Impact of adrenal versus ovarian androgen ratio on signs and symptoms of polycystic ovarian syndrome

Gynecological Endocrinology

Volumn 28, Issue 8, 2012, Pages 611-614

  Köşüş, Nermin ^a   Köşüş, Aydin ^a   Kamalak, Zeynep ^a   Hizli, Deniz ^a   Turhan, Nilgün Ö ^a,b  

^a FATIH UNIVERSITY   (Turkey)

^b MUGLA SITKI KOCMAN UNIVERSITY   (Turkey)

Author keywords

Body mass index; DHEAS; lipid profile; PCOS; total testosterone; waist circumference

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CORTICOTROPIN; ESTRADIOL; FOLLITROPIN; GAMMA GLUTAMYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROCORTISONE; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; PRASTERONE SULFATE; PROGESTERONE; TESTOSTERONE; TRIACYLGLYCEROL; AUTACOID;

ACNE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANDROGEN BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL FEATURE; CORTICOTROPIN BLOOD LEVEL; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HIRSUTISM; HUMAN; HUMAN TISSUE; HYDROCORTISONE BLOOD LEVEL; INSULIN RESISTANCE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; OVARY POLYCYSTIC DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; TESTOSTERONE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; ACNE VULGARIS; ADOLESCENT; ALGORITHM; AMENORRHEA; BLOOD; HYPERANDROGENISM; HYPERLIPIDEMIA; IMMUNOLOGY; INCIDENCE; METABOLISM; OBESITY; OLIGOMENORRHEA; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; TURKEY (REPUBLIC);

ACNE VULGARIS; ADOLESCENT; ADULT; ALGORITHMS; AMENORRHEA; BODY MASS INDEX; DEHYDROEPIANDROSTERONE SULFATE; FEMALE; HIRSUTISM; HUMANS; HYPERANDROGENISM; HYPERLIPIDEMIAS; INCIDENCE; INFLAMMATION MEDIATORS; INSULIN RESISTANCE; OBESITY; OLIGOMENORRHEA; POLYCYSTIC OVARY SYNDROME; SEVERITY OF ILLNESS INDEX; TESTOSTERONE; TURKEY; YOUNG ADULT;

EID: 84863869933     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2011.650770     Document Type: Article

References (34)

1. Walker JJ. Pre-eclampsia. Lancet 2000;356:1260-1265.
2. Saftlas AF, Olson DR, Franks AL, Atrash HK, Pokras R. Epidemiology of preeclampsia and eclampsia in the United States, 1979-1986. Am J Obstet Gynecol 1990;163:460-465.
3. Borekci B, Aksoy H, Al RA, Demircan B, Kadanali S. Maternal serum interleukin-10, interleukin-2 and interleukin-6 in pre-eclampsia and eclampsia. Am J Reprod Immunol 2007;58:56-64.
4. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science 2005;308:1592-1594.
5. Djurovic S, Clausen T, Wergeland R, Brosstad F, Berg K, Henriksen T. Absence of enhanced systemic inflammatory response at 18 weeks of gestation in women with subsequent pre-eclampsia. BJOG 2002;109:759-764.
6. Roberts JM, Taylor RN, Goldfien A. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am J Hypertens 1991;4:700-708.
7. Conrad KP, Benyo DF. Placental cytokines and the pathogenesis of preeclampsia. Am J Reprod Immunol 1997;37:240-249.
8. Omu AE, Makhseed M, al-Qattan F. The comparative value of interleukin-4 in sera of women with preeclampsia and cord sera. Nutrition 1995;11:688-691.
9. Al-Othman S, Omu AE, Diejomaoh FM, Al-Yatama M, Al-Qattan F. Differential levels of interleukin 6 in maternal and cord sera and placenta in women with pre-eclampsia. Gynecol Obstet Invest 2001;52:60-65.
10. Redman CW, Sargent IL. Pre-eclampsia, the placenta and the maternal systemic inflammatory response-a review. Placenta 2003;24 Suppl A:S21-S27.
11. Redman CW, Sacks GP, Sargent IL. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999;180:499-506.
12. Akira S, Taga T, Kishimoto T. Interleukin-6 in biology and medicine. Adv Immunol 1993;54:1-78.
13. Saito S. Cytokine network at the feto-maternal interface. J Reprod Immunol 2000;47:87-103.
14. Greer IA, Lyall F, Perera T, Boswell F, Macara LM. Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction? Obstet Gynecol 1994;84:937-940.
15. Conrad KP, Miles TM, Benyo DF. Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol 1998;40:102-111.
16. Hayashi M, Ueda Y, Ohkura T, Inaba N. Interleukin-6 concentrations in the placenta and blood in normal pregnancies and preeclampsia. Horm Metab Res 2005;37:419-424.
17. Report of the National High Blood Pressure Education Program Working Group. Report on high blood pressure in pregnancy. Am J Obstet Gynecol 2000;183:1-22.
18. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol 2003;102:181-192.
19. Tracy RP. Inflammation in cardiovascular disease: cart, horse, or both? Circulation 1998;97:2000-2002.
20. Tedgui A, Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev 2006;86:515-581.
21. Cioffi M, Esposito K, Vietri MT, Gazzerro P, D'Auria A, Ardovino I, Puca GA, Molinari AM. Cytokine pattern in postmenopause. Maturitas 2002;41:187-192.
22. Yasui T, Maegawa M, Tomita J, Miyatani Y, Yamada M, Uemura H, Matsuzaki T, et al. Changes in serum cytokine concentrations during the menopausal transition. Maturitas 2007;56:396-403.
23. Schwartz RB, Feske SK, Polak JF, DeGirolami U, Iaia A, Beckner KM, Bravo SM, et al. Preeclampsia-eclampsia: clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy. Radiology 2000;217:371-376.
24. Kalinderis M, Papanikolaou A, Kalinderi K, Ioannidou E, Giannoulis C, Karagiannis V, Tarlatzis BC. Elevated serum levels of interleukin-6, interleukin-1β and human chorionic gonadotropin in pre-eclampsia. Am J Reprod Immunol 2011;66:468-475.
25. Vince GS, Starkey PM, Austgulen R, Kwiatkowski D, Redman CW. Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia. Br J Obstet Gynaecol 1995;102:20-25.
26. Tosun M, Celik H, Avci B, Yavuz E, Alper T, Malatyalioglu E. Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia. J Matern Fetal Neonatal Med 2010;23:880-886.
27. Tarnowska-Madra U, Leibschang J, Kowalska B, Filipp E, Kozar A, Nimer A, Maciejewski T. [Levels of immunoreactive cytokines in serum of women with preeclampsia or severe pregnancy hypertension]. Ginekol Pol 2010;81:192-196.
28. Dudley DJ, Trautman MS, Araneo BA, Edwin SS, Mitchell MD. Decidual cell biosynthesis of interleukin-6: regulation by inflammatory cytokines. J Clin Endocrinol Metab 1992;74:884-889.
29. Nishino E, Matsuzaki N, Masuhiro K, Kameda T, Taniguchi T, Takagi T, Saji F, Tanizawa O. Trophoblast-derived interleukin-6 (IL-6) regulates human chorionic gonadotropin release through IL-6 receptor on human trophoblasts. J Clin Endocrinol Metab 1990;71:436-441.
30. Lewis DF, Canzoneri BJ, Wang Y. Maternal circulating TNF-alpha levels are highly correlated with IL-10 levels, but not IL-6 and IL-8 levels, in women with pre-eclampsia. Am J Reprod Immunol 2009;62:269-274.
31. Vural P, Degirmencioglu S, Saral NY, Demirkan A, Akgul C, Yildirim G, Issever H, Eroglu H. Tumor necrosis factor alpha, interleukin-6 and interleukin-10 polymorphisms in preeclampsia. J Obstet Gynaecol Res 2010;36:64-71.
32. Daher S, Sass N, Oliveira LG, Mattar R. Cytokine genotyping in preeclampsia. Am J Reprod Immunol 2006;55:130-135.
33. Stonek F, Hafner E, Metzenbauer M, Katharina S, Stümpflen I, Schneeberger C, Zeisler H, et al. Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia. J Reprod Immunol 2008;77:85-90.
34. Saarela T, Hiltunen M, Helisalmi S, Heinonen S, Laakso M. Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia. Eur J Obstet Gynecol Reprod Biol 2006;128:175-179.