AGTR1 gene variation: Association with depression and frontotemporal morphology

Psychiatry Research - Neuroimaging

Volumn 202, Issue 2, 2012, Pages 104-109

  Taylor, Warren D ^a,c   Benjamin, Sophiya ^a   McQuoid, Douglas R ^a   Payne, Martha E ^a,c   Krishnan, Ranga R ^a,d   MacFall, James R ^a,c   Ashley Koch, Allison ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY   (United States)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Amygdala; Genetic polymorphisms; Geriatrics; Hippocampus; MRI; Prefrontal cortex; Renin angiotensin system

Indexed keywords

ANGIOTENSIN 1 RECEPTOR;

ADULT; AGED; AGTR1 GENE; ARTICLE; BRAIN SIZE; DEPRESSION; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HIPPOCAMPUS; HUMAN; LEFT HEMISPHERE; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PREFRONTAL CORTEX; PRIORITY JOURNAL; RIGHT HEMISPHERE; SINGLE NUCLEOTIDE POLYMORPHISM; WHITE MATTER;

AGED; AGED, 80 AND OVER; DEPRESSIVE DISORDER, MAJOR; FEMALE; FRONTAL LOBE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, ANGIOTENSIN, TYPE 1; TEMPORAL LOBE;

EID: 84863873058     PISSN: 09254927     EISSN: 18727506     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2012.03.007     Document Type: Article

References (67)

1. Aguilera G., Young W.S., Kiss A., Bathia A. Direct regulation of hypothalamic corticotropin-releasing-hormone neurons by angiotensin II. Neuroendocrinology 1995, 61:437-444.
2. Alexopoulos G.S., Meyers B.S., Young R.C., Campbell S., Silbersweig D., Charlson M. 'Vascular depression' hypothesis. Archives of General Psychiatry 1997, 54:915-922.
3. Arinami T., Li L., Mitsushio H., Itokawa M., Hamaguchi H., Toru M. An insertion/deletion polymorphism in the angiotensin converting enzyme gene is associated with both brain substance P contents and affective disorders. Biological Psychiatry 1996, 40:1122-1127.
4. Armando I., Volpi S., Aguilera G., Saavedra J.M. Angiotensin II AT1 receptor blockade prevents the hypothalamic corticotropin-releasing factor response to isolation stress. Brain Research 2007, 1142:92-99.
5. Baghai T.C., Binder E.B., Schule C., Salyakina D., Eser D., Lucae S., Zwanger P., Harberger C., Zill P., Ising M., Deiml T., Uhr M., Ilig T., Wichmann H.E., Modell S., Nothdurfter C., Holsboer F., Muller-Myhsok B., Moller H.J., Rupprecht R., Bondy B. Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Molecular Psychiatry 2006, 11:1003-1015.
6. Bahrami H., Fang B., Bluemke D.A., Heckbert S., Kaufman J., Young J.H., Guo X., Fernandes V., Herrington D., Shea S., Rotter J.I., Post W., Lima J.A. Association of polymorphisms in genes related to renin-angiotensin-aldosterone system with left ventricular structure and function and incident heart failure in four ethnic groups; the multi-ethnic study of atherosclerosis. Circulation 2008, 118:S1102.
7. Bondy B., Baghai T.C., Zill P., Schule C., Eser D., Deiml T., Zwanzger P., Ella R., Rupprecht R. Genetic variants in the angiotensin I-converting-enzyme (ACE) and angiotensin II receptor (AT1) gene and clinical outcome in depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2005, 29:1094-1099.
8. Bosker F.J., Hartman C.A., Nolte I.M., Prins B.P., Terpstra P., Posthuma D., van Veen T., Willemsen G., Derijk R.H., de Geus E.J., Hoogendijk W.J., Sullivan P.F., Penninx B.W., Boomsma D.I., Snieder H., Nolen W.A. Poor replication of candidate genes for major depressive disorder using genome-wide association data. Molecular Psychiatry 2011, 16:516-532.
9. Brown N.J., Blais C., Gandhi S.K., Adam A. ACE insertion/deletion genotype affects bradykinin metabolism. Journal of Cardiovascular Pharmacology 1998, 32:373-377.
10. Carlson C.S., Eberle M.A., Rieder M.J., Yi Q., Kruglyak L., Nickerson D.A. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. American Journal of Human Genetics 2004, 74:106-120.
11. Castren E. Is mood chemistry?. Nature Reviews Neuroscience 2005, 6:241-246.
12. Chang C.C., Yu S.C., McQuoid D.R., Messer D.F., Taylor W.D., Singh K., Boyd B.D., Krishnan K.R., MacFall J.R., Steffens D.C., Payne M.E. Reduction of dorsolateral prefrontal cortex gray matter in late-life depression. Psychiatry Research Neuroimaging 2011, 193:1-6.
13. De Bundel D., Smolders I., Vanderheyden P., Michotte Y. Ang II and Ang IV: unraveling the mechanism of action on synaptic plasticity, memory, and epilepsy. CNS Neuroscience and Therapeutics 2008, 14:315-339.
14. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 1975, 12:189-198.
15. Gard P.R. The role of angiotensin II in cognition and behaviour. European Journal of Pharmacology 2002, 438:1-14.
16. Gard P.R., Mandy A., Sutcliffe M.A. Evidence of a possible role of altered angiotensin function in the treatment, but not etiology, of depression. Biological Psychiatry 1999, 45:1030-1034.
17. Gelband C.H., Sumners C., Lu D., Raizada M.K. Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling. Regulatory Peptides 1997, 72:139-145.
18. Gerritsen L., Comijs H.C., van der Graaf Y., Knoops A.J., Penninx B.W., Geerlings M.I. Depression, hypothalamic pituitary adrenal axis, and hippocampal and entorhinal cortex volumes-the SMART Medea study. Biological Psychiatry 2011, 70:373-380.
19. Giardina W.J., Ebert D.M. Positive effects of captopril in the behavioral despair swim test. Biological Psychiatry 1989, 25:697-702.
20. Grool A.M., van der Graaf Y., Mali W.P., Geerlings M.I. Location of cerebrovascular and degenerative changes, depressive symptoms and cognitive functioning in later life: the SMART-Medea study. Journal of Neurology, Neurosurgery, and Psychiatry 2011, 82:1093-1100.
21. 894T gene polymorphisms with silent subcortical white matter lesions in essential hypertension. Stroke 2005, 36:1869-1873.
22. Herman J.P., Ostrander M.M., Mueller N.K., Figueiredo H. Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2005, 29:1201-1213.
23. Hindorff L.A., Heckbert S.R., Tracy R., Tang Z., Psaty B.M., Edwards K.L., Siscovick D.S., Kronmal R.A., Nazar-Stewart V. Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events. American Journal of Hypertension 2002, 15:1050-1056.
24. Hou Z., Yuan Y., Zhang Z., Hou G., You J., Bai F. The D-allele of ACE insertion/deletion polymorphism is associated with regional white matter volume changes and cognitive impairment in remitted geriatric depression. Neuroscience Letters 2010, 479:262-266.
25. Johren O., Saavedra J.M. Expression of AT1A and AT1B angiotensin II receptor messenger RNA in forebrain of 2-wk-old rats. American Journal of Physiology 1996, 271:E104-E112.
26. Kempton M.J., Salvador Z., Munafo M.R., Geddes J.R., Simmons A., Frangou S., Williams S.C. Structural neuroimaging studies in major depressive disorder: meta-analysis and comparison with bipolar disorder. Archives of General Psychiatry 2011, 68:675-690.
27. Kondo D.G., Speer M.C., Krishnan K.R., McQuoid D.R., Slifer S.H., Pieper C.F., Billups A.V., Steffens D.C. Association of AGTR1 with 18-month treatment outcome in late-life depression. The American Journal of Geriatric Psychiatry 2007, 15:564-572.
28. Koolschijn P.C., van Haren N.E., Lensvelt-Mulders G.J., Hulshoff Pol H.E., Kahn R.S. Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studies. Human Brain Mapping 2009, 30:3719-3735.
29. Krishnan V., Nestler E.J. Linking molecules to mood: new insight into the biology of depression. The American Journal of Psychiatry 2010, 167:1305-1320.
30. Krishnan K.R.R., Tayor W.D., McQuoid D.R., MacFall J.R., Payne M.E., Provenzale J.M., Steffens D.C. Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression. Biological Psychiatry 2004, 55:390-397.
31. Lanz T.V., Ding Z., Ho P.P., Luo J., Agrawal A.N., Srinagesh H., Axtell R., Zhang H., Platten M., Wyss-Coray T., Steinman L. Angiotensin II sustains brain inflammation in mice via TGF-beta. Journal of Clinical Investigation 2010, 120:2782-2794.
32. Lenkei Z., Palkovits M., Corvol P., Llorens-Cortes C. Distribution of angiotensin II type-2 receptor (AT2) mRNA expression in the adult rat brain. The Journal of Comparative Neurology 1996, 373:322-339.
33. Li J., Ji L. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 2005, 95:221-227.
34. Lopez-Leon S., Janssens A.C., Hofman A., Claes S., Breteler M.M., Tiemeier H., van Duijn C.M. No association between the angiotensin-converting enzyme gene and major depression: a case-control study and meta-analysis. Psychiatric Genetics 2006, 16:225-226.
35. Lopez-Leon S., Janssens A.C., Tiemeier H., Hofman A., Aulchenko Y.S., Snijders P.J., Claes S., Oostra B.A., van Duijn C.M. Angiotensinogen M235T polymorphism and symptoms of depression in a population-based study and a family-based study. Psychiatric Genetics 2008, 18:162-166.
36. Macova M., Pavel J., Saavedra J.M. A peripherally administered, centrally acting angiotensin II AT2 antagonist selectively increases brain AT1 receptors and decreases brain tyrosine hydroxylase transcription, pituitary vasopressin and ACTH. Brain Research 2009, 1250:130-140.
37. Martin P., Massol J., Puech A.J. Captopril as an antidepressant? Effects on the learned helplessness paradigm in rats. Biological Psychiatry 1990, 27:968-974.
38. Miller A.H., Maletic V., Raison C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biological Psychiatry 2009, 65:732-741.
39. Montgomery S.A., Åsberg M. A new depression scale designed to be sensitive to change. The British Journal of Psychiatry 1979, 134:382-389.
40. Nayak V., Patil P.A. Antidepressant activity of fosinopril, ramipril and losartan, but not of lisinopril in depressive paradigms of albino rats and mice. Indian Journal of Experimental Biology 2008, 46:180-184.
41. Nie S.J., Wen-ru T., Bi-feng C., Jin L., Wen Z., Sheng-jun L., Wei-wei L., Hai-jing Y., Chun-jie X. Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects. Clinical Biochemistry 2010, 43:253-258.
42. Payne M.E., Fetzer D.L., MacFall J.R., Provenzale J.M., Byrum C.E., Krishnan K.R.R. Development of a semi-automated method for quantification of MRI gray and white matter lesions in geriatric subjects. Psychiatry Research Neuroimaging 2002, 115:63-77.
43. Pruessner J.C., Dedovic K., Pruessner M., Lord C., Buss C., Collins L., Dagher A., Lupien S.J. Stress regulation in the central nervous system: evidence from structural and functional neuroimaging studies in human populations - 2008 Curt Richter Award Winner. Psychoneuroendocrinology 2010, 35:179-191.
44. Qiu A., Taylor W.D., Zhao Z., MacFall J.R., Miller M.I., Key C.R., Payne M.E., Steffens D.C., Krishnan K.R. APOE related hippocampal shape alteration in geriatric depression. NeuroImage 2009, 44:620-626.
45. Rasetti R., Weinberger D.R. Intermediate phenotypes in psychiatric disorders. Current Opinion in Genetics and Development 2011, 21:340-348.
46. Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. Journal of Clinical Investigation 1990, 86:1343-1346.
47. Robins L.N., Helzer J.E., Croughan J., Ratcliff K.S. National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. Archives of General Psychiatry 1981, 38:381-389.
48. Ruano G., Thompson P.D., Windemuth A., Smith A., Kocherla M., Holford T.R., Seip R., Wu A.H. Physiogenomic analysis links serum creatine kinase activities during statin therapy to vascular smooth muscle homeostasis. Pharmacogenomics 2005, 6:865-872.
49. Saab Y.B., Gard P.R., Yeoman M.S., Mfarrej B., El-Moalem H., Ingram M.J. Renin-angiotensin-system gene polymorphisms and depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2007, 31:1113-1118.
50. Saavedra J.M., Sanchez-Lemus E., Benicky J. Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: therapeutic implications. Psychoneuroendocrinology 2011, 36:1-18.
51. Sanches M., Caetano S., Nicoletti M., Monkul E.S., Chen H.H., Hatch J.P., Yeh P.H., Mullis R.L., Keshavan M.S., Rajowska G., Soares J.C. An MRI-based approach for the measurement of the dorsolateral prefrontal cortex in humans. Psychiatry Research Neuroimaging 2009, 173:150-154.
52. Sierra C., Coca A., Gomez-Angelats E., Poch E., Sobrino J., de la Sierra A. Renin-angiotensin system genetic polymorphisms and cerebral white matter lesions in essential hypertension. Hypertension 2002, 39:343-347.
53. Sleegers K., den Heijer T., van Dijk E.J., Hofman A., Bertoli-Avella A.M., Koudstaal P.J., Breteler M.M., van Duijn C.M. ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala. Neurobiology of Aging 2005, 26:1153-1159.
54. Sparks D.L., Hunsaker J.C., Amouyel P., Malafosse A., Bellivier F., Leboyer M., Courtet P., Helbecque N. Angiotensin I-converting enzyme I/D polymorphism and suicidal behaviors. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 2009, 150B:290-294.
55. Spiering W., Kroon A.A., Fuss-Lejeune M.M., Daemen M.J., de Leeuw P.W. Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet. Hypertension 2000, 36:411-416.
56. Szolnoki Z., Somogyvari F., Kondacs A., Szabo M., Fodor L., Bene J., Melegh B. Specific APO E genotypes in combination with the ACE D/D or MTHFR 677TT mutation yield an independent genetic risk of leukoaraiosis. Acta Neurologica Scandinavica 2004, 109:222-227.
57. Takami S., Imai Y., Katsuya T., Ohkubo T., Tsuji I., Nagai K., Satoh H., Hisamichi S., Higaki J., Ogihara T. Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction. The Ohasama study. American Journal of Hypertension 2000, 13:121-127.
58. Taylor W.D., MacFall J.R., Payne M.E., McQuoid D.R., Steffens D.C., Provenzale J.M., Krishnan K.R. Greater MRI lesion volumes in elderly depressed subjects than in control subjects. Psychiatry Research Neuroimaging 2005, 139:1-7.
59. Taylor W.D., Steffens D.C., Ashley-Koch A., Payne M.E., MacFall J.R., Potocky C., Krishnan K.R. Angiotensin receptor gene polymorphisms and 2-year change in cerebral hyperintense lesion volume in men. Molecular Psychiatry 2010, 15:816-822.
60. Taylor W.D., Zhao Z., Ashley-Koch A., Payne M.E., Steffens D.C., Krishnan R.R., Hauser E., MacFall J.R. Fiber tract-specific white matter lesion severity findings in late-life depression and by AGTR1 A1166C genotype. Human Brain Mapping 2011, electronic publication 22 October; http://dx.doi.org/10.1002/hbm.21445.
61. Tsutsumi K., Saavedra J.M. Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain. American Journal of Physiology 1991, 261:R209-R216.
62. Van Leemput K., Maes F., Vandermeulen D., Suetens P. Automated model-based tissue classification of MR images of the brain. IEEE Transactions on Medical Imaging 1999, 18:897-908.
63. Van Leemput K., Maes F., Vandermeulen D., Colchester A., Suetens P. Automated segmentation of multiple sclerosis lesions by model outlier detection. IEEE Transactions on Medical Imaging 2001, 20:677-688.
64. Van Leemput K., Maes F., Vandermeulen D., Suetens P. A unifying framework for partial volume segmentation of brain MR images. IEEE Transactions on Medical Imaging 2003, 22:105-119.
65. van Rijn M.J., Bos M.J., Isaacs A., Yazdanpanah M., Arias-Vasquez A., Stricker B.H., Klungel O.H., Oostra B.A., Koudstaal P.J., Witteman J.C., Hofman A., Breteler M.M., van Duijn C.M. Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology. Journal of Neurology, Neurosurgery, and Psychiatry 2007, 78:1083-1087.
66. Zaykin D., Zhivotovsky L., Weir B.S. Exact tests for association between alleles at arbitrary numbers of loci. Genetica 1995, 96:169-178.
67. Zhang Z., Deng L., Bai F., Shi Y., Yu H., Yuan Y., Jiang T., Jia J. ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment. Behavioural Brain Research 2011, 218:114-120.