Maternal serum interleukin-6 and its association with clinicopathological infectious morbidity in preterm premature rupture of membranes: A prospective cohort study

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 25, Issue 8, 2012, Pages 1428-1432

  Gulati, Shilpa ^a   Agrawal, Swati ^a   Raghunandan, Chitra ^a   Bhattacharya, Jayashree ^a   Saili, Arvind ^a   Agarwal, Shilpi ^a   Sharma, Deepika ^a  

^a LADY HARDINGE MEDICAL COLLEGE   (India)

Author keywords

Chorioamnionitis; cytokines; ELISA; funisitis; neonatal sepsis

Indexed keywords

AMOXICILLIN; AMPICILLIN; BETAMETHASONE; C REACTIVE PROTEIN; INTERLEUKIN 6;

ADULT; ARTICLE; ASYMPTOMATIC INFECTION; CHORIOAMNIONITIS; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; FEMALE; FETUS; FETUS OUTCOME; FUNISITIS; GESTATION PERIOD; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERLEUKIN 6 BLOOD LEVEL; INTRAUTERINE INFECTION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MATERNAL BLOOD; MATERNAL MORBIDITY; MORBIDITY; NEWBORN; NEWBORN SEPSIS; PLACENTA; PREGNANCY OUTCOME; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PUERPERAL FEVER; PUERPERIUM; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; SEPSIS; UMBILICAL CORD;

ADULT; COHORT STUDIES; FEMALE; FETAL MEMBRANES, PREMATURE RUPTURE; HUMANS; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; INFECTION; INTERLEUKIN-6; MORBIDITY; MOTHERS; OBSTETRIC LABOR COMPLICATIONS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREMATURE BIRTH; PROSPECTIVE STUDIES; RISK FACTORS; YOUNG ADULT;

EID: 84863865828     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2011.638952     Document Type: Article

References (19)

1. Parry S, Strauss JF 3rd. Premature rupture of the fetal membranes. N Engl J Med 1998;338:663-670. (Pubitemid 28108437)
2. Meis PJ, Ernest JM, Moore ML. Causes of low birth weight births in public and private patients. Am J Obstet Gynecol 1987;156:1165-1168. (Pubitemid 17081437)
3. Aagaard-Tillery KM, Nuthalapaty FS, Ramsey PS, Ramin KD. Preterm premature rupture of membranes: Perspectives surrounding controversies in management. Am J Perinatol 2005;22:287-297. (Pubitemid 41266009)
4. Bek KM, Nielsen FR, Qvist I, Rasmussen PE, Tobiassen M. C-reactive protein (CRP) and pregnancy. An early indicator of chorioamnionitis. A review. Eur J Obstet Gynecol Reprod Biol 1990;35:29-33. (Pubitemid 20064747)
5. Coultrip LL, Lien JM, Gomez R, Kapernick P, Khoury A, Grossman JH. The value of amniotic fluid interleukin-6 determination in patients with preterm labor and intact membranes in the detection of microbial invasion of the amniotic cavity. Am J Obstet Gynecol 1994;171:901-911. (Pubitemid 24341467)
6. Trochez-Martinez RD, Smith P, Lamont RF. Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: A systematic review. BJOG 2007;114:796-801. (Pubitemid 46918717)
7. Romero R, Yoon BH, Mazor M, Gomez R, Gonzalez R, Diamond MP, Baumann P, et al. A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes. Am J Obstet Gynecol 1993;169:839-851. (Pubitemid 23317515)
8. Santhanam U, Avila C, Romero R, Viguet H, Ida N, Sakurai S, Sehgal PB. Cytokines in normal and abnormal parturition: Elevated amniotic fluid interleukin-6 levels in women with premature rupture of membranes associated with intrauterine infection. Cytokine 1991;3:155-163.
9. Buck C, Bundschu J, Gallati H, Bartmann P, Pohlandt F. Interleukin-6: A sensitive parameter for the early diagnosis of neonatal bacterial infection. Pediatrics 1994;93:54-58. (Pubitemid 24012129)
10. Murtha AP, Greig PC, Jimmerson CE, Roitman-Johnson B, Allen J, Herbert WN. Maternal serum interleukin-6 concentrations in patients with preterm premature rupture of membranes and evidence of infection. Am J Obstet Gynecol 1996;175:966-969. (Pubitemid 26357963)
11. Greig PC. The diagnosis of intrauterine infection in women with preterm premature rupture of the membranes (PPROM). Clin Obstet Gynecol 1998;41:849-863. (Pubitemid 29320426)
12. Steinborn A, Günes H, Röddiger S, Halberstadt E. Elevated placental cytokine release, a process associated with preterm labor in the absence of intrauterine infection. Obstet Gynecol 1996;88:534-539. (Pubitemid 26326013)
13. Mitchell MD, Dudley DJ, Edwin SS, Schiller SL. Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells. Eur J Pharmacol 1991;192:189-191.
14. Greig PC, Murtha AP, Jimmerson CJ, Herbert WN, Roitman- Johnson B, Allen J. Maternal serum interleukin-6 during pregnancy and during term and preterm labor. Obstet Gynecol 1997;90:465-469. (Pubitemid 27357943)
15. Murtha AP, Sinclair T, Hauser ER, Swamy GK, Herbert W.N.P, Heine RP. Maternal serum cytokines in preterm premature rupture of membranes Obstet Gynecol. 2007; 109:121-127. (Pubitemid 46043194)
16. Minckwitz GV, Grischke EM, Schwab S, Hettinger S, Loibl S, Aulmann M et al.Predictive value of serum interleukin-6 and 8 in preterm labor or rupture of the membranes. Acta Obstet Gynecol Scand 2000;79:667-672. (Pubitemid 30487552)
17. Pfeiffer KA, Reinsberg J, Rahmun A, Schmolling J, Krebs D et al. Clinical application of maternal serum cytokine determination in premature rupture of membranes-interleukins, an early predictor of infection? Acta Obstet Gynecol Scand 1999;78:774-778. (Pubitemid 29486051)
18. Hatzidaki E, Gourgiotis D, Manoura A, Korakaki E, Bossios A, Galanakis E, Giannakopoulou C. Interleukin-6 in preterm premature rupture of membranes as an indicator of neonatal outcome. Acta Obstet Gynecol Scand 2005;84:632-638. (Pubitemid 40917385)
19. Bahar AM, Ghalib HW, Moosa RA, Zaki ZMS, Thomas C, Nabri OA. Maternal serum IL-6, IL-8, TNF-alpha and IFN - gamma in preterm labor. Acta Obstet Gynecol Scand 2003; 82: 543-549.