Testosterone and aggressive behavior in man

International Journal of Endocrinology and Metabolism

Volumn 10, Issue 3, 2012, Pages 563-568

  Batrinos, Menelaos L ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Aggressiveness; Cortisol; Serotonin; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; GONADORELIN; HYDROCORTISONE; SEROTONIN; TESTOSTERONE; ANDROSTANOLONE; DNA; ESTRADIOL RECEPTOR; LUTEINIZING HORMONE; NEUROTRANSMITTER; SEROTONIN RECEPTOR;

AGGRESSIVENESS; AMYGDALOID NUCLEUS; ANDROGEN RECEPTOR GENE; CAG REPEAT; EMOTION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE EXPRESSION REGULATION; HORMONE RELEASE; HUMAN; HYPOTHALAMUS; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; RECEPTOR GENE; REVIEW; TESTOSTERONE BLOOD LEVEL; VIOLENCE; AGGRESSION; ANGER; COGNITION; ELECTROENCEPHALOGRAM; NEUROENDOCRINE SYSTEM; SEROTONIN BLOOD LEVEL; TEMPORAL LOBE; TRAUMATIC BRAIN INJURY;

EID: 84863869593     PISSN: 1726913X     EISSN: 17269148     Source Type: Journal    
DOI: 10.5812/ijem.3661     Document Type: Review

References (42)

1. Archer J Testosterone and human aggression: an evaluation of the challenge hypothesis. Neurosci Biobehav Rev. 2006;30(3):319-45.
2. Book AS, Starzyk KB, Quinsey VL. The relationship between testosterone and aggression: A meta-analysis. Aggression and Violent Behavior. 2001;6(6):579-99.
3. Carre JM, McCormick CM, Hariri AR. The social neuroendocrinology of human aggression. Psychoneuroendocrinology. 2011;36(7):935-44.
4. Christiansen K. Behavioural correlates of testosterone. Testosterone, Action, Deficiency, Substitution Springer Verlag. 2004:125-71.
5. Georgiadis EI, Matzoros C, Aliferis C, Batrinos M. Are adrenal and testicular androgen levels correlated? Horm Metab Res. 1992;24(10):488-91.
6. Giammanco M, Tabacchi G, Giammanco S, Di Majo D, La Guardia M. Testosterone and aggressiveness. Med Sci Monit. 2005;11(4):RA136-45.
7. Negri-Cesi P, Colciago A, Celotti F, Motta M. Sexual differentiation of the brain: role of testosterone and its active metabolites. J Endocrinol Invest. 2004;27(6 Suppl):120-7.
8. Panitsa-Faflia C, Batrinos ML. Late-onset congenital adrenal hyperplasia. Ann N Y Acad Sci. 1997;816:230-4.
9. Rinieris PM, Malliaras DE, Batrinos ML, Stefanis CN. Testosterone treatment of depression in two patients with Klinefelter's syndrome. Am J Psychiatry. 1979;136(7):986-8.
10. Soma KK, Scotti MA, Newman AE, Charlier TD, Demas GE. Novel mechanisms for neuroendocrine regulation of aggression. Front Neuroendocrinol. 2008;29(4):476-89.
11. Terburg D, Morgan B, van Honk J. The testosterone-cortisol ratio: A hormonal marker for proneness to social aggression. Int J Law Psychiatry. 2009;32(4):216-23.
12. Zitzmann M. Testosterone and the brain. Aging Male. 2006;9(4):195-9.
13. Kreuz LE, Rose RM. Assessment of aggressive behavior and plasma testosterone in a young criminal population. Psychosom Med. 1972;34(4):321-32.
14. Dabbs Jr.JM, Frady RL, Carr TS, Besch NF. Saliva testosterone and criminal violence in young adult prison inmates. Psychosom Med. 1987;49(2):174-82.
15. Chichinadze KN, Domianidze TR, Matitaishvili T, Chichinadze NK, Lazarashvili AG. Possible relation of plasma testosterone level to aggressive behavior of male prisoners. Bull Exp Biol Med. 2010;149(1):7-9.
16. Ehrenkranz J, Bliss E, Sheard MH. Plasma testosterone: correlation with aggressive behavior and social dominance in man. Psychosom Med. 1974;36(6):469-75.
17. Aromaki AS, Lindman RE, Eriksson CJ. Testosterone, sexuality and antisocial personality in rapists and child molesters: a pilot study. Psychiatry Res. 2002;110(3):239-47.
18. Giotakos O, Markianos M, Vaidakis N, Christodoulou GN. Aggression, impulsivity, plasma sex hormones, and biogenic amine turnover in a forensic population of rapists. J Sex Marital Ther. 2003;29(3):215-25.
19. Mazur A. Biosocial models of deviant behavior among male army veterans. Biol Psychol. 1995;41(3):271-93.
20. O'Connor DB, Archer J, Hair WM, Wu FC. Exogenous testosterone, aggression, and mood in eugonadal and hypogonadal men. Physiol Behav. 2002;75(4):557-66.
21. Tricker R, Casaburi R, Storer TW, Clevenger B, Berman N, Shirazi A, et al. The effects of supraphysiological doses of testosterone on angry behavior in healthy eugonadal men-a clinical research center study. J Clin Endocrinol Metab. 1996;81(10):3754-8.
22. Edwards DA. Competition and testosterone. Horm Behav. 2006;50(5):681-3.
23. Aluja A, Torrubia R. Hostility-aggressiveness, sensation seeking, and sex hormones in men: re-exploring their relationship. Neuropsychobiology. 2004;50(1):102-7.
24. Carre JM, Putnam SK. Watching a previous victory produces an increase in testosterone among elite hockey players. Psychoneuroendocrinology. 2010;35(3):475-9.
25. Stanton SJ, Beehner JC, Saini EK, Kuhn CM, Labar KS. Dominance, politics, and physiology: voters' testosterone changes on the night of the 2008 United States presidential election. PLoS One. 2009;4(10):e7543.
26. Booth A, Shelley G, Mazur A, Tharp G, Kittok R. Testosterone, and winning and losing in human competition. Horm Behav. 1989;23(4):556-71.
27. Bernhardt PC, Dabbs JM, Jr., Fielden JA, Lutter CD. Testosterone changes during vicarious experiences of winning and losing among fans at sporting events. Physiol Behav. 1998;65(1):59-62.
28. Carre JM, McCormick CM. Aggressive behavior and change in salivary testosterone concentrations predict willingness to engage in a competitive task. Horm Behav. 2008;54(3):403-9.
29. Carre JM, Putnam SK, McCormick CM. Testosterone responses to competition predict future aggressive behaviour at a cost to reward in men. Psychoneuroendocrinology. 2009;34(4):561-70.
30. van Bokhoven I, van Goozen SH, van Engeland H, Schaal B, Arseneault L, Seguin JR, et al. Salivary testosterone and aggression, delinquency, and social dominance in a population-based longitudinal study of adolescent males. Horm Behav. 2006;50(1):118-25.
31. Michels G, Hoppe UC. Rapid actions of androgens. Front Neuroendocrinol. 2008;29(2):182-98.
32. Bufkin JL, Luttrell VR. Neuroimaging studies of aggressive and violent behavior: current findings and implications for criminology and criminal justice. Trauma Violence Abuse. 2005;6(2):176-91.
33. Brown GL, McGarvey EL, Shirtcliff EA, Keller A, Granger DA, Flavin K. Salivary cortisol, dehydroepiandrosterone, and testosterone interrelationships in healthy young males: a pilot study with implications for studies of aggressive behavior. Psychiatry Res. 2008;159(1-2):67-76.
34. Mehta PH, Josephs RA. Testosterone and cortisol jointly regulate dominance: evidence for a dual-hormone hypothesis. Horm Behav. 2010;58(5):898-906.
35. Kuepper Y, Alexander N, Osinsky R, Mueller E, Schmitz A, Netter P, et al. Aggression-interactions of serotonin and testosterone in healthy men and women. Behav Brain Res. 2010;206(1):93-100.
36. van Wingen GA, Ossewaarde L, Backstrom T, Hermans EJ, Fernandez G. Gonadal hormone regulation of the emotion circuitry in humans. Neuroscience. 2011;191:38-45.
37. Birger M, Swartz M, Cohen D, Alesh Y, Grishpan C, Kotelr M. Aggression: the testosterone-serotonin link. Isr Med Assoc J. 2003;5(9):653-8.
38. Witte AV, Floel A, Stein P, Savli M, Mien LK, Wadsak W, et al. Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects. Hum Brain Mapp. 2009;30(8):2558-70.
39. Derntl B, Windischberger C, Robinson S, Kryspin-Exner I, Gur RC, Moser E, et al. Amygdala activity to fear and anger in healthy young males is associated with testosterone. Psychoneuroendocrinology. 2009;34(5):687-93.
40. Rajender S, Pandu G, Sharma JD, Gandhi KP, Singh L, Thangaraj K. Reduced CAG repeats length in androgen receptor gene is associated with violent criminal behavior. Int J Legal Med. 2008;122(5):367-72.
41. Manuck SB, Marsland AL, Flory JD, Gorka A, Ferrell RE, Hariri AR. Salivary testosterone and a trinucleotide (CAG) length polymorphism in the androgen receptor gene predict amygdala reactivity in men. Psychoneuroendocrinology. 2010;35(1):94-104.
42. Craig IW, Halton KE. Genetics of human aggressive behaviour. Hum Genet. 2009;126(1):101-13.