Serum levels of the adipokine zinc-α2-glycoprotein are increased in preeclampsia

Journal of Endocrinological Investigation

Volumn 35, Issue 6, 2012, Pages 562-565

  Stepan, H ^a   Philipp, A ^a   Roth, I ^a   Kralisch, S ^a,b   Jank, A ^a   Schaarschmidt, W ^a   Lossner U ^a,b   Kratzsch, J ^a   Bluher M ^a   Stumvoll, M ^a   Fasshauer, M ^a,b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Adipokine; Insulin resistance; Obesity; Preeclampsia; ZAG

Indexed keywords

ADIPOCYTOKINE; CREATININE; LEPTIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ZINC ALPHA2 GLYCOPROTEIN;

ADULT; ARTICLE; BIRTH WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; FEMALE; GLUCOSE METABOLISM; HUMAN; KIDNEY FUNCTION; LIPID METABOLISM; MATERNAL SERUM; PREECLAMPSIA; PROTEIN BLOOD LEVEL; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

ADIPOKINES; ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFANT, NEWBORN; PRE-ECLAMPSIA; PREGNANCY; RISK FACTORS; SEMINAL PLASMA PROTEINS; YOUNG ADULT;

EID: 84863946806     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/7877     Document Type: Article

References (36)

1. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Preeclampsia. Lancet 2010, 376: 631-44.
2. Stepan H, Geide A, Faber R. Soluble fms-like tyrosine kinase 1. N Engl J Med 2004, 351: 2241-2.
3. Stepan H. Angiogenic factors and pre-eclampsia: an early marker is needed. Clin Sci (Lond) 2009, 116: 231-2.
4. Stepan H, Faber R. Elevated sFlt1 level and preeclampsia with parvovirus-induced hydrops. N Engl J Med 2006, 354: 1857-8.
5. Stepan H, Unversucht A, Wessel N, Faber R. Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion. Hypertension 2007, 49: 818-24. (Pubitemid 351664216)
6. Poston L. Leptin and preeclampsia. Semin Reprod Med 2002, 20: 131-8. (Pubitemid 34764277)
7. Tommaselli GA, Pighetti M, Nasti A, et al. Serum leptin levels and uterine Doppler flow velocimetry at 20 weeks' gestation as markers for the development of pre-eclampsia. Gynecol Endocrinol 2004, 19: 160-5. (Pubitemid 39486903)
8. Conrad KP, Miles TM, Benyo DF. Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol 1998, 40: 102-11.
9. LaMarca BB, Bennett WA, Alexander BT, Cockrell K, Granger JP. Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of tumor necrosis factor-alpha. Hypertension 2005, 46: 1022-5.
10. Freeman DJ, McManus F, Brown EA, et al. Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension 2004, 44: 708-14. (Pubitemid 39435242)
11. Burgi W, Schmid K. Preparation and properties of Zn-alpha 2-glycoprotein of normal human plasma. J Biol Chem 1961, 236: 1066-74.
12. Hirai K, Hussey HJ, Barber MD, Price SA, Tisdale MJ. Biological evaluation of a lipid-mobilizing factor isolated from the urine of cancer patients. Cancer Res 1998, 58: 2359-65. (Pubitemid 28252695)
13. Russell ST, Zimmerman TP, Domin BA, Tisdale MJ. Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha2-glycoprotein. Biochim Biophys Acta 2004, 1636: 59-68. (Pubitemid 38231005)
14. Bao Y, Bing C, Hunter L, Jenkins JR, Wabitsch M, Trayhurn P. Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proc Natl Acad Sci U S A 2004, 101: 2500-5. (Pubitemid 38269340)
15. Bao Y, Bing C, Hunter L, Jenkins JR, Wabitsch M, Trayhurn P. Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes. FEBS Lett 2005, 579: 41-7. (Pubitemid 40023371)
16. Gohda T, Makita Y, Shike T, et al. Identification of epistatic interaction involved in obesity using the KK/Ta mouse as a Type 2 diabetes model: is Zn-alpha2 glycoprotein-1 a candidate gene for obesity? Diabetes 2003, 52: 2175-81. (Pubitemid 36919814)
17. Mracek T, Ding Q, Tzanavari T, et al. The adipokine zinc-alpha2- glycoprotein is downregulated with fat mass expansion in obesity. Clin Endocrinol (Oxf) 2010, 72: 334-41.
18. Ceperuelo-Mallafre V, Naf S, Escote X, et al. Circulating and adipose tissue gene expression of zinc-alpha2-glycoprotein in obesity: its relationship with adipokine and lipolytic gene markers in subcutaneous and visceral fat. J Clin Endocrinol Metab 2009, 94: 5062-9.
19. Gong FY, Zhang SJ, Deng JY, et al. Zinc-alpha2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue. Int J Obes (Lond) 2009, 33: 1023-30.
20. Philipp A, Kralisch S, Bachmann A, et al. Serum levels of the adipokine zinc-alpha2-glycoprotein are increased in chronic hemodialysis. Metabolism 2011, 60: 669-72.
21. Selva DM, Lecube A, Hernandez C, Baena JA, Fort JM, Simo R. Lower zinc-alpha2-glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance. J Clin Endocrinol Metab 2009, 94: 4499-507.
22. Yeung DC, Lam KS, Wang Y, Tso AW, Xu A. Serum zinc-alpha2-glycoprotein correlates with adiposity, triglycerides, and the key components of the metabolic syndrome in Chinese subjects. J Clin Endocrinol Metab 2009, 94: 2531-6.
23. Stejskal D, Karpísek M, Reutová H, Stejskal P, Kotolová H, Kollár P. Determination of serum zinc-alpha-2- glycoprotein in patients with metabolic syndrome by a new ELISA. Clin Biochem 2008, 41: 313-6.
24. National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000, 183: S1-22.
25. Fasshauer M, Blüher M, Stumvoll M, Tönessen P, Faber R, Stepan H. Differential regulation of visfatin and adiponectin in pregnancies with normal and abnormal placental function. Clin Endocrinol (Oxf) 2007, 66: 434-9. (Pubitemid 46239304)
26. Fasshauer M, Waldeyer T, Seeger J, et al. Serum levels of the adipokine visfatin are increased in preeclampsia. Clin Endocrinol (Oxf) 2008, 69: 69-73. (Pubitemid 351847262)
27. Fasshauer M, Waldeyer T, Seeger J, et al. Circulating high molecular weight adiponectin is upregulated in preeclampsia and is related to insulin sensitivity and renal function. Eur J Endocrinol 2008, 158: 197-201. (Pubitemid 351298536)
28. Fasshauer M, Seeger J, Waldeyer T, et al. Serum levels of the adipokine adipocyte fatty acid-binding protein are increased in preeclampsia. Am J Hypertens 2008, 21: 582-6. (Pubitemid 351589677)
29. Stepan H, Philipp A, Reiche M, et al. Serum levels of the adipokine lipocalin-2 are increased in preeclampsia. J Endocrinol Invest 2010, 33: 629-32.
30. Rolli V, Radosavljevic M, Astier V, et al. Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice. FEBS Lett 2007, 581: 394-400. (Pubitemid 46157227)
31. Endresen MJ, Lorentzen B, Henriksen T. Increased lipolytic activity and high ratio of free fatty acids to albumin in sera from women with preeclampsia leads to triglyceride accumulation in cultured endothelial cells. Am J Obstet Gynecol 1992, 167: 440-7.
32. Zoccali C, Mallamaci F, Tripepi G, et al. Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease. J Am Soc Nephrol 2002, 13: 134-41. (Pubitemid 34042020)
33. Merabet E, Dagogo-Jack S, Coyne DW, et al. Increased plasma leptin concentration in end-stage renal disease. J Clin Endocrinol Metab 1997, 82: 847-50. (Pubitemid 27106599)
34. Ziegelmeier M, Bachmann A, Seeger J, et al. Serum levels of the adipokine RBP-4 in relation to renal function. Diabetes Care 2007, 30: 2588-92. (Pubitemid 47547801)
35. Sommer G, Ziegelmeier M, Bachmann A, et al. Serum levels of adipocyte fatty acid binding protein are increased in chronic haemodialysis. Clin Endocrinol (Oxf) 2008, 69: 901-5.
36. Stein S, Bachmann A, Lossner U, et al. Serum levels of the adipokine FGF21 depend on renal function. Diabetes Care 2009, 32: 126-8.