Simultaneous LC-MS/MS quantitation of acetaminophen and its glucuronide and sulfate metabolites in human dried blood spot samples collected by subjects in a pilot clinical study

Bioanalysis

Volumn 4, Issue 12, 2012, Pages 1429-1443

  Li, Wenkui ^a   Doherty, John P ^a   Kulmatycki, Kenneth ^a   Smith, Harold T ^a   Tse, Francis Ls ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; PARACETAMOL; PARACETAMOL GLUCURONIDE; PARACETAMOL SULFATE;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRIED BLOOD SPOT TESTING; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STRUCTURE; FRAGMENTATION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHASE SEPARATION; PILOT STUDY; PROCESS OPTIMIZATION; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; CHROMATOGRAPHY, REVERSE-PHASE; DRIED BLOOD SPOT TESTING; HUMANS; LIMIT OF DETECTION; METHANOL; PILOT PROJECTS; REFERENCE STANDARDS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

EID: 84863908331     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.119     Document Type: Article

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