Directing neuronal differentiation of primary neural progenitor cells by gene knockdown approach

DNA and Cell Biology

Volumn 31, Issue 7, 2012, Pages 1148-1160

  Low, Wei Ching ^a   Yau, Winifred Wing Yiu ^a   Stanton, Lawrence W ^b   Marcy, Guillaume ^c   Goh, Eyleen ^c   Chew, Sing Yian ^a  

^a Nanyang Technological University   (Singapore)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PROTEIN TUJ1; RE1 SILENCING TRANSCRIPTION FACTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; GENE SILENCING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UPREGULATION;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CULTURE MEDIA; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; KINETICS; MICE; MICE, INBRED C57BL; NEURAL STEM CELLS; NEURONS; REPRESSOR PROTEINS; RNA INTERFERENCE;

EID: 84863900623     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.2011.1557     Document Type: Article

References (30)

1. Ballas, N., Grunseich, C., Lu, D.D., Speh, J.C., and Mandel, G. (2005). REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121, 645-657.
2. Bartlett, P.F., Brooker, G.J., Faux, C.H., Dutton, R., Murphy, M., Turnley, A., and Kilpatrick, T.J. (1998). Regulation of neural stem cell differentiation in the forebrain. Immunol Cell Biol 76, 414-418.
3. Bull, N.D., and Bartlett, P.F. (2005). The adult mouse hippocampal progenitor is neurogenic but not a stem cell. J Neurosci 25, 10815-10821.
4. Cao, H., Jiang, X., Chai, C., and Chew, S.Y. (2010). RNA interference by nanofiber-based siRNA delivery system. J Controlled Release 144, 203-212.
5. Carlberg, B., Axell, M.Z., Nannmark, U., Liu, J., and Kuhn, H.G. (2009). Electrospun polyurethane scaffolds for proliferation and neuronal differentiation of human embryonic stem cells. Biomedical Materials 4, 045004.
6. Chong, J.A., Tapia-Ramirez, J., Kim, S., Toledo-Aral, J.J., Zheng, Y., Boutros, M.C., Altshuller, Y.M., Frohman, M.A., Kraner, S.D., and Mandel G. (1995). REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80, 949-957.
7. Christopherson, G.T., Song, H., and Mao, H.-Q. (2009). The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation. Biomaterials 30, 556-564.
8. Conti, L., Pollard, S.M., Gorba, T., Reitano, E., Toselli, M., Biella, G., Sun, Y., Sanzone, S., Ying, Q.-L., Cattaneo, E., and Smith A. (2005). Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. PLoS Biol 3, e283.
9. Davidson, B.L., and McCray, P.B. (2011). Current prospects for RNA interference-based therapies. Nat Rev Genet 12, 329-340.
10. Dharmapuri, S., Peruzzi, D., Marra, E., Palombo, F., Bett, A.J., Bartz, S.R., Yong, M., Ciliberto, G., La Monica, N., Buser, C.A., Toniatti, C., and Aurisicchio L. (2011). Intratumor RNA interference of cell cycle genes slows down tumor progression. Gene Ther 18, 727-733.
11. Gao, Z., Ure, K., Ding, P., Nashaat, M., Yuan, L., Ma, J., Hammer, R.E., and Hsieh J. (2011). The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells. J Neurosci 31, 9772-9786.
12. He, L., Liao, S., Quan, D., Ma, K., Chan, C., Ramakrishna, S., and Lu J. (2010). Synergistic effects of electrospun PLLA fiber dimension and pattern on neonatal mouse cerebellum C17.2 stem cells. Acta Biomaterialia 6, 2960-2969.
13. Hong, C.S., Goins, W.F., Goss, J.R., Burton, E.A., and Glorioso, J.C. (2006). Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's diseaserelated amyloid-[beta] peptide in vivo. Gene Ther 13, 1068-1079.
14. Kim, Y.H., Chung, J.-I., Woo, H.G., Jung, Y.-S., Lee, S.H., Moon, C.-H., Suh-Kim, H., and Baik, E.J. (2010). Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway. Stem Cells 28, 1816-1828.
15. Kumar Gupta, S., Gressens, P., and Mani, S. (2009). NRSF downregulation induces neuronal differentiation in mouse embryonic stem cells. Differentiation 77, 19-28.
16. Lepagnol-Bestel, A.M., Maussion, G., Ramoz, N., Moalic, J.M., Gorwood, P., and Simonneau M. (2007). Nrsf silencing induces molecular and subcellular changes linked to neuronal plasticity. Neuroreport 18, 441.
17. Levy, O., Ruvinov, E., Reem, T., Granot, Y., and Cohen S. (2010). Highly efficient osteogenic differentiation of human mesenchymal stem cells by eradication of STAT3 signaling. Int J Biochem Cell Biol 42, 1823-1830.
18. Ma, Y., Jin, J., Dong, C., Cheng, E.-C., Lin, H., Huang, Y., and Qiu, C. (2010). High-efficiency siRNA-based gene knockdown in human embryonic stem cells. RNA 16, 2564-2569.
19. Paquette, A.J., Perez, S.E., and Anderson, D.J. (2000). Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo. Proc Natl Acad Sci 97, 12318-12323.
20. Peltier, J., Ormerod, B.K., and Schaffer, D.V. (2010). Isolation of adult hippocampal neural progenitors protocols for adult stem cells. In I.M. Conboy, M.H. Barcellos-Hoff, D.V. Schaffer, and S. Li, eds. (Humana Press, NY, USA), pp. 57-63.
21. Raff, M.C., Miller, R.H., and Noble, M. (1983). A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium. Nature 303, 390-396.
22. Rujitanaroj, P.-O., Wang, Y.-C., Wang, J., and Chew, S.Y. (2011). Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications. Biomaterials 32, 5915-5923.
23. Schoenherr, C.J., and Anderson, D.J. (1995). The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes. Science 267, 1360-1363.
24. Singer, O., Marr, R.A., Rockenstein, E., Crews, L., Coufal, N.G., Gage, F.H., Verma, I.M., and Masliah E. (2005). Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci 8, 1343-1349.
25. Sluijter, J.P.G., Van Mil, A., Van Vliet, P., Metz, C.H.G., Liu, J., Doevendans, P.A., and Goumans, M.-J. (2010). MicroRNA-1 and - 499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells. Arterioscler Thromb and Vasc Biol 30, 859-868.
26. Sun, Y.-M., Greenway, D.J., Johnson, R., Street, M., Belyaev, N.D., Deuchars, J., Bee, T.,Wilde, S., and Buckley, N.J. (2005). Distinct profiles of REST interactions with its target genes at different stages of neuronal development. Mol Biol Cell 16, 5630-5638.
27. Whitney, N.P., Peng, H., Erdmann, N.B., Tian, C., Monaghan, D.T., and Zheng, J.C. (2008). Calcium-permeable AMPA receptors containing Q/R-unedited GluR2 direct human neural progenitor cell differentiation to neurons. Faseb J 22, 2888-2900.
28. Wurdak, H, et al. (2010). A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci 107, 16542-16547.
29. Xie, J., Willerth, S.M., Li, X., Macewan, M.R., Rader, A., Sakiyama-Elbert, S.E., and Xia Y. (2009). The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages. Biomaterials 30, 354-362.
30. Yang, Y., Li, Y., Lv, Y., Zhang, S., Chen, L., Bai, C., Nan, X., Yue, W., and Pei X. (2008). NRSF silencing induces neuronal differentiation of human mesenchymal stem cells. Exp Cell Res 314, 2257-2265.