Melanocortin 1 receptor function: Shifting gears from determining skin and nevus phenotype to fetal growth

Journal of Investigative Dermatology

Volumn 132, Issue 8, 2012, Pages 1953-1955

  Gruis, Nelleke A ^a   Van Doorn, Remco ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CORTICOTROPIN; EUMELANIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERMEDIN; MELANOCORTIN 1 RECEPTOR; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; PHEOMELANIN; PROOPIOMELANOCORTIN; PROTEIN BCL 2; SCATTER FACTOR RECEPTOR; VITAMIN D;

BIRTH WEIGHT; BODY MASS; CHROMOSOME 16Q; DISEASE COURSE; DNA DAMAGE; EMBRYO DEVELOPMENT; FAMILY HISTORY; FETUS GROWTH; FIBROBLAST; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GESTATIONAL AGE; HUMAN; IN VITRO STUDY; KERATINOCYTE; MATERNAL AGE; MELANOCYTE; MELANOCYTIC NEVUS; PARITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REVIEW; RISK FACTOR; SKIN; SMOKING; SOCIAL STATUS; ULTRAVIOLET RADIATION;

EID: 84863947684     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.216     Document Type: Note

References (13)

1. Bodnar LM, Catov JM, Zmuda JM et al. (2010) Maternal serum 25-hydroxyvitamin D concentrations are associated with smallfor-gestational age births in white women. J Nutr 140:999-1006
2. Brzoska T, Luger TA, Maaser C et al. (2008) Alphamelanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev 29:581-602
3. Cardones AR, Grichnik JM (2009) a-Melanocytestimulating hormone-induces eruptive. Nevi Arch Dermatol 145:441-4
4. Cheli Y, Ohanna M, Ballotti R et al. (2010) Fifteenyear quest for microphthalmia-associated transcription factor target genes. Pigment Cell Melanoma Res 23:27-40
5. Dessinioti C, Antoniou C, Katsambas A et al. (2011) Melanocortin 1 receptor variants: functional role and pigmentary associations. Photochem Photobiol 87:978-87
6. Freathy RM, Mook-Kanamori DO, Sovio U et al. (2010) Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet 42:430-5
7. Grässel S, Opolka A, Anders S et al. (2009) The melanocortin system in articular chondrocytes: melanocortin receptors, pro-opiomelanocortin, precursor proteases, and a regulatory effect of alpha-melanocyte-stimulating hormone on proinflammatory cytokines and extracellular matrix components. Arthritis Rheum 60:3017-27
8. Kadekaro AL, Leachman S, Kavanagh RJ et al. (2010) Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation. FASEB J 24:3850-60
9. Kinsler VA, Abu-Amero S, Budd P et al. (2012) Severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development. J Invest Dermatol 132:2026-32
10. Mller CL, Raun K, Jacobsen ML et al. (2011) Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved. Mol Cell Endocrinol 341:9-17
11. Robbins LS, Nadeau JH, Johnson KR et al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72:827-34
12. Stanisz H, Seifert M, Tilgen W et al. (2011) Reciprocal responses of fibroblasts and melanocytes to a-MSH depending on MC1R polymorphisms. Dermatoendocrinol 3:259-65
13. Sturm RA (2002) Skin colour and skin cancer-MC1R, the genetic link. Melanoma Res 12:405-16