Modulation of aldehyde dehydrogenase activity affects (±)-4-hydroxy- 2E-nonenal (HNE) toxicity and HNE-protein adduct levels in PC12 cells

Journal of Molecular Neuroscience

Volumn 47, Issue 3, 2012, Pages 595-603

  Kong, Dehe ^a   Kotraiah, Vinayaka ^a  

^a Exonhit Inc   (United States)

Author keywords

Neuronal cell death; Neurotoxicity; Oxidative stress; Parkinson's disease; PC12

Indexed keywords

4 HYDROXYNONENAL; 6 METHYL 2 PHENYLAZO 3 PYRIDINOL; ALDEHYDE DEHYDROGENASE; DISULFIRAM;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL STRAIN; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS;

ALDEHYDES; ANIMALS; CELL DEATH; DISULFIRAM; DNA ADDUCTS; LIPID PEROXIDATION; OXIDATIVE STRESS; PARKINSON DISEASE; PC12 CELLS; RATS; RETINAL DEHYDROGENASE;

EID: 84863867764     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9688-y     Document Type: Article

References (27)

1. Awasthi YC, Ansari GA, Awasthi S (2005) Regulation of 4- hydroxynonenal mediated signaling by glutathione S-transferases. Methods Enzymol 401:379-407 (Pubitemid 43052405)
2. Black W, Vasiliou V (2009) The aldehyde dehydrogenase gene superfamily resource center. Hum Genomics 4:136-142
3. Bossy-Wetzel E, Schwarzenbacher R, Lipton SA (2004) Molecular pathways to neurodegeneration. Nat Med 10(Suppl):S2-S9 (Pubitemid 38901861)
4. Chen JJ, Yu BP (1994) Alterations in mitochondrial membrane fluidity by lipid peroxidation products. Free Radic Biol Med 17:411-418 (Pubitemid 24320290)
5. Cho ES, Jang YJ, Kang NJ et al (2009) Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. Free Radic Biol Med 46:1319-1327
6. Galter D, Buervenich S, Carmine A, Anvret M, Olson L (2003) ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia. Neurobiol Dis 14:637-647 (Pubitemid 37547970)
7. Jang YJ, Kim JE, Kang NJ, Lee KW, Lee HJ (2009) Piceatannol attenuates 4-hydroxynonenal-induced apoptosis of PC12 cells by blocking activation of c-Jun N-terminal kinase. Ann N YAcad Sci 1171:176-182
8. Jang YJ, Kim J, Shim J et al (2011) Kaempferol attenuates 4- hydroxynonenal-induced apoptosis in PC12 cells by directly inhibiting NADPH oxidase. J Pharmacol Exp Ther 337:747-754
9. Lam JP, Mays DC, Lipsky JJ (1997) Inhibition of recombinant human mitochondrial and cytosolic aldehyde dehydrogenases by two candidates for the active metabolites of disulfiram. Biochemistry 36:13748-13754 (Pubitemid 27481625)
10. Lamensdorf I, Eisenhofer G, Harvey-White J, Hayakawa Y, Kirk K, Kopin IJ (2000a) Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde. J Neurosci Res 60:552-558 (Pubitemid 30252918)
11. Lamensdorf I, Eisenhofer G, Harvey-White J, Nechustan A, Kirk K, Kopin IJ (2000b) 3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells. Brain Res 868:191-201 (Pubitemid 30347515)
12. Laplane D, Attal N, Sauron B, de Billy A, Dubois B (1992) Lesions of basal ganglia due to disulfiram neurotoxicity. J Neurol Neurosurg Psychiatry 55:925-929
13. Legros H, Dingeval MG, Janin F, Costentin J, Bonnet JJ (2004) Toxicity of a treatment associating dopamine and disulfiram for catecholaminergic neuroblastoma SH-SY5Y cells: relationships with 3,4-dihydroxyphenylacetaldehyde formation. Neurotoxicology 25:365-375 (Pubitemid 38283541)
14. Leonarduzzi G, Robbesyn F, Poli G (2004) Signaling kinases modulated by 4-hydroxynonenal. Free Radic Biol Med 37:1694-1702 (Pubitemid 39445371)
15. Mandel S, Grunblatt E, Riederer P et al (2005) Gene expression profiling of sporadic Parkinson's disease substantia nigra pars compacta reveals impairment of ubiquitin-proteasome subunits, SKP1A, aldehyde dehydrogenase, and chaperone HSC-70. Ann N Y Acad Sci 1053:356-375 (Pubitemid 43031116)
16. Omata Y, Saito Y, Fujita K et al (2008) Induction of adaptive response and enhancement of PC12 cell tolerance by lipopolysaccharide primarily through the upregulation of glutathione S-transferase A3 via Nrf2 activation. Free Radic Biol Med 45:1437-1445
17. Raza H, John A (2006) 4-Hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione Stransferase A4-4 and cytochrome P450 2E1 in PC12 cells. Toxicol Appl Pharmacol 216:309-318 (Pubitemid 44466011)
18. Ruef J, Rao GN, Li F et al (1998) Induction of rat aortic smooth muscle cell growth by the lipid peroxidation product 4- hydroxy-2-nonenal. Circulation 97:1071-1078
19. Samii A, Nutt JG, Ransom BR (2004) Parkinson's disease. Lancet 363:1783-1793 (Pubitemid 38698383)
20. Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA (1997) 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem 68:2092-2097 (Pubitemid 27176147)
21. Schaur RJ (2003) Basic aspects of the biochemical reactivity of 4- hydroxynonenal. Mol Aspects Med 24:149-159
22. Siems W, Grune T (2003) Intracellular metabolism of 4-hydroxynonenal. Mol Aspects Med 24:167-175 (Pubitemid 36945017)
23. Subramaniam R, Roediger F, Jordan B et al (1997) The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins. J Neurochem 69:1161-1169 (Pubitemid 27364837)
24. Werner CJ, Heyny-von HR, Mall G,Wolf S (2008) Proteome analysis of human substantia nigra in Parkinson's disease. Proteome Sci 6:8
25. Yang Y, Sharma R, Sharma A, Awasthi S, Awasthi YC (2003) Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. Acta Biochim Pol 50:319-336 (Pubitemid 37034689)
26. Yoritaka A, Hattori N, Uchida K, Tanaka M, Stadtman ER, Mizuno Y (1996) Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc Natl Acad Sci U S A 93:2696-2701 (Pubitemid 26114311)
27. Zhang M, Shoeb M, Goswamy J et al (2010) Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells. J Neurosci Res 88:686-694