Hepatoprotective role of milk thistle (Silybum marianum) in meat type chicken fed aflatoxin B1 contaminated feed

Pakistan Veterinary Journal

Volumn 32, Issue 3, 2012, Pages 443-446

  Muhammad, Din ^a   Chand, Naila ^a   Khan, Sarzamin ^a   Sultan, Asad ^a   Mushtaq, Mohammad ^a   Rafiullah, ^a  

^a THE UNIVERSITY OF AGRICULTURE   (Pakistan)

Author keywords

Aflatoxin B1; Broilers; Liver functions tests; Milk thistle; Toxin binder

Indexed keywords

AVES; SILYBUM MARIANUM;

EID: 84863868949     PISSN: 02538318     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Abenavoli L, G Aviello, R Capasso, N Milic and F Capasso, 2011. Milk thistle for treatment of nonalcoholic fatty liver disease. Hepat Mon, 11: 173-177.
2. Ahsan S, IA Bhatti, MR Asi, HN Bhatti and MA Sheikh, 2010. Occurrence of aflatoxins in maize grains from central areas of Punjab, Pakistan. Int J Agric Biol, 12: 571-575.
3. Anonymous, 1984. Manual of veterinary investigation laboratory techniques Volume 2, Reference Book 390. Ministry of Agriculture, Fisheries and Food, HMSO London, UK, pp:12, 49, 72.
4. Asim A, KNM Khan, AH Cheema, FA Mir and M Afzal, 1990. Occurrence of aflatoxins in poultry liver and associated pathological changes. Pak Vet J, 10: 51-54.
5. Dhiman RK and YK Chawal, 2005. Herbal medicines for liver diseases. Dig Dis Sci, 50: 1807-1812.
6. Denli M and F Okan, 2006. Efficacy of different adsorbents in reducing the toxic effects of aflatoxin B1 in broiler diets. South Afr J Anim Sci, 36: 222-228
7. Ghani MU, 2007. Effect of liquorice (Glycyrrhiza glabra) root extract as immunostimulant hypocholesterolaemic hepatoprotective anticoccidial and growth promotant in broiler chicks. M Sc Thesis, KPK Agric Univ, Peshawar, Pakistan.
8. Grizzle J, J Wiles and R Benyard, 1999. In vitro Screening of Nutriceuticals for Immunosupport in avians. J Poult Sci, 71: 1577-1580.
9. Hassan ZU, 2010. Pathological responses of progeny of hens kept on ochratoxin A contaminated feed. PhD Thesis, Pathol, Univ of Agric, Faisalabad, Pakistan.
10. Hussain Z, MZ Khan and ZU Hassan, 2008. Production of aflatoxins from aspergillus flavus and acute aflatoxicosis in young broiler chicks. Pak J Agric Sci, 45: 95-102.
11. Janice P, EJ Ladas and KM Kelly, 2007. Advances in the Use of Milk Thistle (Silybum marianum). Integr Cancer Ther, 6: 104-109.
12. Kalorey DR, NV kurkure, IS Ramgaonkar, PS Sakhare, S Warke and NK Nigot, 2005. Effect of polyherbal feed supplement "growell" during induced aflatoxicosis, ochratoxicosis and combined mycotoxicoses in broilers. Asian-Aust J Anim Sci, 18: 375-383.
13. Khan WA, 2010. Pathological studies of aflatoxicosis on layer breeders and its subsequent effects on progeny. PhD Thesis, Pathol, Univ of Agric, Faisalabad, Pakistan.
14. Khan MM, 2007. Hematological hypolipidemic hypoglycemic anticoccidial hepatoprotective immunostimulant and growth promotant effect of Withania somnifera in broiler production. M Sc Thesis, KPK Agric Univ, Peshawar, Pakistan.
15. Ludovico A, R Capasso, N Milic and F Capasso, 2010. Milk thistle in liver diseases: past, present, future. Phytother Res, 24: 1423-1432.
16. Pradhan SC and C Girish, 2006. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res, 124: 491-504.
17. Rahim, M Siddique, STAK Sindhu and MA Khan, 1999. Immunomodulatory and growth-inhibitory effects of mycotoxins (aflatoxin B1) in broiler chicken and the reversal influence of hydrated sodium calcium aluminosilicate. Pak J Biol Sci, 2: 1027-1029.
18. Sabri MA, M Siddique, MZ Khan and HA Samad, 1989. Prevalence and pathology of mycotoxicosis in young broiler chicks in and around Faisalabad. Pak Vet J, 9: 106-108.
19. SAS, 1998. SAS user's guide: statistics. SAS Institute, Inc, Cary, NC.
20. Simanek V, V Kren, J Ulrihova, J Vicar and L Cvak, 2000. New application of Silybin and Silynarin. Hepatology, 32: 442.
21. Tedesco D, C Domeneghini, D Sciannimanico, M Tameni, S Steidler and S Galletti, 2004. Efficacy of silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks. J Poult Sci, 83: 1839-1843.
22. Thyagarajan S, S Jayaram, V Gopalakrishnan, R Hari, P Jeyakumar and M Sripathi, 2002. Herbal medicines for liver diseases in India. J Gastroente Hepat, 17: S370-S376.
23. Wang X, E Gocek, V Novik, JS Harrison, M Danilenko and GP Studzinski, 2010. Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3). Cell Cycle, 9: 4542-4551.