Effects of statin and deferoxamine administration on neurological outcomes in a rat model of intracerebral hemorrhage

Neurological Sciences

Volumn 33, Issue 2, 2012, Pages 289-296

  Chun, Hyoung Joon ^a   Kim, Dong Won ^a   Yi, Hyeong Joong ^a   Kim, Young Soo ^a   Kim, Eun Hyun ^a   Hwang, Se Jin ^a   Jwa, Cheol Su ^b   Lee, Yoon Kyoung ^c   Ryou, Hyunchul ^d  

^a Hanyang University   (South Korea)

^b National Medical Center   (South Korea)

^c Department of Nursing   (South Korea)

^d Department of Occupational and Environmental Medicine   (South Korea)

Author keywords

Deferoxamine; Inflammation; Intracerebral hemorrhage; Iron; Neuroprotection; Statin

Indexed keywords

DEFEROXAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SIMVASTATIN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN ATROPHY; BRAIN EDEMA; BRAIN HEMATOMA; BRAIN HEMORRHAGE; CELL ACTIVATION; CELL INFILTRATION; CONTROLLED STUDY; DRUG ACTIVITY; ENCEPHALITIS; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MONOTHERAPY; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; RAT; WATER CONTENT;

ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD11B; ATROPHY; BRAIN EDEMA; CEREBRAL HEMORRHAGE; DEFEROXAMINE; DISEASE MODELS, ANIMAL; EXTREMITIES; GLIAL FIBRILLARY ACIDIC PROTEIN; HEMATOMA; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; NERVOUS SYSTEM DISEASES; PSYCHOMOTOR PERFORMANCE; RATS; RATS, SPRAGUE-DAWLEY; SIDEROPHORES; SPATIAL BEHAVIOR;

EID: 84863982448     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-011-0733-y     Document Type: Article

References (23)

1. Sacco S, Marini C, Toni S, Olivieri L, Carolei A (2009) Incidence and 10-year survival of intracerebral hemorrhage in populationbased registry. Stroke 40:394-399
2. Xi G, Keep RF, Hoff JT (2006) Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol 5:53-63 (Pubitemid 41790696)
3. Xue M, Del Bigio MR (2000) Intracerebral injection of autologous whole blood in rats: time course of inflammation and cell death. Neurosci Lett 283:230-232 (Pubitemid 30168975)
4. Jung JH, Chu K, Jeong SW, Han SY, Lee ST, Kim JY, Kim MH, Roh JK (2004) HMG-CoA reductase inhibitor, atorvastatin, promotes sensorimotor recovery, suppressing acute inflammatory reaction after experimental intracerebral hemorrhage. Stroke 35:1744-1749 (Pubitemid 38823658)
5. Okauchi M, Hua Y, Keep RF, Morgenstern LB, Schallert T, Xi G (2010) Deferoxamine treatment for intracerebral hemorrhage in aged rats. Therapeutic time window and optimal duration. Stroke 41:375-382
6. Selim M (2009) Deferoxamine mesylate. A new hope for intracerebral hemorrhage: from bench to clinical trials. Stroke 40:S90-S91
7. Chen J, Zhang ZG, Li Y, Wang Y, Wang L, Jiang H, Zhang C, Lu M, Katakowski M, Feldkamp CS, Chopp M (2003) Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol 53:743-751 (Pubitemid 36622511)
8. Gu Y, Hua Y, Keep RF, Morgenstern LB, Xi G (2009) Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets. Stroke 40:2241-2243
9. Xing Y, Hua Y, Keep RF, Xi G (2009) Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia. Brain Res 1291:113-121
10. Kawashima S, Yamashita T, Miwa Y, Ozaki M, Namiki M, Hirase T, Inoue N, Hirata K, Yokoyama M (2003) HMG-CoA reductase inhibitor has protective effects against stroke events in stroke-prone spontaneously hypertensive rats. Stroke 34:157-163 (Pubitemid 36070817)
11. Song EC, Chu K, Jeong SW, Jung KH, Kim SH, Kim M, Yoon BW (2003) Hyperglycemia exacerbates brain edema and perihematomal cell death after intracerebral hemorrhage. Stroke 34:2215-2220 (Pubitemid 37099839)
12. Hua Y, Schallert T, Keep RF, Wu J, Hoff JT, Xi G (2002) Behavioral tests after intracerebral hemorrhage in the rat. Stroke 33:2478-2784
13. Zazulia AR, Diringer MN, Derdeyn CP, Powers WJ (1999) Progression of mass effect after intracerebral hemorrhage. Stroke 30:1167-1173 (Pubitemid 29259168)
14. Yang GY, Betz AL, Chenevert TL, Brunberg JA, Hoff JT (1994) Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats. J Neurosurg 81:93-102 (Pubitemid 24195513)
15. Xi G, Keep RF, Hoff JT (1998) Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J Neurosurg 89:991-996 (Pubitemid 28544054)
16. Xi G, Wagner KR, Keep RF, Hua Y, de Courten-Myers GM, Broderick JP, Brott TG, Hoff JT (1998) The role of blood clot formation on early edema development following experimental intracerebral hemorrhage. Stroke 29:2580-2586 (Pubitemid 28544010)
17. Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G (2003) Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 34:2964-2969 (Pubitemid 37517778)
18. Nogawa S, Forster C, Zhang F, Nagayama M, Ross ME, Iadecola C (1998) Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia. Proc Natl Acad Sci USA 95:10966-10971
19. Tanji K, Imaizumi T, Matsumiya T, Itaya H, Fujimoto K, Cui X, Toki T, Ito E, Yoshida H, Wakabayashi K, Satoh K (2001) Desferrioxamine, an iron chelator, upregulates cyclooxygenase-2 expression and prostaglandin production in a human macrophage cell line. Biochim Biophys Acta 1530:227-235 (Pubitemid 32182432)
20. Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G (2004) Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. J Neurosurg 100:672-678 (Pubitemid 38372849)
21. Okauchi M, Hua Y, Keep RF, Morgenstern LB, Xi G (2009) Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats. Stroke 40:1858-1863
22. Tapia-Perez H, Sanchez-Aguilar M, Torres-Corzo JG, Rodriguez-Leyva I, Gonzalez-Aguirre D, Gordillo-Moscoso A, Chalita-Williams C (2009) Use of statins for the treatment of spontaneous intracerebral hemorrhage: results of a pilot study. Cen Eur Neurosurg 70:15-20
23. Cappellini MD, Musallam KM, Taher AT (2009) Overview of iron chelation therapy with desferrioxamine and deferiprone. Hemoglobin 33(Suppl 1):S58-S69