Treatment Deintensification Strategies for HPV-Associated Head and Neck Carcinomas

Otolaryngologic Clinics of North America

Volumn 45, Issue 4, 2012, Pages 845-861

  Quon, Harry ^a   Richmon, Jeremy D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

De intensification; HPV associated head and neck carcinoma; Late swallowing complications; Radiotherapy; Treatment complications; Treatment deintensfication

Indexed keywords

CETUXIMAB; CISPLATIN; PACLITAXEL;

BRACHYTHERAPY; CANCER CONTROL; CANCER PATIENT; COMPUTER ASSISTED RADIOTHERAPY; DOSIMETRY; DYSPHAGIA; ESOPHAGUS DISEASE; EXTERNAL BEAM RADIOTHERAPY; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LARYNX DISORDER; LOW DRUG DOSE; MORBIDITY; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; PATIENT SAFETY; RADIATION DOSE FRACTIONATION; REVIEW; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SURGICAL APPROACH; SURGICAL TECHNIQUE; TREATMENT INDICATION; TREATMENT OUTCOME; TREATMENT PLANNING; TREATMENT RESPONSE; WART VIRUS;

CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; DEGLUTITION DISORDERS; HEAD AND NECK NEOPLASMS; HUMANS; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; RADIATION DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED; RISK FACTORS;

EID: 84863872286     PISSN: 00306665     EISSN: 15578259     Source Type: Journal    
DOI: 10.1016/j.otc.2012.04.007     Document Type: Review

References (49)

1. Khariwala S.S., Vivek P.P., Lorenz R.R., et al. Swallowing outcomes after microvascular head and neck reconstruction: a prospective review of 191 cases. Laryngoscope 2007, 117(8):1359-1363.
2. Pignon J.P., Le Maître A., Bourhis J. Meta-analyses of chemotherapy in head and neck cancer (MACH-NC): an update. Int J Radiat Oncol Biol Phys 2007, 69(2 Suppl 1):S112-S114.
3. Bourhis J., Overgaard J., Audry H., et al. Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet 2006, 368(9538):843-854.
4. Machtay M., Moughan J., Trotti A., et al. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol 2008, 26(21):3582-3589.
5. Caudell J.J., Schaner P.E., Meredith R.F., et al. Factors associated with long-term dysphagia after definitive radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 2009, 73(2):410-415.
6. Langendijk J.A., Doornaert P., Rietveld D.H., et al. A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. Radiother Oncol 2009, 90(2):189-195.
7. Frowen J., Cotton S., Corry J., et al. Impact of demographics, tumor characteristics, and treatment factors on swallowing after (chemo) radiotherapy for head and neck cancer. Head Neck 2010, 32(4):513-528.
8. Fakhry C., Westra W.H., Li S., et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 2008, 100(4):261-269.
9. Gillison M.L., Harris J., Westra W., et al. Survival outcomes by tumor human papillomavirus (HPV) status in stage III-IV oropharyngeal cancer (OPC) in RTOG 0129. J Clin Oncol 2009, 27(15S):6003. [abstract].
10. Worden F.P., Hooton J., Lee J., et al. Association of tobacco (T) use with risk of distant metastases (DM), tumor recurrence, and death in patients (pts) with HPV-positive (+) squamous cell cancer of the oropharynx (SCCOP). J Clin Oncol 2009, 27(15S):6001. [Abstract].
11. Langendijk J.A., Doornaert P., Verdonck-de Leeuw I.M., et al. Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy. J Clin Oncol 2008, 26(22):3770-3776.
12. Gokhale A.S., McLaughlin B.T., Flickinger J.C., et al. Clinical and dosimetric factors associated with a prolonged feeding tube requirement in patients treated with chemoradiotherapy (CRT) for head and neck cancers. Ann Oncol 2010, 21(1):145-151.
13. Caudell J.J., Schaner P.E., Desmond R.A., et al. Dosimetric factors associated with long-term dysphagia after definitive radiotherapy for squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 2010, 76(2):403-409.
14. Dirix P., Abbeel S., Vanstraelen B., et al. Dysphagia after chemoradiotherapy for head-and-neck squamous cell carcinoma: dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys 2009, 75(2):385-392.
15. O'Meara E.A., Machtay M., Moughan J., et al. Associations between radiation doses to pharyngeal regions and severe late toxicity in head and neck cancer patients treated with concurrent chemoradiotherapy-an RTOG analysis. Int J Radiat Oncol Biol Phys 2007, 69(Suppl 3):S54-S55.
16. Agarwal J., Dutta D., Palwe V., et al. Prospective subjective evaluation of swallowing function and dietary pattern in head and neck cancers treated with concomitant chemo-radiation. J Cancer Res Ther 2010, 6(1):15-21.
17. Poulsen M.G., Riddle B., Keller J., et al. Predictors of acute grade 4 swallowing toxicity in patients with stages III and IV squamous carcinoma of the head and neck treated with radiotherapy alone. Radiother Oncol 2008, 87(2):253-259.
18. Bhide S.A., Gulliford S., Fowler J., et al. Characteristics of response of oral and pharyngeal mucosa in patients receiving chemo-IMRT for head and neck cancer using hypofractionated accelerated radiotherapy. Radiother Oncol 2010, 97(1):86-91.
19. Logemann J.A., Smith C.H., Pauloski B.R., et al. Effects of xerostomia on perception and performance of swallow function. Head Neck 2001, 23(4):317-321.
20. Logemann J.A., Pauloski B.R., Rademaker A.W., et al. Xerostomia: 12-month changes in saliva production and its relationship to perception and performance of swallow function, oral intake, and diet after chemoradiation. Head Neck 2003, 25(6):432-437.
21. Popovtzer A., Cao Y., Feng F.Y., et al. Anatomical changes in the pharyngeal constrictors after chemo-irradiation of head and neck cancer and their dose-effect relationships: MRI-based study. Radiother Oncol 2009, 93(3):510-515.
22. Dornfeld K., Hopkins S., Simmons J., et al. Posttreatment FDG-PET uptake in the supraglottic and glottic larynx correlates with decreased quality of life after chemoradiotherapy. Int J Radiat Oncol Biol Phys 2008, 71(2):386-392.
23. Feng F.Y., Kim H.M., Lyden T.H., et al. Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys 2007, 68(5):1289-1298.
24. Levendag P.C., Teguh D.N., Voet P., et al. Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship. Radiother Oncol 2007, 85(1):64-73.
25. Jensen K., Lambertsen K., Grau C. Late swallowing dysfunction and dysphagia after radiotherapy for pharynx cancer: frequency, intensity and correlation with dose and volume parameters. Radiother Oncol 2007, 85(1):74-82.
26. Caglar H.B., Tishler R.B., Othus M., et al. Dose to larynx predicts for swallowing complications after intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 2008, 72(4):1110-1118.
27. Rancati T., Schwarz M., Allen A.M., et al. Radiation dose-volume effects in the larynx and pharynx. Int J Radiat Oncol Biol Phys 2010, 76(Suppl 3):S64-S69.
28. Ang K.K., Trotti A., Brown B.W., et al. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 2001, 51(3):571-578.
29. Smith R.V., Goldman S.Y., Beitler J.J., et al. Problems with altered radiotherapy dosing used in an organ-sparing protocol for advanced pharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 2004, 130(7):831-836.
30. Skladowski K., Maciejewski B., Golen M., et al. Randomized clinical trial on 7-day-continuous accelerated irradiation (CAIR) of head and neck cancer - report on 3-year tumour control and normal tissue toxicity. Radiother Oncol 2000, 55(2):101-110.
31. Skladowski K., Maciejewski B., Golen M., et al. Continuous accelerated 7-days-a-week radiotherapy for head-and-neck cancer: long-term results of phase III clinical trial. Int J Radiat Oncol Biol Phys 2006, 66(3):706-713.
32. Lauve A., Morris M., Schmidt-Ullrich R., et al. Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: II-clinical results. Int J Radiat Oncol Biol Phys 2004, 60(2):374-387.
33. Koiwai K., Shikama N., Sasaki S., et al. Risk factors for severe Dysphagia after concurrent chemoradiotherapy for head and neck cancers. Jpn J Clin Oncol 2009, 39(7):413-417.
34. Quon H., Leong T., Haselow R., et al. Phase III study of radiation therapy with or without cis-platinum in patients with unresectable squamous or undifferentiated carcinoma of the head and neck: an intergroup trial of the Eastern Cooperative Oncology Group (E2382). Int J Radiat Oncol Biol Phys 2011, 81(3):719-725.
35. Bonner J.A., Harari P.M., Giralt J., et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006, 354(6):567-578.
36. Bonner J.A., Harari P.M., Giralt J., et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 2010, 11(1):21-28.
37. Lango M., Ende K., Ahmad S., et al. Neck dissection following organ preservation protocols prolongs feeding tube dependence in patients with advanced head and neck cancer. J Clin Oncol (ASCO Meeting Abstracts) 2006, 24(Suppl 18):5525.
38. Graner D.E., Foote R.L., Kasperbauer J.L., et al. Swallow function in patients before and after intra-arterial chemoradiation. Laryngoscope 2003, 113(3):573-579.
39. Chapuy C.I., Annino D.J., Snavely A., et al. Swallowing function following postchemoradiotherapy neck dissection: review of findings and analysis of contributing factors. Otolaryngol Head Neck Surg 2011, 145(3):428-434.
40. Carroll W.R., Locher J.L., Canon C.L., et al. Pretreatment swallowing exercises improve swallow function after chemoradiation. Laryngoscope 2008, 118(1):39-43.
41. Ames J.A., Karnell L.H., Gupta A.K., et al. Outcomes after the use of gastrostomy tubes in patients whose head and neck cancer was managed with radiation therapy. Head Neck 2011, 33(5):638-644.
42. Dosoretz A, Dutta PR, Lin A, et al, editors. Long-term percutaneous gastrostomy tube dependence rates in patients treated with intensity-modulated radiotherapy for oropharyngeal cancer: the University of Pennsylvania Experience. ASTRO Head and Neck Symposium. Chandler (AZ); 2009.
43. Peponi E., Glanzmann C., Willi B., et al. Dysphagia in head and neck cancer patients following intensity modulated radiotherapy (IMRT). Radiat Oncol 2011, 6:1.
44. Moore E.J., Olsen K.D., Kasperbauer J.L. Transoral robotic surgery for oropharyngeal squamous cell carcinoma: a prospective study of feasibility and functional outcomes. Laryngoscope 2009, 119(11):2156-2164.
45. Holsinger F.C., McWhorter A.J., Menard M., et al. Transoral lateral oropharyngectomy for squamous cell carcinoma of the tonsillar region: I. Technique, complications, and functional results. Arch Otolaryngol Head Neck Surg 2005, 131(7):583-591.
46. Bernier J., Domenge C., Ozsahin M., et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 2004, 350(19):1945-1952.
47. Cooper J.S., Pajak T.F., Forastiere A.A., et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 2004, 350(19):1937-1944.
48. Weinstein G.S., Quon H., O'Malley B.W., et al. Selective neck dissection and de-intensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania TORS trial. Laryngoscope 2010, 120(9):1749-1755.
49. O'Sullivan B., Warde P., Grice B., et al. The benefits and pitfalls of ipsilateral radiotherapy in carcinoma of the tonsillar region. Int J Radiat Oncol Biol Phys 2001, 51(2):332-343.