of Dermatology

Volumn 67, Issue 2, 2012, Pages 215-225

  Werchau, Siegfried ^a   Toberer, Ferdinand ^a   Enk, Alexander ^a   Dammann, Reinhard ^b   Helmbold, Peter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

lymphangiogenesis; lymphatic microvessel density; lymphatic vessel; Merkel cell carcinoma; Merkel cell polyomavirus; tumor associated macrophages

Indexed keywords

CD163 ANTIGEN; CD68 ANTIGEN; KI 67 ANTIGEN; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR 3;

ADULT; AGED; ANATOMY; ARTICLE; CELL TYPE; CLINICAL ARTICLE; CLINICAL STUDY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOLOGY; LIVER METASTASIS; LYMPH NODE METASTASIS; LYMPHANGIOGENESIS; MACROPHAGE; MALE; MERKEL CELL POLYOMAVIRUS; MERKEL CELL TUMOR; MICROVASCULATURE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE;

AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CARCINOMA, MERKEL CELL; FEMALE; HUMANS; KI-67 ANTIGEN; LYMPHANGIOGENESIS; LYMPHATIC VESSELS; MACROPHAGES; MALE; MIDDLE AGED; RECEPTORS, CELL SURFACE; SKIN NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR D; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3; VESICULAR TRANSPORT PROTEINS;

EID: 84863985106     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2011.09.002     Document Type: Article

References (27)

1. B. Lemos, and P. Nghiem Merkel cell carcinoma: more deaths but still no pathway to blame J Invest Dermatol 127 2007 2100 2103 (Pubitemid 47258499)
2. E.A. Engels, M. Frisch, J.J. Goedert, R.J. Biggar, and R.W. Miller Merkel cell carcinoma and HIV infection Lancet 359 2002 497 498 (Pubitemid 34164301)
3. H. Feng, M. Shuda, Y. Chang, and P.S. Moore Clonal integration of a polyomavirus in human Merkel cell carcinoma Science 319 2008 1096 1100 (Pubitemid 351300792)
4. P. Helmbold, C. Lahtz, A. Enk, P. Herrmann-Trost, W. Marsch, and H. Kutzner Frequent occurrence of RASSF1A promoter hypermethylation and Merkel cell polyomavirus in Merkel cell carcinoma Mol Carcinog 48 2009 903 909
5. D. Schrama, W.K. Peitsch, M. Zapatka, H. Kneitz, R. Houben, and S. Eib Merkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma J Invest Dermatol 131 2011 1631 1638
6. M. Shuda, H. Feng, H.J. Kwun, S.T. Rosen, O. Gjoerup, and P.S. Moore T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus Proc Natl Acad Sci U S A 105 2008 16272 16277
7. S. Jackowski, M. Janusch, E. Fiedler, W.C. Marsch, E.J. Ulbrich, and G. Gaisbauer Radiogenic lymphangiogenesis in the skin Am J Pathol 171 2007 338 348 (Pubitemid 47339250)
8. L. Ronnov-Jessen, J.E. Celis, B. Van Deurs, and O.W. Petersen A fibroblast-associated antigen: characterization in fibroblasts and immunoreactivity in smooth muscle differentiated stromal cells J Histochem Cytochem 40 1992 475 486
9. J. Ralston, L. Chiriboga, and D. Nonaka MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma Mod Pathol 21 2008 1357 1362
10. A. Sierakowski, K. Al-Janabi, H. Dam, and M. Sood Metastatic Merkel cell carcinoma with positive expression of thyroid transcription factor-1-a case report Am J Dermatopathol 31 2009 384 386
11. V. Schacht, S.S. Dadras, L.A. Johnson, D.G. Jackson, Y.K. Hong, and M. Detmar Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors Am J Pathol 166 2005 913 921 (Pubitemid 40315647)
12. H. Liang, H. Wu, T.A. Giorgadze, D. Sariya, K.S. Bellucci, and R. Veerappan Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin Am J Surg Pathol 31 2007 304 310 (Pubitemid 46175033)
13. J.T. Rabban, and Y.Y. Chen D2-40 expression by breast myoepithelium: potential pitfalls in distinguishing intralymphatic carcinoma from in situ carcinoma Hum Pathol 39 2008 175 183
14. S.K. Lau, P.G. Chu, and L.M. Weiss CD163: a specific marker of macrophages in paraffin-embedded tissue samples Am J Clin Pathol 122 2004 794 801 (Pubitemid 39434761)
15. A. Lymboussaki, T.A. Partanen, B. Olofsson, J. Thomas-Crusells, C.D. Fletcher, and R.M. de Waal Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumors Am J Pathol 153 1998 395 403 (Pubitemid 28373651)
16. L. Jussila, R. Valtola, T.A. Partanen, P. Salven, P. Heikkila, and M.T. Matikainen Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3 Cancer Res 58 1998 1599 1604 (Pubitemid 28215077)
17. S.S. Dadras, T. Paul, J. Bertoncini, L.F. Brown, A. Muzikansky, and D.G. Jackson Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival Am J Pathol 162 2003 1951 1960 (Pubitemid 36613052)
18. L. Bingle, N.J. Brown, and C.E. Lewis The role of tumor-associated macrophages in tumor progression: implications for new anticancer therapies J Pathol 196 2002 254 265 (Pubitemid 34189413)
19. C.E. Lewis, and J.W. Pollard Distinct role of macrophages in different tumor microenvironments Cancer Res 66 2006 605 612 (Pubitemid 43165918)
20. J.D. Shields, M. Borsetti, H. Rigby, S.J. Harper, P.S. Mortimer, and J.R. Levick Lymphatic density and metastatic spread in human malignant melanoma Br J Cancer 90 2004 693 700 (Pubitemid 38297212)
21. T.O. Jensen, H. Schmidt, H.J. Moller, M. Hoyer, M.B. Maniecki, and P. Sjoegren Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma J Clin Oncol 27 2009 3330 3337
22. P. Allavena, A. Sica, G. Solinas, C. Porta, and A. Mantovani The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages Crit Rev Oncol Hematol 66 2008 1 9 (Pubitemid 351324128)
23. S. Hirakawa From tumor lymphangiogenesis to lymphvascular niche Cancer Sci 100 2009 983 989
24. S.S. Dadras, B. Lange-Asschenfeldt, P. Velasco, L. Nguyen, A. Vora, and A. Muzikansky Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes Mod Pathol 18 2005 1232 1242 (Pubitemid 43079923)
25. + macrophages in advanced ovarian cancer Cancer Res 68 2008 1100 1109 (Pubitemid 351272228)
26. S.F. Schoppmann, P. Birner, J. Stockl, R. Kalt, R. Ullrich, and C. Caucig Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis Am J Pathol 161 2002 947 956 (Pubitemid 34988382)
27. S.B. Coffelt, R. Hughes, and C.E. Lewis Tumor-associated macrophages: effectors of angiogenesis and tumor progression Biochim Biophys Acta 1796 2009 11 18